Objective:To explore the application effect of self-management intervention in patients with bladder cancer undergoing cutaneous ureterostomy.Methods:A total of 119 patients who received radical total cystectomy and cutaneous ureterostomy in Department of Urinary Surgery of a Class Ⅲ Grade A hospital from January to October 2019 and met the inclusion criteria were selected as the research objects. According to the random number table, they were randomly divided into the control group ( n=60) and in the intervention group ( n=59) . The control group adopted conventional nursing methods, while the intervention group implemented self-management intervention on the basis of the control group. After 6 months of intervention, Adaptation Scale for Stoma Patients and Quality of Life Scale for Stoma Patients were used to compare the adaptation level and quality of life of patients of the two groups. Results:After intervention, the total score of ostomy adaptation level (57.26±10.35) and scores of various dimensions [acceptance (16.43±3.64) , continuous worry (24.18±5.11) and positive attitude towards life (16.65±3.26) ] of patients in the intervention group were higher than those of the control group [ (51.07±10.84) , (15.06±3.73) , (22.02±5.35) , (13.99±3.18) ], and the differences were statistically significant ( t=3.185, 2.027, 2.252, 4.506; P<0.05) . After the intervention, the total score (136.10±35.57) and various scores [physical health (32.41±7.44) , mental health (49.22±14.36) , social health (35.36±9.04) and mental health (19.11±5.98) ] of patients in the intervention group were lower than those of the control group [ (153.09±36.19) , (36.02±7.63) , (54.84±15.29) , (39.15±9.76) and (23.08±5.86) ], and the differences were statistically significant ( t=2.582, 2.613, 2.066, 2.197, 3.658; P<0.05) . Conclusions:Self-management intervention can improve the stoma adaptation level of patients with bladder cancer undergoing cutaneous ureterostomy and improve the quality of life of them, so it is suitable to be applied in the continuous care of patients with stoma.