Objective To study clinical effects and adverse reactions of hepatic artery intervention combining targeted therapy on hepatic metastasis of colonic carcinoma. Methods Eighty cases of patients with hepatic metastasis of colonic carcinoma, patients in the control group were selected, patients in the control group were subject to hepatic artery in-tervention therapy according to different methods of treatment , and patients in the observation group were subject to targeted therapy on the basis of that applied to patients in the control group , clinical effects and adverse reactions of patients in two groups were observed. Results The comparison in the total effective rate of patients in two groups (χ2=6.9520,P=0.0084), and the comparison in one-year survival rate of patients in two groups(χ2=4.7760,P=0.0289), the comparison in two-year survival rate of patients in two groups (χ2=5.6144,P=0.0178), the comparison in three-year survival rate of patients in two groups(χ2=4.3988,P=0.0360), and the comparison in five-year survival rate of patients in two groups (χ2=4.4443,P=0.0350), the differences were statistically significant. The comparison in adverse reaction of patients in two groups was not significantly different. Conclusion The hepatic artery intervention combining targeted therapy on hepatic metastasis of colonic carcinoma delivers great effect and significantly prolong the life of patients , being worthy of clinical application.

Objective:To explore the clinical effect of multidisciplinary cooperative intervention in improving self-management and improving fluid retention in the elderly patients with chronic heart failure.Methods:Totally 130 cases of the elderly patients with chronic heart failure from January to December 2018 were enrolled and were divided into control group and observation group with 65 cases randomly. The control group received routine nursing instruction and telephone follow-up. The observation group was given multidisciplinary team guidance to patients self-management in addition to routine nursing instruction and telephone follow-up. After 3 months, the self-management and fluid retention of the two groups were compared.Results:After 3 months of intervention, the scores and total scores of the observation group in the four dimensions of drug management, diet management, psychological and social adaptation management, symptom management were 19.43±0.71,11.51±0.59,19.07±0.65,25.24±1.31, 72.65±7.16, the control group was 11.09±3.40, 6.05±1.71, 12.73±2.49, 15.72±4.18, 46.35±7.83. The scores and total scores of the observation group were better than those of the control group ( t value was 4.835-13.727, all P < 0.05).After intervention for 3 months, the proportion of severe edema, moderate edema and mild edema in the observation group was 4.61% (3/65), 13.85% (9/65), 81.54% (53/65), respectively, and the control group was 38.46% (25/65), 52.31% (34/65) and 9.23% (6/65) respectively. The degree of fluid retention in the observation group was better than that in the control group ( Z value was -2.373, all P < 0.05). Conclusion:Multidisciplinary cooperative intervention can improve self-management and improve fluid retention in elderly patients with chronic heart failure.