Objective To investigate the effects of the laparoscopic surgery and open surgery on the postoperative intestinal function recovery time in elderly patients with colorectal cancer(CRC).Methods 66 elderly patients with CRC and treated in the 2nd People's Hospital of Kunming from January 2021to July 2022 were chosen and divided into the control group(n = 33)and the study group(n = 33)according to different operation ways.And the postoperative bowel function recovery time,radical,complications and surgical index were compared between the two groups.Results The recovery time of intestinal function in the study group was significantly shorter than that in the control group(P<0.05),but there was no significant difference in radical indicators between the two groups(P>0.05).The incidence of complications in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).The operation time of the study group was longer than that of the control group and there was the statistically significant difference(P<0.05),while the bleeding was less than that of the control group and there was the statistically significant difference(P<0.05).Conclusion Compared with the open surgery,laparoscopic surgery can more effectively shorten the recovery time of postoperative intestinal function,reduce the incidence of complications and intraoperative blood loss in elderly patients with CRC.Although there is no significant difference between two kinds of operation mode in terms of radical,it should be considered when it is applied in the specific operation time and other factors.

Objective: To elucidate the anti-inflammatory mechanism of Reduning Injection (RDN) by analyzing the potential biomarkers and metabolic pathways of the carrageenan-induced inflammatory model from the overall metabolic level. Methods: Rat inflammatory model was established by carrageenan. UPLC-Q-TOF/MS was used to detect and analyze changes of endogenous metabolites in the serum and urine of carrageenan-induced inflammatory rats. Combined with multivariate analysis and databases analysis, inflammatory-related potential biomarkers were screened and identified to analyze possible metabolic pathways. The reliability and biological significance of these biomarkers was verified by metabolic network analysis and correlation analysis with pharmacodynamic indicators. Results: A total of 16 potential biomarkers were screened and identified by multivariate analysis and metabolite databases, among which 13 species could be adjusted by RDN. The metabolism pathway analysis revealed that histidine metabolism, sphingolipid metabolism, and tyrosine metabolism were greatly disturbed. Their biomarkers involved urocanic acid, sphingosine, and norepinephrine, all of which showed a callback trend after RDN treatment. The three biomarkers had a certain correlation with some known inflammatory-related small molecules (histamine, arachidonic acid, Leukotriene B4, and PGE