Objective To investigate the present situation of the core competencies of nurses and patient's safety culture cognition in level two class A hospital,and analyze the correlation of the core competence and patient safety culture cognition,so as to offer a proposal to improve the core competence and patient's safety culture cognition.Methods A total of 342 clinical nurses in Hu'nan province from six level two class A hospitals from August to September 2016 by convenient nonprobability sample method,using the general information questionnaire,hospital core competence scale and registered nurses'perception of patient safety culture assessment questionnaire.Results The mean scores of 342 nurses' (from level two class A hospitals) the core competence and the patient's safety culture of nurses' cognition were (2.51±0.69) points and (4.06±0.37) points, which both were at the medium level. The total score of nurses' competency was positively correlated to the total score of patient's safety culture cognition (r=0.395,P<0.01).ConclusionsHospitals should improve construction of medical organization atmosphere,and strengthen the communication and cooperation between higher and lower levels,and promote the team cooperation ability,so as to facilitate the nurses' recognition level for patient's safety culture,reduce adverse event,and provide a better nursing quality.