Objective:To evaluate the safety and efficacy of early diet in the patients with mild acute pancreatitis.Methods:Seventy-six patients with mild acute pancreatitis were enrolled.According to the refeeding time,the patients were divided into early diet group (n=3 1)and control group (n=45).Then the recurrent rate of abdominal pain and the levels of pancreatitis re-bound-related indicators after refeeding were observed in the patients of the two groups.Furthermore,the abdominal pain relief rate,Intensive Care Unit (ICU)admission rate,final mortality rate and the average length of hospital stay were compared be-tween the two groups.Results:There was significant difference in refeeding time between the early diet group and the control group (P <0.001).There was no statistical difference in the recurrent rate of abdominal pain after refeeding,the levels of pan-creatitis rebound-related indicators,the relief rate of abdominal pain,ICU admission rate and final mortality rate between the two groups (P >0.05).But the average length of hospital stay in the early diet group was significantly shorter than that in the control group (P <0.05).Conclusions:Early refeeding has no negative effect on the recovery of patients with mild acute pan-creatitis,and it helps to shorten the length of hospital stay.

BACKGROUND: Meshes play a crucial role in hernia repair. However, the displacement of mesh inevitably leads to various associated complications. This process is difficult to be traced by conventional imaging means. The purpose of this study is to create a contrast-enhanced material with high-density property that can be detected by computed tomography (CT). METHODS: The contrast-enhanced monofilament was manufactured from barium sulfate nanoparticles and medical polypropylene (PP/Ba). To characterize the composite, stress tensile tests and scanning electron microscopy (SEM) was performed. Toxicity and biocompatibility of PP/Ba materials was verified by in vitro cellular assays. Meanwhile, the inflammatory response was tested by protein adsorption assay. In addition, an animal model was established to demonstrate the long-term radiographic effect of the composite material in vivo. Subsequent pathological tests confirmed its in vivo compatibility. RESULTS: The SEM revealed that the main component of the monofilament is carbon. In vitro cell experiments demonstrated that novel material does not affect cell activity and proliferation. Protein adsorption assays indicated that the contrast-enhanced material does not cause additional inflammatory responses. In addition, in vivo experiments illustrated that PP/Ba mesh can be detected by CT and has good in vivo compatibility. CONCLUSION These results highlight the excellent biocompatibility of the contrast-enhanced material, which is suitable for human abdominal wall tissue engineering.