1.A rat model for cochlear implant research.
Wei LU ; Jin XU ; R K SHEPHERD
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2008;22(13):603-605
OBJECTIVE:
To introduce a rat model for use in cochlear implant related research.
METHOD:
Five deafened Hooded-Wistar rats were implanted with a scala tympani electrode array using a new surgical method. Electrically evoked brainstem responses (EABRs) using bipolar stimulation were recorded and cochlear history was assessed.
RESULT:
Electrically evoked brainstem responses with normal configuration confirmed the functional status of the cochlear implantation. There was no evidence of severe insertion-induced damage of intra-cochlear structure.
CONCLUSION
The surgical method established in the rat model is a safe and effective procedure for acute or chronic cochlear implantation.
Animals
;
Cochlear Implantation
;
methods
;
Cochlear Implants
;
Evoked Potentials, Auditory, Brain Stem
;
Male
;
Models, Animal
;
Rats
;
Rats, Wistar