1.Pharmacodynamic interaction between propofol and lidocaine during anesthesia induction
Xingan ZHANG ; Ruosong WANG ; Qunling WU
Chinese Journal of Anesthesiology 1994;0(04):-
Objective To study the influence of lidocaine on the propofol concentration effect relationships for loss of eyelash reflex and loss of consciousness,hemodynamic function Methods Thirty eight patients were randomly allocated to receiving a computer controlled infusion of lidocaine at target concentration of 0?g?ml -1 (group A,n=9),1 25?g?ml -1 (group B,n=7), 2 5?g?ml -1 (group C,n=7), 5?g?ml -1 (group D,n=8),or 7?g?ml -1 (group E,n=7) respectively While the target concentration of lidocaine was kept stable, propofol was administrated with a computer controlled infusion at an initial target concentration of 0 5 1?g?ml -1 , which was increased every time by 0 5?g?ml -1 until loss of consciousness Plasma concentrations of lidocaine and propofol were measured with high performance liquid chromatography Results 50% of patients lost eyelash reflex and consciousness at plasma propofol concentrations(Cp50) of 1 78 and 3 17?g?ml -1 in the absence of lidocaine In the presence of plasma lidocaine concentration of 1 25 4 3 ?g?ml -1 ,the Cp50 for loss of eyelash reflex was reduced by 42 1% There was a linear regression relationship between plasma lidocaine concentrations from 0 to 7?g?ml -1 and the Cp50 for loss of consciousness (r=-0 69 ) Conclusions The Chinese Cp50 for loss of eyelash reflex and consciousness are lower than those reported abroad Plasma lidocaine concentration at 4?g?ml -1 can potentiate properly the potency of propofol on the sedation and hypnosis during anesthesia induction
2.Effects of fentanyl and lidocaine on the hypnotic effect of propofol in total intravenous anesthesia
Xingan ZHANG ; Qunling WU ; Huang NIE
Chinese Journal of Anesthesiology 1995;0(10):-
Objective To evaluate the effects of fentanyl and lidocaine on hypnotic effect of propofol in total intravenous anesthesia(TIVA) Methods One hundred and sixty ASAI Ⅲ patients(86 male,74 female) aged (55 0?12 4)yr,weighing (58 0?9 8)kg,scheduled for elective surgery were randomly divided into propofol group(group P,n=30), propofol fentanyl group(group PF,n=52) and propofol lidocaine group (group PL,n=78) Patients with kidney and liver dysfunction, hypertension, neurological and mental disease were excluded All patients were premedicated with intramuscular phenobarbital 0 1g and atropine 0 5mg BP,HR,SpO 2 and BIS were continuously monitored The patients were anesthetized by TIVA with TCI The target plasma concentration for fentanyl was 2?g/L(group PF) and for lidocaine 4mg/L(group PL) The initial target plasma concentration of propofol was set at 1mg/L When pre set concentration was reached, target propofol plasma concentration was increased by increments of 0 5mg/L until loss of consciousness Blood samples were taken before anesthesia(T 0), loss of consciousness(T 1), immediately after intubation(T 2), at skin incision(T 3), 5 and 10 min after skin incision(T 4,T 5), when TIVA was ended (T 6) and when the patient waked up(T 7) for determination of plasma concentrations of propofol, fentanyl and lidocaine Results ED 90 and ED 50 of propofol for loss of consciousness were lower in group PF and PL than those in group P but the difference was of no statistical significance (P
3.Polymorphisms of DNA repair genes XRCC1 and susceptibility to non-Hodgkin lymphoma
Lijuan REN ; Qiaohua ZHANG ; Jingyi SHI ; Qunling ZHANG ; Xiaoxing JIANG ; Shuling HOU ; Yunpeng HUANG ; Weili ZHAO
Journal of Leukemia & Lymphoma 2009;18(4):197-200
Objective To investigate the correlation between XRCC1 R280H,XRCCl TSS+29C/T genetic polymorphisma and susceptibility to non-Hodgkin lymphoma (NHL). Methods The MassARRAY method was applied to detect the DNA repair gene XRCC1 genetic polymorphisms in 73 cases of NHL and 540 cases of normal healthy controls. Chi-square test was performed to calculate the adjusted odds ratios (OR) and 95% confidence intervals (CI). Results For XRCCl R280H genotypes, there was a significant difference between frequencies of the G and A among patients and controls (P=0.001). However, XRCCl TSS+29C/T genotypes had no statistical difference as for the T and C frequencies between patients and controls (P = 0.383). The frequency of XRCCI R280H with at least one A genotype was lower in the NHL cases than in controls, indicating a decreased risk for NHL development (OR=0.309, 95 % CI =0.168-0.567), comparing with GG genotype. In XRCC1 TSS+29C/T genotypes, the frequeney of TC and CC genotype was higher in NHL cases than in controls and associated with an increased risk of NHL development (P=0.472, OR =1.262, 95 % CI =0.669-2.379). Conclusion DNA repair XRCCl gene possesses significant correlation with NHL.
4.A REPORT OF 25 CASES OF TUMORS OF BRAIN STEM
Zhe LIU ; Yonggang ZHAO ; Hongqi CHENG ; Hongwei YAN ; Xie SHI ; Qunling ZHANG
Chinese Journal of Postgraduates of Medicine 2001;24(5):28-29
Objective To evaluate the methods of surgical treatment for tumors of brain stem and their curative effects. Methods: 25 cases of tumors of brain stem were analysed retrospectively. Results: There were 18 cases of astrocytomas, 2 cases of cavernous angioma, 1 cases of hemangioblastoma, 1 cases of dermoid cyst, 1 cases of syringopontia, 1 cases of inflammatory granuloma accompanied with hecrosis and 1 cases of AVM of brain stem in 25 cases. Four patients died after operation. Conclusion: Extrinsic tumors of brain stem could be resected totally or subtotally, resulting in good outcome.
5.A Meta analysis of intra-arterial thrombolysis of recombinant tissue-plasminogen activator for treatment of acute cerebral infarction
Xinggui LI ; Liang CHEN ; Yi KANG ; Ge JIN ; Xin LI ; Rufang ZHANG ; Qunling ZHAN
Chongqing Medicine 2013;(28):3363-3365
Objective To evaluate the efficacy and safety of intra-arterial thrombolysis with recombinant tissue-plasminogen ac-tivator(rt-RA) for treatment of acute cerebral infarction (ACI) .Methods The randomized controlled trials (RCT ) of intra-arterial thrombolysis with rt-PA for treatment of ACI were selected from Cochrane Library ,Medline ,Embase and CBM by the computer re-trieval .A meta analysis of the data were analyzed by using RevMan 5 .1 software .Results A total of 473 patients in 9 selected RCTs were involved in the systematic review .Meta-analysis results disclosed suggested that the effectiveness of intra-arterial thrombolysis treated ACI group was better than that of intravenous thrombolysis group [RR= 1 .26 ,95% CI(1 .09 ,1 .45) ,P=0 .002] .No difference was observed between the two groups in intracranial hemorrhage and mortality rate .Conclusion The current evidence showed that ,the clinical effect of intra-arterial thrombolysis with rt-PA for treatment of ACI was obviously superior to that of intravenous thrombolysis ,but the result still needs to be confirmed by large-sample RCTs .
6.Epidemiological surveillance of Henipavirus in Chongqing
Dan PENG ; Zhilei ZENG ; Dan ZHU ; Xiao CHEN ; Jianping YU ; Mingming XU ; Yingying ZHANG ; Qunling ZHAN ; Hong ZHAI ; Peng XIE
Chinese Journal of Microbiology and Immunology 2008;28(11):1050-1054
Objective To establish nucleic acid testing techniques for detecting Nipah virus (NiV) and Hendra virus (HeV), and to test the NiV and HeV in peripheral blood collected from domestic pigs, cows and goats in Chongqing. Methods Peripheral blood samples of 580 domestic pigs, 250 cows, 180 goats were collected from Chongqing since June 2007 to June 2008. The lymphocytes were separated by density gradient centrifugation and total RNA was extracted using Trizol method for detection of NiV and HeV with one-step real-time RT-PCR. Sequence identification and analysis were performed for positive PCR prod-ucts. Virus isolation and culture were adopted for positive samples, and epidemiologic reports were submit-ted. Results Nucleic acid detections searching for NiV and HeV were successfully performed in animal blood samples collected from Chongqing. "Takeoff points" were not found in fluorescence amplification curves of all samples. Curves kept the same slope, and assays were judged as negative. Conclusion Until now, Neither NiV or HeV infection has been found in domestic animals blood samples collected from Chongqing, which suggest a lower possibility of outbreaks of Nipah disease and Hendra disease in Chongqing in the near future.
7.The detection on the p24 gene fragment of Borna disease virus in brain tissues of animals in Ili, Xin-jiang
Feng HE ; Yuxing FENG ; Houchao SUN ; Zicheng HU ; Hongbo XU ; Mingming XU ; Qunling ZHAN ; Yongbo HU ; Ge JIN ; Yingying ZHANG ; Leilei LI ; Peng XIE
Chinese Journal of Microbiology and Immunology 2010;30(1):31-35
Objective To observe the epidemiology characterization of Borna disease virus (BDV) in animal brain in Ili, Xinjiang, and to find out the potential infection of the Borna disease virus to prevent its outbreak. Methods The BDV p24 gene of animal brain tissues in Ili including 200 horses, 75 donkeys and 100 shepherd dogs was detected by fluorescence quantitative nest reverse transcriptase polymer-ase chain reaction(FQ-nRT-PCR). GFP-p24,pMD-19 plasmid contamination was excluded from positive products. Clone sequencing was used to analyze the homology of gene and amino acid sequence. Results BDV p24 gent was found in 3 Ili horses, 4 Ili donkeys and 9 shepherd dogs, and the positive ratio is 1.5%, 5.3% and 9.0%, respectively. The GFP-p24,pMD-19 were not found in BDV p40 gene and plasmid stand-ard. The sequence of BDV p24 amplification production was totally the same as He/80 virus strain. Conclu-sion Natural infection of BDV may exist in the animals(horses, donkeys and dogs)in Ili, and the epidem-ic strain of BDV in this area was homological as He/80 virus strain.
8.Epidemiological investigation of Borna disease virus infection in horses and donkeys in Yili, Xinjiang
Yiagying ZHANG ; Qunling ZHAN ; Mingming XU ; Jianping YU ; Zhilei ZENG ; Hong ZHA ; Yanxi LIU ; Xiao CHEN ; Dan PENG ; Dan ZHU ; Yongbo HU ; Kang HUO ; Peng XIE
Chinese Journal of Microbiology and Immunology 2009;29(4):321-325
Objective To investigate the epidemiology of BDV infection in Yili horses and Yili donkeys and to analyze phylogenetic source of BDV in Yili area, Xinjiang. Methods We established fluo- rescence quantitative nested RT-PCR to detect BDV p24 segment in peripheral blood mononuclear cells (PBMCs) of 518 Yili horses and 206 Yili donkeys in Yili area, Xinjiang. Positive products were validated by detecting BDV p40 segment and plasmid to preclude the contamination, and were sequenced to analyze the homology of gene sequence, amino acid sequence and phylogenetic tree. Results The positive rates of BDV infection in PBMCs of 518 Yili horses and 206 Yili donkeys were 0.97% and 1.94%, respectively. The results of BDV p40 segment verification were positive in all of the samples of BDV p24 positive. All the samples tested were not contaminated by plasmid. There was a homology of the gene sequence of positive PCR samples with strain He/80. And the gene sequence revealed more than 93% identical to H1766 and strain V. Conclusion Our study suggested BDV natural infection in Yili horses and Yili donkeys. The en- demic BDV had a high degree of identity to strain He/80.
9.Effect of long cotton branch instead of cotton ball in postoperative oral nursing of patients in the department of neurosurgery
Qunling HU ; Jufang ZHANG ; Yuying WENG ; Xiamin QIU
China Modern Doctor 2015;(12):134-136
Objective To investigate the effect of long cotton branch instead of cotton ball in postoperative oral nursing of patients in the department of neurosurgery. Methods All 72 cases of coma from January 2013 to January 2014 were used long cotton branches in postoperative oral nursing (observation group),72 cases of coma from December 2011 to December 2011 were used cotton ball in postoperative oral nursing (control group), the effect of nursing care, oral cavity cleaning degree,nurse fatigue degree score and complication were compared. Results The nursing efficient,oral cavity cleaning degree and nurse fatigue degree score of the observation group was significantly better than the control group(P<0.05);the complication rates of the observation group was significantly lower than the control group(P<0.05). Conclusion Use long cotton branch instead of cotton ball in postoperative oral nursing of patients in the department of neurosurgery,could get more significant clinical effect and lower complication rates.
10. Difference of left ventricular segmental longitudinal strain in patients with lymphoma receiving anthracycline detected by three dimensional speckle tracking imaging
Yuchen XU ; Chujie ZHANG ; Rui ZHAO ; Yiyao HE ; Qunling ZHANG ; Xianhong SHU ; Leilei CHENG
Chinese Journal of Ultrasonography 2018;27(6):467-472
Objective:
To detect the changes of systolic function of left ventricle in patients with lymphoma receiving anthracycline by three dimensional speckle tracking imaging(3D-STI).
Methods:
Thirty patients with newly diagnosed diffused large B-cell lymphoma who had received R-CHOP chemotherapy were enrolled. Left ventricular global longitudinal strain (GLS), global circumferential strain(GCS) and longitudinal strain(LS) on different left ventricular segments were measured by 3D-STI at baseline, after the completion of 2 cycles and 4 cycles of the regimen respectively.
Results:
Compared with baseline, GLS reduced significantly after four cycles of anthracycline chemotherapy(