1.Surgical treatment of refractory slow-transit constipation
Quanhui WANG ; Chunfang GAO ; Dong WEI ; Guang ZHAO
Chinese Journal of General Surgery 1993;0(03):-
Objective To evaluate the method and outcome of surgical treatment for refractory slow-transit constipation (STC). Methods Clinicopathologic data of 24 patients with severe STC which underwent (colectomy) in recent years were retrospectively analyzed. Results 18 of the patients underwent pancolectomy,and 6 underwent subtotal colectomy. All of the 14 STC patients complicated with outlet obstructive (constipation)(OOC) were corrected preoperatively by related surgery. The curative rate of surgical (treatment) was 95.8%,with an average of(3?1.9) times of bowel motion per day. The incidence of (abdominal) distention decreased from 75% to 12.5%. One patient who underwent ileorectal anastomosis (developed) recurrent constipation. Conclusions Colectomy produces satisfactory results in the majority of (patients) with refractory slow-transit constipation.Patients complicated with OOC should undergo energetic (preoperative) correction therapy,in order to ensure a satisfactory surgical outcome.
2.The correlation of brachial ankle pulse wave velocity with arterosclerosis at different estimated levels of glomerular filtration rate
Junxing YU ; Quanhui ZHAO ; Wei LI ; Junjuan LI ; Meng WANG ; Chunhong NING ; Yajing ZHANG ; Shouling WU
Chinese Journal of Internal Medicine 2017;56(9):673-676
To explore the relationship between brachial ankle artery pulse wave velocity of the (baPWV) in different estimation GFR (eGFR) groups and atherosclerosis.In 2010,2012 and 2014,eGFR and baPWV were detected in 1 427 healthy persons.As eGFR level decreased,baPWV increased accordingly with higher proportion of baPWV ≥1 400 cm/s.The percentage of eGFR lower than 60 ml · min-1 · 1.73 m-2 was similar in subgroups with different baPWV.However,the proportion of eGFR reduction ≥ 30% decreased according to the elevation of baPWV.Multivariate logistic regression analysis indicated the lower the eGFR,the higher the risk of atherosclerosis.Low eGFR is an independent risk factor for atherosclerosis.
3. Comparison of arterial stiffness in non-hypertensive and hypertensive population of various age groups
Yajing ZHANG ; Shouling WU ; Huiying LI ; Quanhui ZHAO ; Chunhong NING ; Ruiying ZHANG ; Junxing YU ; Wei LI ; Shuohua CHEN ; Jingsheng GAO
Chinese Journal of Cardiology 2018;46(1):56-63
Objective:
To investigate the impact of blood pressure and age on arterial stiffness in general population.
Methods:
Participants who took part in 2010, 2012 and 2014 Kailuan health examination were included. Data of brachial ankle pulse wave velocity (baPWV) examination were analyzed. According to the WHO criteria of age, participants were divided into 3 age groups: 18-44 years group (
4.Phosphoproteomic investigation of Clostridium acetobutylicum.
Xue BAI ; Jingjing ZHAO ; Qian WANG ; Wei TONG ; Jiyuan ZHANG ; Jin ZI ; Zhen CHEN ; Siqi LIU ; Quanhui WANG
Chinese Journal of Biotechnology 2010;26(10):1357-1362
Protein phosphorylation in bacteria is important for signaling and metabolic activity. Clostridium acetobutyicum can synthesize high yield of organic solvent under acidic condition. How solventogenesis is regulated at molecular level in this bacterium, is not clearly elucidated yet. We used two dimensional electrophoresis (2-DE) and mass spectrometry to have a differential analysis of the bacterial proteins from Clostridium acetobutylicum at acedogenic and solventogenic stage. We focused on these iso-spots with similar molecular mass and different pI values. Totally, eight string spots were identified, which displayed significant changes of pI values as well as spot volumes in response to solventogenic development. The data acquired from mass spectrometry demonstrated that all of the iso-spots contained the phosphrylated peptides. Bioinformatic analysis revealed that these proteins partake in the pathways of solvent synthesis.
Bacterial Proteins
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metabolism
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Clostridium acetobutylicum
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genetics
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metabolism
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Electrophoresis, Gel, Two-Dimensional
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Mass Spectrometry
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Phosphorylation
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Proteome
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analysis
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Proteomics
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methods
5. Impact of change of ideal cardiovascular behavior and related factors on healthy vascular aging
Chenrui ZHU ; Xin DU ; Yan LIU ; Quanhui ZHAO ; Jihong SHI ; Yuntao WU ; Xiaoming WEI ; Huiying LI ; Liming LIN ; Shouling WU ; Zhe HUANG
Chinese Journal of Cardiology 2020;48(1):66-71
Objective:
To investigate the impact of change of ideal cardiovascular behavior and related factors on healthy vascular aging(HVA).
Methods:
This study was a multi-center cross-sectional survey. Six thousand three hundred and sixteen participants who underwent at least 2 healthy examinations from 2006 to 2015 at 11 hospitals, including Kailuan Hospital and so on, and examined brachial-ankle pulse wave velocity (baPWV) during 2010 and 2016, with available information about cardiovascular behavior and factors were included. The cardiovascular health score (CHS) was calculated. Basic CHS was collected from the first examination. The second CHS derived from the healthy examination in the same year of baPWV examination. Change of cardiovascular health score (ΔCHS) was calculated. Participants were defined into 5 groups according to ΔCHS, namely ΔCHS≤-2 (