1.Cross - species regulation and underlying mechanisms of parasite - derived non-coding RNAs: a review.
Chinese Journal of Schistosomiasis Control 2023;35(5):529-533
Parasite-derived non-coding RNAs (ncRNAs) not only contribute to life activities of parasites, and microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA) may generate a competitive endogenous RNA (ceRNA) regulatory network with host miRNAs and mRNAs via extracellular vesicles, thereby participating in infection and pathogenic processes. This article presents an overview of characterizing ncRNAs derived from parasites and the cross-species regulatory role of parasite-derived ncRNAs in host gene expression and its underlying mechanisms.
Animals
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Parasites
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Gene Regulatory Networks
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MicroRNAs/metabolism*
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RNA, Messenger/genetics*
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RNA, Circular/genetics*
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RNA, Competitive Endogenous
2.Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis.
Pengfei ZHAO ; Yating WANG ; Xiao YU ; Yabing NAN ; Shi LIU ; Bin LI ; Zhumei CUI ; Zhihua LIU
Frontiers of Medicine 2023;17(5):924-938
Long noncoding RNAs (lncRNAs) play a crucial regulatory role in the development and progression of multiple cancers. However, the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancer remains unclear. In the current study, the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared with primary tumors. Gain- and loss-of-function assays demonstrated that LOC646029 inhibits the proliferation, invasiveness, and metastasis of ovarian cancer cells in vivo and in vitro. Moreover, the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poor prognosis. Mechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related EVH1 domain-containing protein 1, which is necessary for suppressing tumor metastasis and inhibiting KRAS signaling. Collectively, our results demonstrated that LOC646029 is involved in the progression and metastasis of ovarian cancer, which may be a potential prognostic biomarker.
Humans
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Female
;
MicroRNAs/metabolism*
;
RNA, Long Noncoding/metabolism*
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RNA, Competitive Endogenous
;
Cell Line, Tumor
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Ovarian Neoplasms/genetics*
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Cell Proliferation/genetics*
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Gene Expression Regulation, Neoplastic
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Cell Movement/genetics*
;
Adaptor Proteins, Signal Transducing/metabolism*