Chronic granulomatous disease (CGD) is a very rare disease whose defect lies in an abnormal intracellular killing resulting in recurrent abscesses, lymphadenitis and granuloma formation. We describe 2 Malay male infants with CGD whom we believe to be the first report of this disorder in Malays. Both children presented with recurrent abscesses, pneumoniae and hepatosplenomegaly; lymphadenopathy was also present in one of the patients. The organisms isolated were catalase positive bacteria. Both neutrophil chemiluminescence (against fungal and bacterial antigens, phorbol myristate acetate) and intracellular killing assays were severely depressed. Recognition of CGD is important as great strides have been made in the treatment of this disease which include gamma interferon therapy besides the conventional prophylactic antibacterial therapy.
Anti-Bacterial Agents ; therapeutic use ; Fatal Outcome ; Granulomatous Disease, Chronic ; diagnosis ; drug therapy ; immunology ; Humans ; Immunity, Cellular ; Infant ; Interferon-gamma ; therapeutic use ; Malaysia ; Male ; Phagocytosis

INTRODUCTION: Online learning was put at the forefront for the safe continuation of education amid the COVID-19 pandemic. This study determined the association of the level of social connectedness and symptoms of burnout in a purely online academic curriculum. METHODS: This analytical cross-sectional study design included medical students enrolled in a private tertiary institution in the National Capital Region as respondents in an online survey. The perceived social connectedness and symptoms of burnout were objectively measured, using previously validated questionnaires, the Social Connectedness Scale - Revised (SCS-R), and the Copenhagen Burnout Inventory (CBI). The prevalence risk ratio (PRR) was computed. RESULTS: Of the 119 respondents, majority reported reduced levels of social connectedness (72.3%) and experienced symptoms of burnout (85.7%). Among those with reduced levels of social connectedness (PRR: 1.25; 1.00, 1.55), there was a higher risk of having symptoms of burnout. CONCLUSION Amid the implementation of a purely online curriculum, medical students with reduced social connectedness had an increased risk of experiencing symptoms of burnout.

BACKGROUND

Nursing, as a profession, is a facet where job satisfaction and performance matter. In the changing landscape of nursing practice in the Philippines and the aftermath of the COVID-19 pandemic, it is imperative to revisit and to perform an empirical investigation of the current state of nurses' job satisfaction and performance in the hospital setting. This study aimed to describe the job satisfaction and performance among staff nurses in private and government hospitals in Baguio City.

DESIGN

Using a quantitative descriptive cross-sectional survey design, a sample of 313 randomly selected staff nurses working in two private and two government hospitals in Baguio City were surveyed from March to April 2023, using a questionnaire. This study's protocol was approved by two ethics committees, namely the Saint Louis University Research Ethics Committee and the BGHMC REC. Nominal data was analyzed using the SPSS trial version employing frequencies, percentages, and the Chi-square test.

FINDINGS

There are more staff nurses in both private and government hospitals who reported satisfactory job satisfaction levels (276 nurses, 87.9%) and had good job performance (303 nurses, 96.5%) in all domains. However, results show that there are more nurses (209 nurses, 90.7% ) in government hospitals who are satisfied with their jobs than in private hospital nurses (67 nurses, 80.1%) in the domains Intra practice Partnership/Collegiality (p=0.010); Challenge/Autonomy (p=0.001); Professional, Social and Community Interaction (p=0.010); Professional Growth (p=0.036); Time (p=0.009); and Benefits (p=0.045). In terms of job performance, more government nurses at 97.3% (224 nurses) rated a higher self-appraisal of job performance. In comparison, only 94.8% (79 nurses) of private staff nurses appraised themselves as having good performance. No significant differences were found in the domains of job performance, namely leadership, teaching, planning, communications, and professional development, except in critical care. In "Critical care," which showed significance, the results suggest that more nurses in government hospitals perceive higher job performance, revealing a significant difference (p=0.011) in the "critical care" domain, indicating that a higher proportion of nurses in government hospitals demonstrate superior performance in this area.

CONCLUSION

Through this study, it was learned that nurses in both private and government hospitals generally experience high job satisfaction and performance, reflecting a fulfilled workforce and indicating commendable competency among the staff nurses. However, more nurses in government hospitals report high satisfaction and perceived performance in critical care compared to those in private hospitals. Thus, the findings of this study can contribute to and serve as a rationale for policy making regarding creating a positive work environment, proper management and leadership, creation of training and skill development for critical care, providing opportunities for professional growth, and conducting regular evaluation and feedback----- all geared towards a satisfied and productive workforce.

Job Satisfaction ; Job Performance ; Work Performance ; Work Environment ; Working Conditions