Child ; Hemophilia A ; diagnosis ; therapy ; Humans ; Practice Guidelines as Topic

Objective To determine the impact of fear of progression on hope level of liver cancer patients. Methods A total of 186 liver cancer patients were recruited from two first-class hospitals in Suzhou by convenience sampling method. They were investigated with fear of progression questionnaire-short form and Herth hope index. The relationship between fear of progression of liver cancer patients and hope level was analyzed. Results The total score of hope level in liver cancer patients was (27.32±5.18) points. There were significant negative correlations between score of fear of progression of liver cancer patients and score of hope level. Regression analysis showed that the factor scores of fear of progression such as physical health and social family could explain 34.8%of the variance for hope level of liver cancer patients after controlling demographic variables. Conclusion Reducing the level of fear progression in patients with liver cancer will help raise the level of hope for patients with liver cancer.

】 Objective To observe the effects and explore the mechanism of Huaxian Capsule (HXC) on pulmonary fibrosis. Methods 60 rats were divided into the normal group, the HXC group, the prednisone group, and the model group, 15 rats in each group. The pulmonary fibrosis model of rats was established with bleomycin. The experimental rats were sacrificed in batch on the 7th, 14th and 28th day for determining TIMP-1 protein and MMP-2 mRNA expression by immunohistochemistry and in situ hybridization respectively. The outcomes were compared between groups. Results It was showed that TIMP-1 protein and MMP-2 mRNA expression in different stage of pulmonary fibrosis increased significantly and continuously after modeling, showing significant difference in comparison between the model group and the normal group. After HXC treatment, the two indexes expressed weakly as compared with those in the model group, and showed significant difference to those in the model group on 14th and 28th. Conclusion HXC influence on the expression of TIMP-1 and MMP-2 mRNA in rats with pulmonary fibrosis. 【

OBJECTIVE:To probe into the characteristics and regularity of adverse drug reactions(ADR)reports in our hospi-tal,and to promote rational use of drug. METHODS:In retrospective study,317 ADR cases reported by clinical departments of our hospital from 2013 to 2014 were analyzed statistically in respects of patient's gender,age,drug type,route of administration, organs or systems involved in ADR,clinical manifestation. RESULTS:Of 317 ADR cases,female who occurred were slightly more than male;the 41-70 year-old patients held the highest peroportion of 53.94%,35.65% were induced by anti-infective drugs, 74.76% induced by intravenous dripping;30.28% manifested as lesion of skin and its appendants. CONCLUSIONS:ADR is asso-ciated with a variety of factors including drug property,individual differences and route of administration,etc. It is important to fo1low indications in drug use and strengthen ADR monitoring to promote rational use of drugs.

ObjectiveTo approach the effect of early system rehabilitation training on the treatment of old age patients with proximal femoral fracture. Methods110 cases with surgical treatment of 75 years of age or older patients with proximal femoral fractures. according to whether receiving postoperative rehabilitation all the patients were divided into rehabilitation of 55 cases ,55 cases of control group;rehabilitation group were taken to early rehabilitation and training system, the control group received conventional rehabilitation. Clinical curative effect and complication rate of two groups were compared. ResultsAll patients were followed up for 8 months after operation,the rehabilitation group incidence of complications was 16.36 ％, significantly less than the control group, the incidence rate of 34.55％ ( P ＜ 0.05 ) ; functional evaluation of affected limb of rehabilitation group was 89.09 ％ higher than the 63.64％ in control group( P ＜0.05). ConclusionSurgical treatment of elderly hip fracture could decrease complication rate,improve functional evaluation of affected limb and clinical curative effect,could be used properly in clinic.

Objective:To compare the effects between estrogen and Prasterone(Dehydroepiandrosterone,DHEA) on improving atherosclerosis of ovariectomized rabbits. Methods: Thirty female New Zealand white rabbits of three months old were randomly divided into five groups: Group A: normal control;Group B: sham operation + high cholesterol feeding;Group C: ovariectomized + high cholesterol feeding;Group D: ovariectomized + high cholesterol feeding+ estradiol benzoate;Group E: ovariectomized + high cholesterol feeding+ DHEA.Twelve weeks later,all rabbits were sacrificed,the serum TC,TG,LDL-C,HDL-C,NO and estradiol levels were measured.The aortas and uterus were harvested for histomorphometrical evaluation with light and scanning electron microscope.The area ratios of atherosclerotic lesion to endothelium,and the thickness and area ratios of endothelium to the medium were determined by computer. Results: ①Following the treatment for 12 weeks,no significant difference was found in serum TC、LDL-C、HDL-C levels among four groups except in group A.②There were significant differences between the serum triglyceride(TC)levels of group D and group C.③The serum No levels of group D and group E were significantly higher than that of groupC.④The serum estradiol levels of group D and group E were significantly higher than that of groupC.⑤The area ratios of atherosclerotic lesion to endothelium and the thickness and area ratios of endothelium to the medium in group D and group E were significantly lower than that of group C.⑥Endometrial hyperplasia of group D was significant,while there was no such Phenomena in group E. Conclusion: Estrogen and DHEA can alleviate the early pathological changes of atherosclerosis of the ovariectomized rabbits,prevent and reduce the formation of atherosclerosis.

Esophageal cancer morbidity and mortality are high,but it is also the most difficult to treat and cure one of the malignant tumors.At present,immunoinhibitors have made breakthroughs in the treatment of cancer,and related research,Which have become a hot field for the clinical study of immunological checkpoint procedural death molecule 1 (PD-1) and its ligand PD-L1 antibody.In this paper,we reviewed the progress of PD -1/PD-L1 in esophageal squamous cell carcinoma.

Objective To investigate the relationship between cystatin C (CysC) and severity of the disease and changes of renal function in patients with acute cerebral infarction .Methods A total of 84 patients with acute cerebral infarction (study group) and 84 healthy individuals (control group) were enrolled and serum CysC levels were detected ,and its relationship with the degree of neurological impairment was analysed .500 mL/d (group A) and 375 mL/d (B group) 20% mannitol treatment were used ,and changes of serum CysC levels and renal function before treatment and 5 days and 14 days after treatment were analyzed .Results Serum CysC levels in patients with large ,medium and small infarcts were significantly higher than that in the control group (P<0 .05) .Serum CysC levels in patients with heavy ,medium and mild nerve function defect were significantly higher than that in the control group (P<0 .05) .After treatment ,serum levels of CysC ,creatinine (Cr) and blood urea nitrogen (BUN) in group A and B were increased ,in which serum CysC levels were significantly higher than that before treatment (P<0 .05) .5 and 14 days after treatment ,serum levels of CysC ,Cr and BUN in group A and B were without significant differences(P>0 .05) .Conclusion CysC might be closely related with the severity of acute cerebral infarction ,which could be more useful for monitoring renal function of patients with cerebral infarction than Cr and BUN .

OBJECTIVE: To study the distribution characteristics of paeonol in the plasma and brain tissue of mice.METHODS: The concentrations of paeonol in the plasma and brain tissue of mice were determined by GC-MS and the pharmacokinetic parameters of paeonol calculated with 3P97 software were compared and evaluated.RESULTS: The main pharmacokinetic parameters of paeonol in the plasma and the brain were as follows: Ka:(99.3 h-1 vs 18.22 h-1);t1/2?:(0.04 h vs 0.05 h);t1/2?:(3.95 h vs 71.23 h);t1/2ka:(0.01 h vs 0.04 h);Cmax:(4.57 ?g?mL-1 vs 0.51 ?g?g-1);AUC0→t∶2.32 ?g?mL-1?h,1.62 ?g?g-1?h.CONCLUSION: After intragastric administration,paeonol rapidly absorbed by mice and quickly eliminated from plasma,and it had difficulty in passing through the blood-brain barrier but it has long retention time in brain tissue.