During the past 100 years, there had been four global pandemics on influenza that had greatly influenced the health and life of the people. This article summarized the features, experiences and lessons learned on these four influenza pandemics so as to prepare related measures targeting the possible pandemics/epidemics in the foreseeable future, in China.
China ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human/epidemiology* ; Pandemics

Every influenza pandemic in history would end up with disastrous outcomes on mankind, of which the most notorious one was the "Spanish flu" pandemic in 1918. In the past century, with advanced knowledge on influenza viruses, laboratory technologies and surveillance methods, human beings were not as helpless when facing the influenza pandemic. In order to control the outbreaks and reducing the negative impacts, programs as: setting up and improving the influenza pandemic preparedness and response plan were recognized as important issues on early detection or prompt warning of any influenza virus strain that might lead to potential pandemics. The scheduled and planned control measures towards the pandemic preparedness and response plan had been considered of key importance in mitigating the peak of pandemic or controlling the transmission of virus. Since the "1918 influenza pandemic" , we had reviewed the evolution and development of plans regarding the preparedness and response on influenza pandemic issued by both WHO and China. We also emphasized on the variety of strategies which were linked to the preparedness and response at different historical stages, to provide reference for the pandemic preparedness of the disease, in the future.
China/epidemiology* ; Disease Outbreaks/prevention & control* ; Forecasting ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human/virology* ; Pandemics/prevention & control*

Acute Lung Injury ; Animals ; Autophagy ; Explosions ; Lung ; Rats ; Rats, Sprague-Dawley