ObjectiveTo approach the effect of early system rehabilitation training on the treatment of old age patients with proximal femoral fracture. Methods110 cases with surgical treatment of 75 years of age or older patients with proximal femoral fractures. according to whether receiving postoperative rehabilitation all the patients were divided into rehabilitation of 55 cases ,55 cases of control group;rehabilitation group were taken to early rehabilitation and training system, the control group received conventional rehabilitation. Clinical curative effect and complication rate of two groups were compared. ResultsAll patients were followed up for 8 months after operation,the rehabilitation group incidence of complications was 16.36 ％, significantly less than the control group, the incidence rate of 34.55％ ( P ＜ 0.05 ) ; functional evaluation of affected limb of rehabilitation group was 89.09 ％ higher than the 63.64％ in control group( P ＜0.05). ConclusionSurgical treatment of elderly hip fracture could decrease complication rate,improve functional evaluation of affected limb and clinical curative effect,could be used properly in clinic.

OBJECTIVE: To study the distribution characteristics of paeonol in the plasma and brain tissue of mice.METHODS: The concentrations of paeonol in the plasma and brain tissue of mice were determined by GC-MS and the pharmacokinetic parameters of paeonol calculated with 3P97 software were compared and evaluated.RESULTS: The main pharmacokinetic parameters of paeonol in the plasma and the brain were as follows: Ka:(99.3 h-1 vs 18.22 h-1);t1/2?:(0.04 h vs 0.05 h);t1/2?:(3.95 h vs 71.23 h);t1/2ka:(0.01 h vs 0.04 h);Cmax:(4.57 ?g?mL-1 vs 0.51 ?g?g-1);AUC0→t∶2.32 ?g?mL-1?h,1.62 ?g?g-1?h.CONCLUSION: After intragastric administration,paeonol rapidly absorbed by mice and quickly eliminated from plasma,and it had difficulty in passing through the blood-brain barrier but it has long retention time in brain tissue.

OBJECTIVE:To introduce the practice and experience of clinical pharmacy in our hospital.METHODS:According to the byelaws for assessment clinical pharmacy of three level of first-class hospital,the working contents and experience of clinical pharmacists in our hospital were expounded from aspects of establishing clinical pharmacist system,taking responsibility for drug choice,checking prescriptions,participating in ward rounds and consultation,developing monitoring and reporting on adverse drug reactions (ADR),developing monitoring on clinical rational use of anti-infectives and assisting clinical doctor in monitoring the use of anti-infectives.RESULTS & CONCLUSION:Clinical pharmacists in our hospital have definite goals,and they play a role in clinical rational drug use by participating in clinical treatment.In order to promote rational drug use,clinical pharmacists should strengthen learning to improve their professional qualities,actively participate in clinical treatment,and cooperate well with clinicians and nurses.

Cornea is an important part of the refractive media.Healthy cornea is clear and avascular.Corneal avascularity is necessary for the preservation of optimal vision and is maintained by a balance between angiogenic and antiangiogenic factors.In a variety of pathologic conditions,the balance between angiogenic and antiangiogenic factors may be tipped towards angiogenic molecules,leading to corneal neovascularization (CNV).Recent research showed that vascular endothelial growth factor (VEGF) is an important factor responsible for CNV.Over the past several years,the safety and efficacy of several new agents targeting VEGF or VEGF receptor (VEGFR) have been verifies in many ocular neovascularization diseases such as age-related macular degeneration, diabetic retinopathy, neovascular glaucoma,retinopathy of prematurity and CNV.These agents not only have revolutionized the therapy of ocular neovascularized disease but also have great potential for other blinding conditions such as CNV.These agents have great potential for the treatment of CNV.This article reviewed the most promising anti-VEGF/VEGFR therapies.

Child ; Hemophilia A ; diagnosis ; therapy ; Humans ; Practice Guidelines as Topic

】 Objective To observe the effects and explore the mechanism of Huaxian Capsule (HXC) on pulmonary fibrosis. Methods 60 rats were divided into the normal group, the HXC group, the prednisone group, and the model group, 15 rats in each group. The pulmonary fibrosis model of rats was established with bleomycin. The experimental rats were sacrificed in batch on the 7th, 14th and 28th day for determining TIMP-1 protein and MMP-2 mRNA expression by immunohistochemistry and in situ hybridization respectively. The outcomes were compared between groups. Results It was showed that TIMP-1 protein and MMP-2 mRNA expression in different stage of pulmonary fibrosis increased significantly and continuously after modeling, showing significant difference in comparison between the model group and the normal group. After HXC treatment, the two indexes expressed weakly as compared with those in the model group, and showed significant difference to those in the model group on 14th and 28th. Conclusion HXC influence on the expression of TIMP-1 and MMP-2 mRNA in rats with pulmonary fibrosis. 【

Objective:To compare the effects between estrogen and Prasterone(Dehydroepiandrosterone,DHEA) on improving atherosclerosis of ovariectomized rabbits. Methods: Thirty female New Zealand white rabbits of three months old were randomly divided into five groups: Group A: normal control;Group B: sham operation + high cholesterol feeding;Group C: ovariectomized + high cholesterol feeding;Group D: ovariectomized + high cholesterol feeding+ estradiol benzoate;Group E: ovariectomized + high cholesterol feeding+ DHEA.Twelve weeks later,all rabbits were sacrificed,the serum TC,TG,LDL-C,HDL-C,NO and estradiol levels were measured.The aortas and uterus were harvested for histomorphometrical evaluation with light and scanning electron microscope.The area ratios of atherosclerotic lesion to endothelium,and the thickness and area ratios of endothelium to the medium were determined by computer. Results: ①Following the treatment for 12 weeks,no significant difference was found in serum TC、LDL-C、HDL-C levels among four groups except in group A.②There were significant differences between the serum triglyceride(TC)levels of group D and group C.③The serum No levels of group D and group E were significantly higher than that of groupC.④The serum estradiol levels of group D and group E were significantly higher than that of groupC.⑤The area ratios of atherosclerotic lesion to endothelium and the thickness and area ratios of endothelium to the medium in group D and group E were significantly lower than that of group C.⑥Endometrial hyperplasia of group D was significant,while there was no such Phenomena in group E. Conclusion: Estrogen and DHEA can alleviate the early pathological changes of atherosclerosis of the ovariectomized rabbits,prevent and reduce the formation of atherosclerosis.

Objective To evaluate and compare the advantages and disadvantages and the clinical applica- _ tion between abdominal hysterectomy (AH) and laparoscopically hysterectomy ( LAH) on the benign lesions of Non-prolapsed Uterus. Methods 400 patients with benign lesions of Non-prolapsed Uterus were divided into two groups. They were AH group (202 cases) and LAH group (198 cases). The effects of clinical treatment of the two groups were compared. Results In LAH group anal exhaust time,postoperative morbidity,length of stay were less than those in AH group,the difference was statistically significant(P <0. 05 ). The cost of LAH group was higher,and all symptoms were relieved after opreation. In LAH group,the average recovery time of the surgery to return to work time was(21 ± 7) d, but in AH group that was( 36 ± 8 ) d. The differences of recovery rime between two groups were statistically significantly ( P < 0.05). In two groups B-myoma were not found obvious by follow-up. Conclusion Different surgical patterns of hysterectomy had their distinctive advantages. The key point of a successful operation was to avoid complications of the operation.

Objective to compare the LMA and intubation in elderly patients with coronary heart disease hemedynamics,respiratory function and the impact of stress hormones.Methods 32 cases of elderly patients with coronary heart disease ASA II level under general anesthesia in the implementation of gastrointestinal surgery,were randomly divided into LMA group and endotracheal intubation group.Before the induction of anesthesia (T0),insert the LMA/endotracbeal tube before(T1),insert the LMA/tracheal tube immediately after(T2),insert the LMA/endotracbeal tube after 5 min(T3) ,10 min(T4),15 min(T5) and the skin incision,(T6) ,immediately after extubation (T7) record SBP,DBP,HR.Application BICORE monitor respiratory function 16 indicators,select T0,T3,T4,T5,T7 record at the suction tidal volume (,VTI),breath tidal volume (VTE),minute ventilation (VE),Inspiratory peak velocity(PIFR),peak expiratory flow rate (PEFR) ,peak inspiratory pressure(PIP) and the average airway resistance (RAWM).Patients in each group T0,T1,T2,T6,T7 at the application of high performance Iiqnid chromatography analysis of plasma epinephrine(AE),norepinephrine(NE),dopamine (DA) level.Results intubation group T2 at the SBP,DBP,HR significantly higher than the LMA group (P＜0.05) ;,VTI,VTE,VE,PIFR,PEFR,PIP and RAWM group there was no significant difference,AE,NE,DA in T2,T7,were significantly higher than the LMA group (P＜0.05).Conclusion Laryngeal Mask Airway general anesthesia for elderly patients with coronary heart disease is better than intubation,easy to maintain stable bemedynamics,the stress response minor,after the restoration of a smooth general anesthesia.