1.RUNX1::RUNX1T1 Fusion in Pediatric Acute Myeloid Leukemia: A description of two cases.
Jill Jaime ; Ivy Mae Medalla ; Steffanie Charlyne Tamayo ; Qareem Pido ; Francisco Tria IV ; Ma. Luisa Enriquez ; Jean Kamil Sy ; Reynaldo De Castro Jr. ; Daphne Ang
Philippine Journal of Pathology 2023;8(1):42-48
RUNX1::RUNX1T1 is a core-binding factor driving fusion gene which arises from t(8;21)(q22;q22). It is one of the
most common chromosomal rearrangements in both pediatric and adult Acute Myeloid Leukemia (AML)
with a reported incidence o 15% in children and young adults. There are few case reports documenting
RUNX1::RUNX1T1 translocation in pediatric AML. Although this is generally associated with a favorable
prognosis, we report two (2) cases of de novo pediatric AML in the Philippines harboring a RUNX1::RUNX1T1
translocation, one eventually relapsed while the other attained remission but succumbed to sepsis.
Next Generation Sequencing
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RUNX1::RUNX1T1 fusion
Result Analysis
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