0.05), and of metastatic cervical lymphnodes were 88.1 % and 64.3 % respectively (P

Objective:The non targeted high-throughput urine metabolomics technology was used to study the pathogenesis of APP/PS 1 double transgenic mice and the mechanism of action of Gouteng san.Methods:5-month-old APP/PS 1 double transgenic mice were test with Morris water maze for spatial learning ability.Then we employed the non targeted high-throughput urine metabolomics technology to study the pathogenesis of APP/PS1 double transgenic mice based on the metabolic network.The focus investigation of the key pathways and the observation of the treatment by Morris water maze and metabolic level have been used after spatial learning ability damaged confirmed.Results:The comparison between APP/PS1 double transgenic mice and normal mice suggested that a significant longer was existed in former,which was call-back by Gouteng san.With the non targeted high-throughput urine metabolomics analysis and pathway focused analysis,we found certain signals from metabolic profiling,which was identified to be 6 biomarkers associated with learning and memory function by mass spectrometry analysis or authoritative database.Respectively,they were taurine,pteroylglutamic acid,neopterin,glutaurine,2-oxoglutarate and dihydroneopterin.They were mainly related to taurine metabolism and folate metabolism and represented an effective callback.Conclusion:Gouteng san possess a favorable effect on learning and memory ability of APP/PS1 double transgenic mice,6 biomarkers may be a potential target for the pathogenesis of APP/PSI double transgenic mice and provide experimental basis for the study of Gouteng san.

Objective To evaluate the results of operative treatment of comp ou nd acetabular fractures through single ilioinguinal approach. Methods 46 cases o f compound acetabular fractures were treated through single ilioinguinal approac h from June 1994 to October 2003 in our department. Their functional recovery an d complications were followed up. Results On the average, 40 cases were followed up for 40.4 months. All the fractures healed and no infection was found. Clinic al results were excellent and good in 33 patients, and only one patient showed s light ectopic ossification after the operation. Conclusions Acetabular fractures associated with anterior and posterior hemi-transverse fractures, most both co lumn fractures and some T shape fractures can be treated through the single ilio inguinal approach which can result in good reduction, satisfactory functional re covery, less invasive incision, and low rate of postoperative complications.

Objective To compare the efficacy and side effects of intermittent androgen depriva-tion (IAD) versus continuous androgen deprivation (CAD) in prostate cancer. Methods Forty-four patients with prostate cancer were divided into 2 groups. Twenty-one cases (group IAD) received IAD therapy. Of them, TNM staging showed T2 in 7 cases, T3 in 9 cases, T4 in 5 cases. The patients were treated by maximum androgen blockage until the serum PSA decreased to less than 0.2 ng/ml and maintained for 2 months. The treatment was resumed when the serum PSA increased up to 10.0 ng/ml or the symptoms occurred progress. Twenty-three cases (group CAD) underwent CAD therapy. Of them, TNM staging showed T2 in 7 cases,T3 in 12 cases,T4 in 4 cases. The time to prostate cancer progression,quality of life and side effect rate were compared between the 2 groups. Results The median time to disease progression was (36±4) months in group IAD and (30±4) months in group CAD,respectively. There was no significant difference between the 2 groups (P=0.132). The mean cycle length was (15.9±2.3) months, among them time on treatment and time off treatment were(8.8±1.5) months and (7.3±0.8) months, respectively. The symptom scores related to treatment in the treatment period and intermission of IAD group were 55.9±16.8 and 47.9±19.7, respective-ly, there was significant difference between them(P=0.007). But the differences between the treat-ment period and intermission in bone pain,urinary and intestinal symptoms were not significant (P> 0.05). The urinary symptom scores after 5 months of continuing treatment in groug CAD was signifi-cantly higher than the basis reference value which was obtained in the sixth month of initial treatment(P=0. 023), but there was no significant changes in the scores of bone pain, intestinal symptoms and symptoms related to treatment(P>0.05). The incidences of hot flash and gynecomastia were 28.6% (6/21) and 19.0%(4/21) in group IAD, 60.9%(14/23) and 52.2%(12/23) in group CAD, respec-tively. There were significant differences between the 2 groups(P<0.05). Conclusions IAD thera-py can alleviate the side effects of androgen deprivation therapy and improve the life quality. The effica-cy of prolonging the time to androgen independence of IAD therapy is similar to CAD therapy.

Objective To discuss the clinical outcomes of trochanteric digastric osteotomy and surgical hip dislocation for treatment of Pipkin Ⅳ fractures. Methods We retrospectively reviewed the 12 patients with Pipkin Ⅳ fracture who had been treated by trochanteric digastric osteotomy and surgical hip dislocation from February 2012 to June 2016. They were 10 males and 2 females, with an average age of 44. 1 years ( from 24 to 63 years ) . According to the Pipkin classification for femoral head fractures, 9 fractures were type Ⅰand 3 type Ⅱ; according to Letournel-Judet classification for acetabular fractures, 10 were posterior wall fractures ( 9 belonging to the posterior superior subgroup ) and 2 transverse plus posterior wall fractures ( one involving the posterior wall belonging to the posterior superior subgroup ) . The operation time, blood loss, complications and functional results were recorded. Results The operation time averaged 165 min ( from 150 to 195 min ); the blood loss averaged 850 mL ( from 500 to 1, 200 mL ) . A spring plate was used additionally for posterior wall fracture in 7 cases. All the 12 cases obtained an average follow-up of 19 months ( from 6 to 52 months ) . Motion function was fully recovered from 6 weeks to 4 months after operation in 2 cases of preoperative incomplete sciatic nerve injury and in one case of iatrogenic incomplete sciatic nerve injury. Anatomical reduction was achieved in all femoral head fractures. According to the Matta criteria for acetabular fractures, anatomical reduction was achieved in 9 cases, good reduction in 2 and poor reduction in one. Heterotopic ossification occurred in 4 cases ( gradeⅠin one, gradeⅡin 2 and gradeⅢin one by the Brooker grading system ) . The trochanteric osteotomy was repeated in one case. No femoral head avascular necrosis was found. According to the modified Merle d'Aubigné and Postel scoring at the final follow-ups, the functional results of the affected hip were excellent in 4 cases, good in 7 and poor in one. Conclusion Trochanteric digastric osteotomy and surgical hip dislocation is a safe and effective treatment for Pipkin Ⅳ fractures.

Objective To report our preliminary clinical experience of using the Stoppa approach in treatment of pelvic and acetabular fractures. Methods From March 2008 to November 2008, 10 cases of pelvic and acetabular fracture were treated through the Stoppa approach - low abdomen midline or suprapuhic transverse incision and infra-peetineal plating. Of them, 5 pelvic cases were all Tile type C. The Stoppa ap-proach was used to manage each fracture of peripheral pubic ramus. The other 5 cases of acetabular fracture included 2 transverse, 1 posterior column, 1 T type and 1 both column ones. The Stoppa approach was used exclusively in 2 cases, and together with Kocher-Langenbeck or ilioinguinal approach in the other 3 cases. Results The average incision length of the Stoppa approach was 10 cm, the mean operation time and blood loss were 1.5 hours and 560ml respectively. The reduction of the pelvic and acetabular fractures were all excellent. There were no operative complications. Of them, 7 cases were followed up for 4 to 8 months, showing satisfactory functional results. Conclusion The Stoppa approach can replace the ilioinguinal approach in management of fractures of peripheral pubic ramus, and can be used together with other ap-proaches for acetahular fractures, but it has advantages of simple dissection and a low complication rate.

Objective To assess the value of CT or PET-CT with fluorine-18-labeled fluorodeoxyglucose (FDG) for the diagnosis of pulmonary mucosa-associated lymphoid tissue (MALT) type lymphoma. Methods The CT or FDG PET-CT findings in 14 patients with pathologically proved pulmonary MALT lymphoma were retrospectively analyzed. Results Lung lesions were unilateral in 7 patients and bilateral in 7 patients. Lesions presented as a single mass in 3 patients, as a single consolidation in 3 patients, as a nodule in 1 patient, as multiple nodules in 1 patient, as multiple patchy consolidations in 4 patients, as a mass with multiple nodules and patchy consolidations in 1 patients, as diffuse interstitial change in 1 patients. Air bronchogram was found in 9 patients and CT angiogram sign in 5 patients. On PET-CT, lesions showed heterogeneous FDG uptake in 2 patients, maximum standard uptake value was higher than 2. 5. Conclusion Imaging characteristics of pulmonary MALT lymphoma are single or multiple nodules or consolidations with air bronchogram on CT, and heterogeneous high FDG uptake on PET-CT.

To study the diagnosis and treatment of primary testicular neoplasms. Methods:39 cases of primary testicular neoplasms were analysed retrospectively. Results:There were 4,28 and 7 cases in the groups of 1～4 years (10.3％)、15～50 years (71.8％) and over 50 years (17.9％) respectively. 20 patients were semi noma (51.3 ％ ), 18 nonseminoma (46.1％ ), 1 lymphoma (2.6％ ). The cardinal clinical manifestation was painless solid enlargement of the testis. Ultrasonography demonstrated a hypoechoic or heterogeneous echoic mass. CT and MR could provide informations about the retroperitoneal metastasis lymph nodes and malignant changed ab dominal testis. Elevation of AFP and β-HCG noted in 50％ and 40％ of patients with nonseminomatous germ cell tumor? (NSGCT). Combined therapy, including radical orchiectomy、 retroperitoneal lymph node dissection (RPLND) ,radiation therapy and chemotherapy,were taken. 30 patients have been followed up for 2～5 years,2 of them died of distant metastasis. Conclusions: An intratesticular mass must be considered malignant until proved otherwise. Ultrosonography should be included a conventional examination. CT and MR scan is conducive to clinical staging. Tumor marks is helpful to predicting prognosis and monitoring therapeutic response. The choice of treatment is based upon the pathological type and clinical stage.

Objective This single-institution study was to evaluate various diagnostic means for patients with pancreatic cancer. Methods Three hundred and twenty-one patients with pancreatic cancer admitted into our hospital between Jan. 1990 and Dec. 2000 were enrolled, and the clinical data were analyzed retrospectively. Results The most common symptoms of patients with cancer in the head, body and tail and whole pancreas were abdominal pain (55.6%,81.0%,87.5%,respectively) and flatulance (27.8%,39.2%,50.0%,respectively).CA 19-9 was positive in 89.7% of all cases. The positive rate of image examination was 92.0% with MRI, 91.7% with angiography, 84.3% with CT, 80.1% with B ultrasound and 46.7% with GI series. Conclusions Abdominal pain and fullness are the most common symptoms for patients with cancer in the head, body and tail and whole pancreas.CA 19-9 testing presents valuable clues for the diagnosis of pancreatic cancer. All patients aged above 40 who seek medical advice for abdominal pain and flatulance should undergo ultrasound examination and CT scanning.

OBJECTIVETo evaluate prostate specific antigen (PSA) and transition zone index (TZI) as predictors of acute urinary retention (AUR) in men with benign prostate hyperplasia(BPH).

METHODSThe complete data of 602 cases of BPH were reviewed and analyzed.

RESULTSMean serum PSA and TZI were (6.60 +/- 3.4) microgram/L and (0.71 +/- 0.14) in AUR group, (3.51 +/- 2.3) microgram/L and (0.46 +/- 0.21) in non-AUR group, respectively. There were significant differences in serum PSA and TZI between the two groups(P < 0.05). The difference in incidence of AUR between serum PSA < 4.0 micrograms/L, 4.0-10.0 micrograms/L and PSA > 10.0 micrograms/L was significant (P < 0.05). There was significant positive correlation between serum PSA and TZI(r = 0.213, P < 0.01).

CONCLUSIONSerum PSA and TZI were powerful predictors of the risk of AUR in men with BPH.

Acute Disease ; Aged ; Aged, 80 and over ; Humans ; Male ; Middle Aged ; Prostate-Specific Antigen ; blood ; Prostatic Hyperplasia ; complications ; Urinary Retention ; diagnosis