Objective To investigate the serum of soluble CD40 ligand(sCD40L) in coronary heart disease and its relationship with serum lipid levels and the extent of coronary stenosis,whether upregulation of CD40L system is related to stability of atherosclerotic plaque in patients with acute coronary syndrome.Methods Enzyme-linked immunosorbent assay(ELISA) was used to measure the level of sCD40L in 64 patients with coronary heart disease(18 with acute myocardial infarction,19 with unstable angina pectoris and the other 27 with stable angina pectoris) and 20 matched healthy controls.Coronary stenosis of 29 patients were assessed by angiographic coronary stenosis morphology.Results sCD40L level was significantly higher in patients with acute coronary syndrome(ACS)((19.8?3.0)、(19.6?4.3)ng/mL in acute myocardial infarction and unstable angina pectoris group,respectively)than that of those with stable coronary heart disease and that of controls((8.3?3.2)ng/mL and(2.6?1.9)ng/mL,respectively P

Objective To evaluate the diagnostic value of H-FABP、cTnI and CK-MB for early detection of acute myocardial infarction(AMI).Methods 20 New-Zealand rabbits were randomly divided into 2 groups:surgery group(MI group,n=12) and sham surgery group(control group,n=8).MI group was opened the chests and the anterior descending branches of the left coronary arteries(LAD) were ligated;in sham surgery group the sutures were passed under the LADs without ligation.Blood sampled before surgery and 1,2,3,4,6,8,10 and 24 h after surgery.H-FABP,cTnI and CK-MB were measured by ELISA respectively at the same time.Results The plasma concentrations of H-FABP 1 hour after surgery showed statistical difference between MI group and sham surgery group(P

Objective To explore the optimized ratio of magnesium sulfate and compound polyethylene glycol electric dissolution of two common colon cleansing agent in the preparation of intestinal microscopy, so as to provide references for bowel preparation in clinical colonoscopy treatment. Methods A total of 480 cases of outpatients and inpatients for colonoscopy from March 2016 to March 2017 were selected. All the patients who took magnesium sulfate and compound polyethylene glycol electric dissolution were respectively assigned into four groups according to the dosage and different time of administration, with 60 cases in each group. The effects of bowel preparation and the incidence of adverse effects were compared. Results In the magnesium sulfate groups, there were 53 cases of ClassⅠthe score of bowel cleaning in the group of taking 25% magnesium sulfate 100 ml and water 2 000 ml orally in 1 hour, which was better than the other 3 groups. Hintergroup was 105.654 1 (P<0.01), and Hinterclass was 124.259 9 (P<0.01), and the differences was statistically significant. In the compound polyethylene glycol electric dissolution groups, there were 51 cases of ClassⅠthe score of bowel cleaning in the group of taking 2 boxes of compound polyethylene glycol electric dissolution with water 1 500 ml in 0.5 hour, which was better than the other 3 groups. Hintergrop was 79.280 3, and Hinterclass was 145.504 2, and the difference was statistically significant (P<0.01). There was no statistical significance in the differences of the incidence of adverse effects (H=47.25, 19.50;P>0.05). Conclusions When using magnesium sulfate in the colonoscopy bowel preparation, taking 25% magnesium sulfate 100 ml and warm water 2 000 ml in 1 hour by oral could get the best colon cleaning effects. When using compound polyethylene glycol electric dissolution, the best cleaning effect ratio is 2 boxes of compound polyethylene glycol electric dissolution with water 1 500 ml in 1 hour, which is suitable for popularization and application.