OBJECTIVE: To study the distribution characteristics of paeonol in the plasma and brain tissue of mice.METHODS: The concentrations of paeonol in the plasma and brain tissue of mice were determined by GC-MS and the pharmacokinetic parameters of paeonol calculated with 3P97 software were compared and evaluated.RESULTS: The main pharmacokinetic parameters of paeonol in the plasma and the brain were as follows: Ka:(99.3 h-1 vs 18.22 h-1);t1/2?:(0.04 h vs 0.05 h);t1/2?:(3.95 h vs 71.23 h);t1/2ka:(0.01 h vs 0.04 h);Cmax:(4.57 ?g?mL-1 vs 0.51 ?g?g-1);AUC0→t∶2.32 ?g?mL-1?h,1.62 ?g?g-1?h.CONCLUSION: After intragastric administration,paeonol rapidly absorbed by mice and quickly eliminated from plasma,and it had difficulty in passing through the blood-brain barrier but it has long retention time in brain tissue.

OBJECTIVE:To introduce the practice and experience of clinical pharmacy in our hospital.METHODS:According to the byelaws for assessment clinical pharmacy of three level of first-class hospital,the working contents and experience of clinical pharmacists in our hospital were expounded from aspects of establishing clinical pharmacist system,taking responsibility for drug choice,checking prescriptions,participating in ward rounds and consultation,developing monitoring and reporting on adverse drug reactions (ADR),developing monitoring on clinical rational use of anti-infectives and assisting clinical doctor in monitoring the use of anti-infectives.RESULTS & CONCLUSION:Clinical pharmacists in our hospital have definite goals,and they play a role in clinical rational drug use by participating in clinical treatment.In order to promote rational drug use,clinical pharmacists should strengthen learning to improve their professional qualities,actively participate in clinical treatment,and cooperate well with clinicians and nurses.

Objective To determine the impact of fear of progression on hope level of liver cancer patients. Methods A total of 186 liver cancer patients were recruited from two first-class hospitals in Suzhou by convenience sampling method. They were investigated with fear of progression questionnaire-short form and Herth hope index. The relationship between fear of progression of liver cancer patients and hope level was analyzed. Results The total score of hope level in liver cancer patients was (27.32±5.18) points. There were significant negative correlations between score of fear of progression of liver cancer patients and score of hope level. Regression analysis showed that the factor scores of fear of progression such as physical health and social family could explain 34.8%of the variance for hope level of liver cancer patients after controlling demographic variables. Conclusion Reducing the level of fear progression in patients with liver cancer will help raise the level of hope for patients with liver cancer.

OBJECTIVE:To probe into the characteristics and regularity of adverse drug reactions(ADR)reports in our hospi-tal,and to promote rational use of drug. METHODS:In retrospective study,317 ADR cases reported by clinical departments of our hospital from 2013 to 2014 were analyzed statistically in respects of patient's gender,age,drug type,route of administration, organs or systems involved in ADR,clinical manifestation. RESULTS:Of 317 ADR cases,female who occurred were slightly more than male;the 41-70 year-old patients held the highest peroportion of 53.94%,35.65% were induced by anti-infective drugs, 74.76% induced by intravenous dripping;30.28% manifested as lesion of skin and its appendants. CONCLUSIONS:ADR is asso-ciated with a variety of factors including drug property,individual differences and route of administration,etc. It is important to fo1low indications in drug use and strengthen ADR monitoring to promote rational use of drugs.

Objective: To evaluate the effect of high-fat enteral nutrition on nutritional status and clinical prognosis in acute stroke patients. Methods: 56 cases of acute stroke patients were randomly divided into high-fat enteral nutrition(Supportan) group(high-fat group,28 cases) and standard enteral nutrition(Nutrison Fiber) group(control group,28 cases).All patients were treated by conventional therapy.The levels of blood glucose,hemoglobin,serum albumin,triglyceride,cholesterol,high density lipoprotein and low density lipoprotein,neurologic impairment score(NIHSS),and gastrointestinal side effects were measured before and at the 1st,the l0th,and the 21st day after enteral nutrition.Activity of daily living(ADL) was also observed at the 30th day after enteral nutrition. Results: The nutrition were not different between groups before EN.All nutrition indexes,except of blood glucose,were decreased at the l0th and the 21st day after enteral nutrition in control group.However,in high-fat group only the serum albumin level was decreased and the blood lipid level was maintained normally.The gastrointestinal side effects in two groups were not different.In high-fat group,NIHSS at the 21st day and ADL at the 30th day were markedly improved compared with those in control group(P

Drug Discovery ; Humans ; Multiple Myeloma ; drug therapy

When the central nervous system is stimulated, the opioid neuropeptide?-endorphine (?-EP) is liberated into the blood stream. The result of this work showedthat the antigen-presenting capability (APCP) of normal human monocytes (Mon) wasmarkedly enhanced (P0. 05), sug-gesting that the effect of ?-EP was mediated through the opioid receptors on the Mon.

The Kashin-Beck disease is a kind of unknown cause disabling arthropathy.In recent years,many experts and scholars have done in-depth studies in Kashin-Beck disease.There is a series of research achievements having been made.In this paper we reviewed the latest progress in the condition,etiology and pathogenesis of Kashin-Beck disease.

Objective To evaluate the osteogenic potential of selected exercises and determine which one has the greatest value for the elderly.Methods Twenty healthy old subjects were recruited in the study.Each subject performed the following four exercises in random order:stepping onto a 4-in riser (STEP),sit-to-stand (STS),jumping (JUMP) and marching (MARCH).The subjects performed successively each of the 4 exercises for 1 minute,with an interval of 3 minutes between each.The Vicon action capture system was used to record the peak ground reaction of the subjects during their exercises.The osteogenic index (OI) was calculated by the formula:OI=peak GRF/ (body weight×9.8) × In (number of loading cycles±1).Results JUMP and MARCH had superior OI value (7.52 ±2.06,6.51 ±1.59) than STEP (5.22 ±0.63) among the4 exercises (P＜0.05).STS was found to have the lowest OI (2.23 ± 0.42) in the elderly.There was no significant correlation between the height and OI in JUMP and MARCH (P ＞0.05).Conclusion STEP and MARCH had the higher OI value and could be deemed as the better ways to induce positive effects on bone health in the elderly population.

Objective To investigate the pyschological states and behavior habits of school-age children with cleft of lip and /or palate .Methods 50 children at the age of 8-12 with cleft of lip before the first operation and their parents and 50 normal control children were tested with SAS (social anxiety scale) ,SEC(self esteem scale) ,and CBCL(children behavior checklist) .Results The rate of abnormal tested by CBCL (children behavior checklist)-parent in patients was 22% ,was higher than that in normal 8% (χ2 =3 .85 ,P<0 .05) .The scores of SAS in patients was higher than those in control (t=5 .29 ,P<0 .01) .Conclusion School-age chil-dren with cleft of lip and/or palate had obvious psychological and behavioral problems ,thus ,corresponding nursing and health edu-cation should be applied .