Traumatic hematomas in the posterior fossa is relatively rare (only 2.8% in the total cases of hematomas in the cranium), but dangerous because clinical symptoms are not specific and sudden suspension of breathing may lead rapidly to mortality. The author had analysed these cases to find out experiences in the diagnosis and treatment of this disease. The rate of mortality after surgery and medical treatment was 14.3%.
Hematoma ; Diagnosis ; Therapeutics ; Infratentorial Neoplasms

This study was carried out on 36 patients (the youngest was 2 years old and the oldest was 64 years old) with tumors located in the 4th ventricle, which were admitted to Cho Ray Hospital in 2002. Results: meduloblastomas was the most common tumors (58.3%), following ependymomas (19.4%) and astrocytomas (11.1%). Some type of tumors were rare: hemangioblastomas (5.6%), meningioma (2.8%), and lymphoma (2.8%). The median duration of symptoms from the onset to diagnosis was 8 weeks. Most of patients experienced intra-cranial hypertension syndrome (97.2%), and cerebellar syndrome (77.8%). On the brain CT scan images, the different characteristics of tumors including calcifications, hemorrhage, cyst-necrosis, density and contrast enhancements were useful in making differential diagnosis. The rate of lateral and the 3rd ventricular dilatations were very high (94.4%) because tumors quickly blocked flow of cerebrospinal fluid
Fourth Ventricle ; Cerebral Ventricle Neoplasms ; Microscopy, Electron, Scanning ; diagnosis ; neoplasms

Study on 73 fourth ventricle tumors that were operated at Cho Ray hospital, from May 2000 to October 2003. The results: tumors were seen in both children and adults, in male more than female at the ages ranging from 2 years old to 64 years old. The most common age group were 1-10 years (52%), then 11-20 years old (21.9%). In fourth ventricle tumors, the median duration of symptoms prior to radiological diagnosis was 6 weeks. The patients experienced symptoms such as headache, vomitting, vertigo. The common syndromes were: raised intracranial pressure syndrome, cerebellar syndrome, pyramidal syndrome and epilepsy. Brain CT scan, absence of cysts and calcifications, homogeneous hyperdensity favor the diagnosis of medulloblastoma. Ependymomas were typically nonhomogeneous hyperdensity, calcified. Astrocytomas showed nonhomogenous hyperdensity and minimal calcification. Most of cases had ventricular dilatation
Cerebral Ventricle Neoplasms ; diagnosis ; Tomography Scanners, X-Ray Computed

Background: Obstetric complications always are the risk factors which impact on pregnant women, especially no having care and treatment on time. Objectives: (1) To determine the rate of obstetric complications in some communes of Hoai Duc district, Ha Tay province. (2) To identify some factors which may have impact obstetric complications in the community. Subjects and method: Conducting a cross \ufffd?sectional survey with 363 women randomly chosen for sampling from the list of 1.530 women of reproductive age having terminated their pregnancy dressed for a six \ufffd?month period (from 1 October 2004 to 31 March 2005) in 10 communes of Hoai Duc district, Ha Tay province. Results: The obstetric complications rate was 9.9%. Obstetric complications recorded under the research often had the following forms: hemorrhage (94.4%), infection and pre \ufffd?eclampsia/eclampsia, each of them (2.8%). obstetric complications regularly happened with women of over 40 years old (20%). Those complications were closely linked to vaginal bleeding symptom during pregnant period with p<0.05. Conclusion: Obstetric complication rate was 9.9%, mostly hemorrhage. There was close relation between obstetric complication with vaginal bleeding symptom during pregnant period.
Obstetric Labor Complications ; Residence Characteristics ;

Background: Detection of BCR/ABL fusion gene has important significance in diagnosing and monitoring response to therapy in chronic myeloid leukemia. Objective: Application of FISH (Fluorescence In Situ Hybrydization) technique for detection of abl/bcr fusion gene in chronic myelogenous leukemia. Subjects and methods: The study included 10 patients of chronic myelogenous leukemia diagnosed by methods of morphology and cell chemistry. Peripheral blood and bone marrow samples of them were analyzed Philadelphia (Ph1) chromosome by cytogenetic technique. Among them, 5 patients were tested by FISH technique on the slide of interphase and remainders were tested by FISH technique on the slide of metaphase cell. Results: Results of analyzing chromosome of 10 patients showed that 8 patients had Ph1 chromosome. 2 patients without Ph1 chromosome were patients who had not high of leukocyte count: 28x109leukocyte/l and 36x109leukocyte/l, respectively. In the FISH on the slide of interphase, all 5 patients had Ph1 chromosome and abl/bcr fusion gene. In the FISH on the slide of metaphase cell, 3 patients had Ph1 chromosome and abl/bcr fusion gene. Conclusion: FISH technique has been applied successfully to detect ABL/BCR gene in patients with chronic myelogenous leukemia.\r\n', u'\r\n', u'
Leukemia ; Myelogenous ; Chronic ; BCR-ABL Positive/ pathology

Background: In Vietnam, there are a number of studies on the application of ATRA in treating acute promyelocytic leukemia (AML \u2013 M3) but they have still faced with certain difficulties. Objectives: (1). Study PML/RAR alpha fusion gene on the patients diagnosed with AML \u2013 M3. (2). Study the index of hematology of the PML/RAR alpha positive group. Subject and Method: 21 patients with acute promyelocytic leukemia (M3) were studied. All patients were examined with morphology, coagulation and cytogenetic tests and RNA were extracted from leukemic cells and PCR for PML/RAR alpha fusion transcript. Result and conclusion: PML/RAR alpha positive in 67% including 4 patients which were not discovered t(15; 17) by cytogenetic technique. Rates of three subtype (bcr1, bcr2 and bcr3) of PML/RAR alpha were 7 patients (50%), 3 patients (21,5%) and 4 patients (28,5%), respectively. WBC and bone marrow cells of PML/RAR alpha positive group were 5.08+/-3.87 and 155.82+/-106.21. D \u2013 Dimer level was 1954.89+/-1575.28; 93% of patients in the PML/RAR alpha positive group had DIC.
Acute promyelocytic leukemia ; M3 ; PML/RAR alpha

Background: Chromosome mutation type t(8;21) has quite a high frequency in acute myelogenous leukemia, which accounted for about 15% among adult patients. From 2001, the WHO has a new classification for acute myelogenous leukemia based on genetic mutations. Form had AML1/ETO were arranged into genetic mutation group with better prognosis and ability to fully recover after chemotherapy with a high dose of cytarabin. Objective: Study AML1/ETO fusion gene on the patients diagnosed with Acute Myelogenous Leukemia (AML), as well as the clinical features and some haematologic parameters of the AML1/ETO positive group. Subject and methods: 76 patients with AML were treating in the National Institute of Hematology & Blood Transfusion and the Department of Hematology & Blood Transfusion of Bach Mai Hospital from April 2007 to July 2008. These patients were studied for clinical examination, morphology and RNA were extracted from leukemic cells and PCR for AML1/ETO fusion transcript was performed. Results and conclusions: The incidence of AML1/ETO positive in the AML patients was 24%. The incidence of AML1/ETO positive in AML-M2 was 28%. In the AML1/ETO positive group: median age was 26.94+/-9.22; rate of severe anemia, hemorrhage, fever, infection, hepatomegaly, splenomegaly, lymphadenopathy and gum hypertrophy was 44%, 33%, 28%, 11%, 44%, 28%, 17% and 6%, respectively. Median hemoglobin, WBC, platelet, bone marrow cell count, % blast in peripheral blood and in bone marrow was 84.41+/-28.97 g/l, 29.42+/-31.36 g/l, 42.12+/-33.83 g/l, 215.93+/-134.42 g/l, 56.21+/-26.58% and 65.14+/-16.12%, respectively.
acute myelogenous leukemia ; AML1/ETO fusion gene

Ethmoid myoepithelial carcinoma is a rare tumor, with only 14 cases reported to date. This report discusses the largest tumor of this type ever recorded in the ethmoid region. The tumor caused extensive damage to facial structures, complicating treatment. The patient’s age and comorbidities increased the risk of intraoperative bleeding, presenting challenges to the complete removal of the tumor and the reconstruction of the damaged structures. To reduce the risk of intraoperative hemorrhage, shorten the surgery time, and manage potential heartrelated complications, arterial embolization was performed using gelatin sponges and coils. Definitive surgery was then carried out using a skin flap and mucosal flap to successfully reconstruct the defect. Postoperative radiotherapy was deemed unnecessary. The patient recovered well, with a satisfactory aesthetic outcome. No recurrence was observed during a 3-year follow-up period.

Ethmoid myoepithelial carcinoma is a rare tumor, with only 14 cases reported to date. This report discusses the largest tumor of this type ever recorded in the ethmoid region. The tumor caused extensive damage to facial structures, complicating treatment. The patient’s age and comorbidities increased the risk of intraoperative bleeding, presenting challenges to the complete removal of the tumor and the reconstruction of the damaged structures. To reduce the risk of intraoperative hemorrhage, shorten the surgery time, and manage potential heartrelated complications, arterial embolization was performed using gelatin sponges and coils. Definitive surgery was then carried out using a skin flap and mucosal flap to successfully reconstruct the defect. Postoperative radiotherapy was deemed unnecessary. The patient recovered well, with a satisfactory aesthetic outcome. No recurrence was observed during a 3-year follow-up period.

Ethmoid myoepithelial carcinoma is a rare tumor, with only 14 cases reported to date. This report discusses the largest tumor of this type ever recorded in the ethmoid region. The tumor caused extensive damage to facial structures, complicating treatment. The patient’s age and comorbidities increased the risk of intraoperative bleeding, presenting challenges to the complete removal of the tumor and the reconstruction of the damaged structures. To reduce the risk of intraoperative hemorrhage, shorten the surgery time, and manage potential heartrelated complications, arterial embolization was performed using gelatin sponges and coils. Definitive surgery was then carried out using a skin flap and mucosal flap to successfully reconstruct the defect. Postoperative radiotherapy was deemed unnecessary. The patient recovered well, with a satisfactory aesthetic outcome. No recurrence was observed during a 3-year follow-up period.