Objective The aim of this research is to evaluate the influence of nursing intervention on the compliance of patients with dysfunctional uterine bleeding in climacteric period. Methods We divided 96 patients with dysfunctional uterine bleeding in climacteric period from February to December in 2006 into the intervention group and the control group with 48 cases in each group.The control group was given medication instruction simply by the doctors and no nursing intervention.The intervention group was given health education and follow-up supervision.The general information and medical history of patients were registered at the first visit. The medication, adverse effect and effect of drugs were also registered at every visit. All patients were given follow-up visit 3 months later.The medication and visiting compliance and the treatment effect were observed. Results One patients missed follow-up visit in the intervention group and 11 patients missed in the control group.The medication compliance was 87.2% and the visit compliance was 93.6% in the intervention group,which was superior to those of the control group (67.6%,56.8%).The effect of hormone treatment was also better than that of the control group,P ＜ 0.05. Conclusions Nursing intervention couhl improve the compliance and medication effect of patients with dysfunctional uterine bleeding in climacteric period.