Objective To investigate the effect of Ketosteril and low protein diet on nutritional status and renal function in patients with chronic kidney disease (CKD). Methods 60 patients with CKD were divided into two groups randomly. The patients were treated with low-protein diet (0.6 g?kg-1?d-1) in control group while the patients was treated with Ketosteril (0.2 g?kg-1?d-1) and low-protein diet (0.6 g?kg-1?d-1) in the test group. The intervention period lasted for 3 months. The body weight, MAC, MAMC and the serum ALB, PA, Tf, BUN and Cr concentrations in the patients were measured. Results Compared with the control group, the body weight, MAC, MAMC were significantly increased in the test group; the serum ALB, PA ,Tf, BUN and Cr concentrations were also improved. Conclusion Combination of Ketosteril and low-protein diet can improve the nutritional status and the kidney function.