The main objective of this study is to compare the mydriatic effect of tropicamide and epinephrine in rabbits.Preliminary test was done to compare mydriatic effect of balanced salt solution epinephrine and tropicamide.Minimal dose of tropicamide with maximal mydriasis was likewise done using three dilutions.Lastly, comparison of mydriatic effect of tropicamide with epinephrine was done.Preliminary test showed comparable results between tropicamide and epinephrine, with no notable change in size of pupils using BSS.Determination of minimal dose of tropicamide was found to be 0.1 nl of original 0.5% solution diluted with 0.5 ml of BSS, showed maximal mydriasis.Tropicamide showed slower onset of 30 seconds, but onwards until 30 minutes after, it is comparable with sustained mydriasisby epinephrine.This study showed that intracameral tropicamide has comparable mydriatic effect with epinephrine in rabbits.
Animal ; CATARACT ; EPINEPHRINE ; TROPICAMIDE

Purpose: To compare different commercial viscoelastics retained in the anterior chamber in terms of their tendency to cause intraocular pressure (IOP) rise Methods: Twenty-one rabbit eyes (3 per group) were injected with 0.1 mL of viscoelastic materials (VEM). Seven different brands of VEM were tested. IOP was measured for 6 days after injection Results: All eyes exhibited increase from baseline IOP. Peak IOP rise occurred at a median with 4 hours from injection. IOPs returned to normal in all eyes by Day 6. No significant differences in IOP patterns were detected in this small series Conclusion: This study suggests that all of the VEM tested have potential to cause IOP rise and that spontaneous return to normal levels was achieved for all groups after six days. (Author)
Animal ; INTRAOCULAR PRESSURE ; INTRAOCULAR PRESSURE/DRUG EFFECTS