Objective To explore the signal transduction of suppressor of cytokine signaling 6(SOCS6)and retinoic acid receptor related orphan nuclear receptor A(RORA)in patients with periodontitis expression of periodontal tissue,and analyze the prognosis of the patients with value.Methods A total of 224 patients with periodontitis who were treated in Jinan Hospital of Traditional Chinese Medicine from July 2021 to Janu-ary 2023 were selected as the study group,and 224 patients who needed to extract healthy teeth due to ortho-dontic treatment to the Jinan Hospital of Traditional Chinese Medicine outpatient were selected as the control group.The periodontal tissues were collected and the expression levels of SOCS6 and RORA in periodontal tissues were detected by real-time fluorescent quantitative PCR.The patients with periodontitis were followed up for 3 months,and according to the follow-up results,they were divided into good prognosis group(148 ca-ses)and poor prognosis group(76 cases).Multivariate Logistic regression analysis was used to analyze the in-fluencing factors of poor prognosis in patients with periodontitis.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of SOCS6 and RORA expression levels in periodontal tissues for poor prognosis in patients with periodontitis.Results Compared with the control group,the expression levels of SOCS6 and RORA in the periodontal tissue of the study group were decreased(P＜0.05).A total of 224 patients with periodontitis were complete follow-up,the incidence of poor prognosis was 33.93％(76/224).The expression levels of SOCS6 and RORA in periodontal tissues of the poor prognosis group were lower than those of the good prognosis group(P＜0.05).Multivariate Logistic regression analysis showed that the af-fected tooth located in the lower jaw,the affected tooth in the anterior teeth,the deepest probing depth of the affected tooth,the severity of periodontitis,the abnormal root morphology,the alveolar bone height,and the average attachment loss were the risk factors for the poor prognosis of patients with periodontitis(P＜0.05).The expression levels of SOCS6 and RORA in periodontal tissues were protective factors(P＜0.05).The area under the curve(AUC)of SOCS6 and RORA alone in predicting poor prognosis of periodontitis patients was 0.833 and 0.829,respectively.The AUC of the combination of SOCS6 and RORA(0.914)was higher than that of SOCS6 and RORA alone(Z=3.659,3.408,P＜0.001).Conclusion The expression levels of SOCS6 and RORA in periodontal tissues of patients with poor prognosis of periodontitis are decreased.Both SOCS6 and RORA have a certain predictive effect on poor prognosis of patients with periodontitis,and the combina-tion of the two has a better predictive effect.