1. Associations of parental thalassemia with preterm birth and low birth weight
Xiaochun HUANG ; Xiaoqiang QIU ; Xiaoyun ZENG ; Shun LIU ; Fanglian WEI ; Yanning LI ; Tao LIU ; Yanan WU ; Baoying FENG ; Qunjiao JIANG ; Dongping HUANG
Chinese Journal of Epidemiology 2019;40(5):596-600
Objective:
To investigate the association between the preterm birth and low birth weight and parental thalassemia.
Methods:
Pregnant women and their husbands receiving prenatal examination in local hospitals or maternal and child health centers in Jingxi and Debao in Guangxi from January to December 2017 were selected as study subjects. A total of 758 pregnant women with pregnancy outcomes and their husbands, who were both or alone diagnosed with thalassemia through thalassemia gene detection, were selected as case group and 758 pregnant women with pregnancy outcomes and their husbands, who were negative in thalassemia gene detection and hemoglobin electrophoresis test were selected as control groups. The case group were further divided into mother group, father group and both mother and farther group. Clinical and pregnancy outcome data of the study subjects were collected for the analysis on the association between parental thalassaemia and preterm birth or low birth weight by the independent sample