Objective To evaluate the effect of dexmedetomidine on p38 mitogen -activated protein kinase (p38MAPK)signaling pathways in ventilator -induced lung injury of rats.Methods 100 SD rats were divided into 5 groups(n =20)by random number table.The control group(Group C),mechanical ventilation(Group H)and different dosage of dexmedetomidine group (Group DEX1 -3 ).Group C:no mechanical ventilation with natural breathing air for 4h;Group H:high tidal volume ventilation for 4H,inhaled oxygen concentration was 21%;Group DEX1 -3:20min before mechanical ventilation,infusion of dexmedetomidine(0.5,1.0,and 2.0μg/kg)with loading dose (5mL,0.5,1.0,and 2.0μg·kg -1 ·h -1 )for 4 hours.Femoral arterial blood were collected after mechanical ventilation for 1h,2h and 4h(T1 -4 )in basic status,the arterial blood gas and the PaO2 were analysized and recorded. concentration of total protein,TNF -αand macrophage inflammatory protein -2(MIP -2)in bronchoalveolarlavage fluid(BALF)were detected in rats after ventilation for 4h;myeloperoxidase(MPO)activity in lung tissue was deter-mined;intercellular adhesion molecule -1(ICAM-1)expression and lung wet/dry weight(w/d)ratio were detected;p -p38MAPK protein expression was detected by Western blot;pathological changes of lung tissue in each group and cell apoptosis were observated.Results Compared with the group C,expression of P -p38MAPK(5.4 ±0.5)and p38MAPK/p -p38MAPK(1.64 ±0.17)increased in Group H(F =3.22,3.28,all P <0.05),accompanied by the increased expression of CAM-1 in lung tissue,MPO activity,total protein,TNF -αand MIP -2 concentration in the BALF[(6.4 ±1.1),(1.95 ±0.16)U /g,(1 459.39 ±0.29)mg/L,(182 ±9)ng/L,(436 ±31)ng/L](F =3.53, 3.66,3.21,3.32,3.43,all P <0.05);.And compared with group H,expression of p -p38MAPK and p38MAPK/p -p38MAPK in DEX2 groups and DEX3 fell(F =3.22,3.28,all P <0.05)accompanied by decreased expression of CAM-1 in lung tissue,MPO activity,total protein,TNF -a and MIP -2 concentration in the BALF(F =3.53,3.66, 3.21,3.32,3.43,all P <0.05).Compared with the group H,PaO2 at each point showed no statistically significant difference in group DEX1 -3(F =1.43,P >0.05),and no significant difference of W/D in group DEX 2 ~3(F =2.89,P >0.05 ).Heavy pathological damage of lung tissue and significant apoptosis were observed in group H. Conclusion Dexmedetomidine can inhibit the development of ventilator -associated lung injury.The mechanism may associated with the inhibition of phosphorylation of p38MAPK,thereby inhibiting the expression of downstream inflam-matory factors.

This paper reviewed the main mosquito-species resource of China recorded during 1828-2002 in different periods through Feng(1938),Meng(1955),Lu(1977),to Qu(2002).According to the new systematic series of Reinert(2001),the mosquito-record of China would be totally: 21 genera,52 subgenera,and 395 species/ subspecies up to 2006.The first report of mosquito studies in China including: new species described by foreigner or Chinese entomo-logists,check list,hand-book of "key to Chinese mosquitoes",and "Fauna of China" were cited.And with some discu-ssions on guarantee of the quality of resource materials,its utilization and resource-sharing.

Objective:To study the clinical and pathological features of small cell carcinoma of cervix.(SCCC).Methods:Clinical data,pathological changes and immunohistochimical findings were reviewed in 7 cases of small cell cervical carcinoma(SCCC),and immunohistochemical staining was performed for VEGF in 4 cases of SCCC.Results:The average age was 37 years in 7 patients,and the main symtoms were vaginal bleeding.Under microscope,tumor cells showed oat or intermediate cell type,Three tumors were associated with other forms of carcinoma: squamous cell carcinoma,endometrial carcinoma,poor-differentiated adenocarcinoma.Immunohistochemical staining showed neuroendocrine differentiation and VEGF.Their FIGO staging was stage Ⅰ_b in 2 cases,stage Ⅱ in 2 cases,stage Ⅲ in 2 cases.In the 5 patients with follow-up data,4 were dead and 1 was in following up.Conclusion:Small cell carcinoma of the cervix has stated an extremely aggressive biological behavior with minimal survival chances and a rapid and fatal clinical course.

The present review deals with the representative research papers on human parasites and parasitic diseases in China over the past hundred years (1871-2006). As the views focused on the development of the medical parasitology,the historical background and progressive characters in the period of fermentation,origination,and expansion have been discussed. The check list of the first cases of human parasitic diseases reported in China during 1871-2006 contained 128 species of parasitic pathogens,and among them 38 species were the newly revisional records. The citation from Faust's paper(1923) proved that previous record of "the first case of Eurytrema pancreaticum from Hongkong" was an absurdly mistake. The human infections of Diphyllobothrium latum,Toxocara canis,and Triodontophorus minor discovered by Lin(1924) from Beijing were the first records in the country. A doubtful malaria case reported from Chongqing by Hung(1944) should be revised as the first case of babesiosis in China. The above-presented examples suggest that the truthful record of parasitic pathogens is an important base for the discovery history of parasitic diseases. With comments on the research progress of human parasitic diseases in different historical stages,it seems that the trends of medical parasitology development in China have been synchronous with the research activities in the area.

Objective:To analyze the operation principle and property of medical drying sterilizer. The common faults and repair method for automatic controlling and pneumatic system of drying sterilizer are studied. Methods:Taking Austar drying sterilizer as example, based on the dry-heat sterilization principle, the operating process and using notes are described. Based on the operating experience, normal alarm processing, failure recovery and maintenance methods are given. Results:under proper and systemic maintenance, the Austar drying sterilizer can keep normal operating condition for a long time without any accident. Conclusion:as a kind of familiar sterilization equipment, medical drying sterilizer can hold a good operating state for long time with scheduled maintenance, periodic inspection and timely repair.

Objective To explore the effects of hydroxyurea(HU) combined chemotherapy in treating hyperleukocytosis acute leukemia(HAL).Methods All the 21 patients were divided into two groups randomly.The patients of experiment group were treated by HU,(0.1g tid po),continuing 3-7 days,along with allopurinol(200 mg tid po).The 18 patients of controlled group were treated only by chemotherapy.Results The results showed the majority(57.1%) patients were of completely remiss(CR),the proportions of partly remission(PR) and no remission(NB) were 19.0% and 23.8%.To- tal remission rate was 76.1%.Two patients died early(9.5%.In the controlled group,the rate of CR,PR,NR were 16. 7%,33.3%,and 50%.Four patients died early(22.4%).Conclusion The HU combined chemotherapy had higher re- mission rate than that of chemotherapy in treating HAL.

Objective To explore the drug resistance of Staphylococcus isolates and offer scientific basis for reasonable usage of antibiotics.Methods MIC test was taken by broth microdilution method in 216 strains of Staphylococcus.Methicillin resistant Staphylococcus(MRS)strains were identified by Cefoxitin Kirby-Bauer disk diffusion method.Results The prevalence of methicillin-resistant Staphylococcus aureus(MRSA)and methicillin-resistant coagulase-negative Staphylococci(MRCNS)was 53.7% and 91.9%,respectively.Resistant rates of MRSA and MRCNS were higher than those of methicillin-susceptible Staphylococcus aureus(MSSA) and methicillin-susceptible coagulase-negative Staphylococci(MSCNS) to antimicrobial agents commonly used in clinic.Most of isolates of Staphylococcus were susceptible to synercid.All isolates were susceptible to both vancomycin and linezolid.Conclusion The increase of isolated rates of MRSA and MRCNS and the emerging bacterial resistance warrants further enhancing the detection of MRS and the surveillance of bacterial resistance to inform the rational use of antimicrobial agents and containment of bacterial resistance.

40 cases of primary lung cancer with metastatic pleural effusion were treated by both of bronchial arterial infusion(BAI)of anticancer drugs and intrapleural in- jection of CDDP after drainage.The result of the studies showed as follows:The complete remission(CR)in 10,partial remission(PR)in 12,thus the response rate(CR+PR)was 75%(30/40).This method can prolong survival period,relieve pain,raise life qualities. Therefore a valuable palliative therapy.

Objective To study the characteristics of immunophenotype and bone marrow in chronic lymphocytic leukemia (CLL) in order to provide certain reference for its clinical diagnosis and treatment .Methods A total of 69 cases of CLL in our hos‐pital from January 2013 to January 2015 were selected .The immune 69 cases was analyzed by using the single parameter and multi‐parameter flow cytometry .The bone marrow and blood examinations were performed and the myeloproliferative degree was ana‐lyzed .Results Among 69 cases of CLL ,33 cases (47 .83% ) were LL/SL‐MC ,16 cases (23 .19% ) were CLL/PLL‐MC ,9 cases (13 .04% ) were TSL ,4 cases (5 .80% ) were ATLL ,4 cases (5 .80% ) were PLL and 3 cases (4 .34% ) were HCL .The majority of CLL cases were more than 50 years old .The myeloproliferative degree was hyperactive in 12 cases (17 .39% ) ,significantly active in 10 cases (14 .49% ) and active in 47 cases (68 .12% );the myeloid‐erythroid ratio was increased in 17 cases (24 .64% ) ,normal in 29 cases (42 .03% ) and reduced in 23 cases (33 .33% );the megakaryocyte count was increased in 3 cases (4 .35% ) ,normal in 30 cases (43 .48% ) and reduced in 36 cases (52 .17% ) .All 69 cases expressed CD19 and CD20 with the positive rate of 100% ;sec‐ondly expressed CD22 with the positive rate of 98 .55% ;the CD23 positive rate was 97 .10% ,the CD5 positive rate was 86 .96% ;all cases did not express CD10 .Conclusion The immunophenotype in 69 cases of CLL was mainly the mixed type with higher my‐eloproliferative degree ;the immunophenotype expressed CD19 and CD20 in all cases ,secondly expressed CD22 and CD23 ,and did not express CD10 .

This paper deals with the taxonomic status and specific names of Anopheles anthropophagus and An. lesteri, the important malaria transmitting vector in China. Based on a historical review of the literature recorded from the country, substantial evidence from morphological and molecular biological studies gives reason to convince that An. anthropophagus is a synonym of An. lesteri. A resurrection of the specific name of An. lesteri Baisas et Hu, 1936 brooks no delay.