Esophagus ; Foreign Bodies ; Humans ; Infant ; Male

Angiogenesis Inhibitors ; therapeutic use ; Endostatins ; therapeutic use ; Histiocytic Sarcoma ; drug therapy ; Humans ; Male ; Middle Aged ; Recombinant Proteins ; therapeutic use

Objective To choose proper proton magnetic resonance spectroscopy(~1XH-MRS) parameters to fit for practical femoral marrow cavity and to produce short-timed,well-repeated and excellent ~1H-MRS images.Methods The tentative study of ~1H-MRS on the normal femoral bone marrow in 26 volunteers was performed with a 1.5 T MR after the informed consent.The single-voxel spectroscopy and stimulated echo acquisition mode were used for ~1H-MRS collection.~1H-MRS parameters for 12 volunteers were 128 acquisitions,1 cm?1 cm?1 cm volume of interest(VOI)size and repeatedly 2—3 times within the same location.~1H-MRS parameters for another:14 volunteers were different numbers of acquisition (128 and 256 times,respectively)and different VOI sizes(2 cm?2 cm?2 cm and 1 cm?1 cm?1 cm, respectively).Results For ~1H-MRS with 1 cm?1 cm?1 cm size of VOI and 128 times of acquisition with the full width haft max of water≤8—12 Hz,the base-line was steady and the signal-noise ratio was high up to 11.31.~1H-MRS was different in the different femoral locations showing the maximum peak sites at near 0.90 ppm(?10~(-6))or 1.65 ppm,but~1H-MRS within the same location was always same or similar with different VOI sizes(1 cm?1 cm?1 cm or 2 cm?2 cm?2 cm)or different numbers of acquisition(128 or 256 times).~1H-MRS acquisition time was not related with the size of VOI but with the numbers of acquisition.128 and 256 times of acquisition cost 199 s and 391 s,respectively.Conclusion With the technique of small size of VOI(1 cm?1 cm?1 cm)and decreased numbers of acquisition(128 times),it is propable to get well-repeated and excellent ~1H-MRS within less time.It is also more practical for clinics to achieve ~1H-MRS of the femoral marrow with the proper technique.

Adolescent ; Apolipoproteins E ; blood ; Humans ; Hyperlipoproteinemias ; complications ; Hypolipidemic Agents ; therapeutic use ; Kidney Diseases ; blood ; drug therapy ; pathology ; Kidney Glomerulus ; blood supply ; pathology ; Male ; Thrombosis ; pathology

Objective To explore the effects and safety of hemoperfusion(HP) therapy on tetramine poisoning in infants.Methods Thirty-five infants with tetramine poisoning were divided into two groups: HP group(n=18) and non HP group(n=17).The changes of blood tetramine concentration and clinical symptom improving of both groups after the treatment were observed together with the adverse effects of HP group.Results The average blood tetramine concentration of HP group was higher than that of non HP group(342.2?333.4 vs 117.9?50.8 ?g/L,P

OBJECTIVETo evaluate the role of adiponectin in regulating tumor necrosis factor alpha (TNF alpha) production and preventing fulminant autoimmunological damage of hepatocytes following concanavalin A (Con A) injection into mice.

METHODSThree days after recombinant plasmids pAA-neo-mAd were injected into the mice via the tail veins, Con A was injected into the mice. Mice transfected with empty pAA-neo vector served as controls. The serum levels of alanine aminotransferase (ALT), TNF alpha and adiponectin were detected, and histological examination of livers was carried out at different time points after the Con A injection. All results were subjected to statistical analyses.

RESULTSHistological examinations showed that the damage in livers of mice with high serum adiponectin levels was milder than that of the controls. The serum levels of ALT and TNF alpha were both lower than those of the controls (P less than 0.01, respectively). Statistical analyses showed the serum levels of ALT was negatively related to the levels of adiponectin in the sera (r=-0.5034).

CONCLUSIONAdiponectin is effective in protecting hepatocytes from Con A-induced immunological injury. The mechanism of this protective effect may be caused by inhibiting the synthesis and/or release of TNF alpha.

Adiponectin ; blood ; pharmacology ; Alanine Transaminase ; blood ; Animals ; Concanavalin A ; adverse effects ; Female ; Immune System Diseases ; chemically induced ; pathology ; prevention & control ; Liver ; drug effects ; pathology ; Liver Diseases ; pathology ; prevention & control ; Mice ; Mice, Inbred BALB C ; Tumor Necrosis Factor-alpha ; blood

Objective To analyze 7 cases of plastic bronchitis in children,review the literature,and improve the understanding of the clinical features,diagnosis and treatment of the disease.Methods Seven children (6 male and 1 female) aged from 2 to 12 years with plastic bronchitis presenting cough,wheezing and dyspnea,who were treated in Nanjing Children's Hospital Afiliated to Nanjing Medical University from Sep.2006 to Mar.2012,were analyzed,respectively.The treatment of the 7 cases included flexible bronchoscopy or rigid bronchoscopy,supplemented by oxygen therapy,antibiotics,and atomizing inhalation.Results All 7 children had acute onset,in which 6 cases presented cough and polypnea,1 case presented emptysis.With the development of the disease,hypoxemia occurred.The chest Xray and Computerized Tomography examination showed pulmonary atelectasis in all 7 cases,while atelectasis and emphysema coexisted in 3 cases,pleural effusion in 3 cases.According to the obstructive site,1 case was in left bronchus and 6 cases in right.One case received rigid bronchoscopy,and 1 case received flexible bronchoscopy after taking rigid bronchoscopy,while 5 cases received flexible bronchoscopy.Five cases were cured after first operation,2 cases had second flexible bronchoscopy,and endogenous bronchial-shaped casts were removed under bronchoscopy.Pathological results showed the casts were classified as 6 cases of type Ⅰ,inflammatory,and 1 case of type Ⅱ,acellular.Four cases improved markedly,and 3 cases were cured.Conclusions Plastic bronchitis in children is a life-threatening disorder.Flexible bronchoscopy or rigid bronchoscopy extraction of branching plastic casts must be performed urgently for early diagnosis and good therapeutic result.

Objective To recognize the clinical characteristics and treatment of bronchiolitis obliterans (BO) in children.Methods Clinical analysis was done on data of 28 patients with BO diagnosed in Nanjing Children's Hospital Affiliated to Nanjing Medical University from Dec.2001 to Aug.2012.Clinical manifestation,etiology,chest X-ray,computed tomography (CT),pulmonary function,flexible bronchoscopy,treatment and prognosis of the children were analyzed.Results Boys were common in all 28 children (20 boys and 8 girls) aged from 4 months to 7 years.All cases presented with persistent cough and wheezing for more than 6 weeks,and crackles as well as wheezing were heard.Twenty-three cases were post-infectious BO (PBO),and 5 cases occurred after Steven-Johnson syndrome(SJS).Pulmonary CT showed mosaic perfusion in all cases,atelectasis in 7 cases,and bronchiectasis in 4 cases.Lung function revealed obstructive ventilatory dysfunction in 16 cases,and mixed ventilatory dysfunction in 3 cases.Thirteen cases received flexible bronchoscopy,and the cell of the bronchoalveolar lavage fluid showed increased level of neutrophils.All the cases received oral corticosteroid,azithromycin and inhalation of corticosteroid and bronchodilator,or oral leukotrienes receptor antagonists.After a follow-up in 23 cases for 5 months to 7 years,there was no death occurred.Besides 7 cases experienced regular treatment were ameliorated in clinical presentation,pulmonary imaging and function,the rests experenced persistent symptoms.Conclusions BO in children mostly follows lower respiratory tract infection and SJS.Diagnosis is made according to clinical productive cough and wheezing,mosaic perfusion in pulmonary CT and airway obstructions in pulmonary function.Corticosteroid is mainly used in treatment of BO,and its overall prognosis is poor.

Adolescent ; Adult ; Carrier State ; pathology ; psychology ; Female ; Hepatitis B ; pathology ; psychology ; Hepatitis B virus ; Humans ; Liver ; pathology ; Male ; Middle Aged ; Young Adult

The discussion centered primarily on background, basis and research ways of the study on producing area suitability of genuine traditional Chinese drugs in this paper. The authors expounded application and development of the used modem techniques. The direction and strategy of producing area suitability of genuine traditional Chinese drugs for the future were proposed and prospected aiming to provide with scientific thoughtway and guiding later production and practice.
Climate ; Drugs, Chinese Herbal ; Ecosystem ; Geographic Information Systems ; Pharmacognosy ; Plants, Medicinal ; genetics ; growth & development ; Random Amplified Polymorphic DNA Technique ; Soil ; Technology, Pharmaceutical ; methods