To expound evidence and methodology of relating Chinese materia medica to brain and channel tropism.Evidences of traditional Chinese medical are: correlative medicine,visceral system and channel system recorded in literature.Modern medicine study has found the meridian distribution theory has close relation with blood brain barrier,effective constituents' distribution in the body,receptor theory,cylic nucleotides,and brain protection and so on.It provids reference for future research of relating Chinese Medicine to brain and channel tropism.