Objective To investigate the effect of type 2 diabetes patients with peripheral neuropathy treated with herbs feet bathing therapy combined with foot care.Methods A total of 120 cases with diabetic peripheral neuropathy were selected in our hospital and were randomly divided into control group and combined group, combined group treated with Methylcobalamin dispersible tablets, herbs feet bathing therapy and foot care and the control group was given Methylcobalamin dispersible tablets and warm water feet bathing.Sural nerve and common peroneal nerve conduction velocities before and after treatment and treatment effects were compared between two groups.Results The sural nerve and common peroneal nerve conduction velocities of two groups after treatment were faster than treatment before (P<0.05);The sural nerve and common peroneal nerve conduction velocity of combined group was faster than that of the control group (P<0.05), and the treatment effect of combined group was better than that ofcontrol group (P<0.05).Conclusion Treatment of herbs feet bathing therapy combined with foot care can improve the peripheral neuropathy and curative efficacy in patients with DNP.

Objective To investigate the effect of type 2 diabetes patients with peripheral neuropathy treated with herbs feet bathing therapy combined with foot care.Methods A total of 120 cases with diabetic peripheral neuropathy were selected in our hospital and were randomly divided into control group and combined group, combined group treated with Methylcobalamin dispersible tablets, herbs feet bathing therapy and foot care and the control group was given Methylcobalamin dispersible tablets and warm water feet bathing.Sural nerve and common peroneal nerve conduction velocities before and after treatment and treatment effects were compared between two groups.Results The sural nerve and common peroneal nerve conduction velocities of two groups after treatment were faster than treatment before (P<0.05);The sural nerve and common peroneal nerve conduction velocity of combined group was faster than that of the control group (P<0.05), and the treatment effect of combined group was better than that ofcontrol group (P<0.05).Conclusion Treatment of herbs feet bathing therapy combined with foot care can improve the peripheral neuropathy and curative efficacy in patients with DNP.

The modified early warning score (MEWS), as a rapid assessment and early warning scoring tool, has been widely used in patients in China, which can help nurses to identify potentially critical patients early, but not in all clinical fields. Through the retrieval of the relevant literature of the clinical application of the MEWS in Wanfang Medical Database from 2011 to 2018, the SWOT analysis was used in this paper [strength (S), weakness (W), opportunities (O) and threats (T)] methods, to systematically analyze the advantages, problems existence, implementation opportunities and challenges in the clinical application of the MEWS in our country. The purpose of this study was to obtain the best cut-off value of MEWS in different diseases and to formulate standard early-warning intervention measures for MEWS, which may provide reference for clinical workers to carry out relevant research.

Objective To explore the methods and effects of cultivating altruistic behavior of nursing students. Methods Using convenience sampling method,a total of 189 nursing students from a higher vocational and technical college internship at Pingdingshan the Second People's Hospital from June 2018 to March 2019 were selected as research objects. According to the serial number of practice,the selected students were randomly divided into the study group(n=95)and the control group(n=94). The control group rotated the department after 1 week of routine internship training. One week after the routine internship training,the study group increased altruistic behavior training and volunteer service for a total of three weeks,including:special lectures on humanistic care,sharing of narrative nursing cases,organization of participation in voluntary activities,emergency processing techniques,presentation of model reports around,and so on. Altruistic behavior was evaluated,and the result was one of the conditions for the selection of excellent interns. After the internship,the altruistic behavior of the two groups of interns was investigated,and the scores of each item and each dimension of altruistic behavior of the two groups were compared. Results In the two groups of nursing students' altruistic behavior,there were significant differences in the three dimensions,such as attitude, behavior and quality,scores of each item and total scores(P<0.01). Conclusions Hospital nursing managers should actively train nursing students in altruistic behavior,so as to promote the formation of altruistic behavior of nursing students and facilitate the development of nursing students' career.

The global COVID-19 coronavirus pandemic has infected over 109 million people, leading to over 2 million deaths up to date and still lacking of effective drugs for patient treatment. Here, we screened about 1.8 million small molecules against the main protease (M^pro) and papain like protease (PL^pro), two major proteases in severe acute respiratory syndrome-coronavirus 2 genome, and identified 1851M^pro inhibitors and 205 PL^pro inhibitors with low nmol/l activity of the best hits. Among these inhibitors, eight small molecules showed dual inhibition effects on both M^pro and PL^pro, exhibiting potential as better candidates for COVID-19 treatment. The best inhibitors of each protease were tested in antiviral assay, with over 40% of M^pro inhibitors and over 20% of PL^pro inhibitors showing high potency in viral inhibition with low cytotoxicity. The X-ray crystal structure of SARS-CoV-2 M^pro in complex with its potent inhibitor 4a was determined at 1.8 Å resolution. Together with docking assays, our results provide a comprehensive resource for future research on anti-SARS-CoV-2 drug development.
Humans ; Antiviral Agents/chemistry* ; COVID-19 ; COVID-19 Drug Treatment ; High-Throughput Screening Assays ; Molecular Docking Simulation ; Protease Inhibitors/chemistry* ; SARS-CoV-2/enzymology* ; Viral Nonstructural Proteins