Objective:To explore the effect of intensive nursing mode on the nursing of colostomy complications of patients with rectal cancer after MILES and its influence on psychological status and quality of life.Methods:62 patients with colostomy after Miles operation were selected as the observation group, and 62 patients with Miles operation after Miles operation between February 2015 and January 2017 were selected as the control group. Comparisons of stoma complications within 3 months after operation were compared between the two groups. Changes of psychological status (fear, depression, anxiety, sensitivity and obsessive-compulsive symptoms), quality of life (physical, cognitive, emotional, role and social function) were compared before and after intervention.Results:The total incidence of complications in the observation group was 11.29% (7/62), which was lower than that in the control group (37.10% (23 / 62). The difference was statistically significant ( χ2 value was 11.261). After 3 months of operation, the scores of phobia, depression, anxiety, sensitivity and obsessive-compulsive symptoms decreased, and the scores of body, cognition, emotion, role and social function increased ( P < 0.05). After 3 months of operation, the scores of phobia, depression, anxiety, sensitivity and the scores of obsessive-compulsive symptoms were (2.51 ± 0.49), (2.33 ± 0.57), (2.33 ± 0.57), (2.07 ± 0.54), (2.66 ± 0.53) and the scores of body, cognition, emotion, role and social function was(16.05 ± 5.45), (13.54 ± 4.13), (14.39 ± 4.26), (15.51 ± 4.73), (16.90 ± 5.03) respectively, which were significantly higher than those of the control group (1.93) ± 0.67), (1.47 ± 0.45), (1.83 ± 0.55), (1.44 ± 0.42), (1.82 ± 0.63), and (9.23 ± 3.25), (8.21 ± 2.44), (9.08 ± 3.13), (6.89 ± 2.25), (7.35 ± 2.17). The difference between the two groups was statistically significant ( t values were 4.263-13.730, P < 0.01). Conclusion:Intensive nursing intervention can significantly reduce the complications of colostomy patients after Miles operation, improve the bad psychological and emotional state, improve the quality of life, and the clinical nursing effect is satisfactory.