1.Application of electrocochleography and ABR in the diagnosis of auditory neuropathy.
Fei JI ; Aiting CHEN ; Yang ZHAO ; Xingjian LIU ; Qiyou ZHOU
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2010;24(10):447-449
OBJECTIVE:
To analyze and compare the clinical application of alternating click evoked electrocochleography (ECochG) and auditory brainstem response (ABR) in the diagnosis of auditory neuropathy (AN) subjects.
METHOD:
ECochGs and ABRs were recorded in 16 patients (32 ears) with AN/AD as AN group and 20 patients (26 ears) with sensorineural hearing loss(SNHL) as control group. Test stimuli were alternating polarity clicks. (1) To compare the occurrence rate of ECochGs and ABRs in AN patients. (2) To compare the peak latency of CAPs, absolute amplitude of CAPs, and amplitude ratios of -SP and CAP between AN group and control group.
RESULT:
ECochGs (--SPs or CAPs) presented in 78.1% (25 among 32 ears) of AN patients. CAPs latency of AN group was shorter than control group (P < 0.05), CAP absolute amplitude of AN group was lower than normal group (P < 0.05), while --SP/CAP was higher than control group (P < 0.01). Deformed ABRs presented in only 5 ears among 32 tested AN ears, while relative good ABR waveforms were evoked in control group. The occurrence rate of ABRs (15.6%) was significantly lower than that of ECochGs in AN patients (P < 0.01).
CONCLUSION
Both ECochGs and ABRs play important role in the diagnosis of AN. The capacity of temporal processing is significantly impaired while the intensity perception related capability is intact in AN patients.
Adolescent
;
Adult
;
Audiometry, Evoked Response
;
Auditory Threshold
;
Case-Control Studies
;
Evoked Potentials, Auditory, Brain Stem
;
Hearing Loss, Central
;
diagnosis
;
physiopathology
;
Hearing Tests
;
Humans
;
Middle Aged
;
Young Adult
2.The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies.
Lei WANG ; Wei WU ; Qi GU ; Zengping LIU ; Qiyou LI ; Zhongwen LI ; Jinhui FANG ; Wenjing LIU ; Jun WU ; Ying ZHANG ; Liu WANG ; Haiwei XU ; Wei LI ; Baoyang HU ; Qi ZHOU ; Zhengqin YIN ; Jie HAO
Protein & Cell 2019;10(6):455-460