β2-Microglobulin is a small molecule protein, consisting of a polypeptide chain.Previous studies have confirmed that serum β2-microglobulin is a biomarker that reflects early renal function injury, and renal function injury is closely correlated with ischemic stroke.Studies in recent years have shown that the level of serum β2-microglobulin increases significantly in patients with ischemic stroke.Thus, it can be used as a biomarker for the risk of ischemic stroke.

Objective To investigate whether the decision-making ability was impaired under the condition of clear risk probability in patients with cerebral miceobleeds (CMBs).Methods The Game of Dice Test (GDT) with the clear risk probability was used to conduct the risk decision ability study in 45 patients with CMBs and 45 without CMBs.Results GDT showed that patients in the CMBs group was more like to choose the risky option compared with the non-CMB group (9.64 ± 3.22 vs.6.51 ± 4.48;t =3.809,P ＜0.001).Among the 4 options,the most frequent choice in the CMBs group was the option of the highest risk,i.e.2 numbers (6.91 ±3.02 vs.4.71 ±2.95;t =3.494,P =0.001);and the most frequent choice in the non-CMBs was 3 numbers (4.87 ±2.17 vs.7.71 ±2.71;t =-5.496,P＜0.001).The GDT was divided into 3 stages.The number of security options selected by patients in the CMBs group was significantly less than that by patients in the non-CMBs group in all stages (stage 1:-0.27 ± 3.00 vs.0.93 ±3.09;t =-1.867,P =0.065;stage 2:-0.62 ± 2.55 vs.2.27 ± 2.65;t =-5.268,P ＜ 0.001;stage 3:-0.53 ± 2.57 vs.2.89 ± 3.12;t =-5.677,P＜ 0.001),and with the increase of the number of tests,selecting security options increased gradually in the non-CMB group (F =4.780,P =0.010),while the CMBs group was not (F =0.209,P =0.812).Conclusions The patients with CMBs have significant impairment in decision making ability under the condition of specific risk probability.

In recent years, the concept of " microbiome-gut-brain axis" has been proposed to reveal the wide connection between gut microbiome and nervous system diseases. As a common and frequently occurring disease of nervous system, the occurrence and outcome of ischemic stroke are closely related to gut microbiome. This article reviews the relationship between gut microbiome and risk factors of ischemic stroke and immune inflammation after stroke.

Objective:The present study was designed to strengthen the education of research integrity, and to improve the awareness of academic misconduct and academic literacy of medical post-graduate students.Methods:A questionnaire survey was conducted with master post-graduate students of a university affiliated hospital, and statistical analysis on the education of research integrity and the perception of academic misconduct among the survey respondents was performed.Results:Academic master post-graduate students′ cognitions of the misconduct in scientific research process and overall academic misconduct were better than that of professional master post-graduate students, and there were significant differences ( P<0.05). The more times of participation in research integrity training, the better cognition of misconduct of scientific research process, research results publication process, and overall academic misconduct, with significant differences ( P<0.05). Conclusions:The education on scientific research integrity of medical post-graduates should be carried out systematically, while the content should be improved and the form should be enriched for scientific research integrity education, so that the medical post-graduates can have a deeper understanding of the code of academic practices, and an education model of scientific research integrity for medical post-graduate which is suitable for China′s national conditions can be gradually developed.

Objective:To analyze the research hotspots and frontiers of hospital research management research from 1981 to 2022.Methods:The relevant literature in the field of hospital scientific research management was retrieved from the CNKI database to explore the trends of publications in this research field. A scientific knowledge graph was drawn and a visualization analysis of the information of authors, issuing units, and research institutions were conducted by Cite Space.5.8.R3.Research hotspots were discussed based on keyword emergence, cluster analysis, and keyword time zone graph.Results:The publication trend in this field was generally policy-oriented, but the cooperation among authors and institutions was relatively loose, and the research hotspots were gradually shifting from scientific research funding management to discipline construction, talent training, translational medicine, and informatization. Cluster analysis found that the main content of hospital scientific research management was scientific research funding and clinical scientific research management and the main management objects were the medical and nursing staff.Conclusions:Hospital scientific research managers must adhere to the policy-oriented approach, strengthen the cooperation and exchanges in scientific research management, innovate the scientific research management mode around the research hotspots and development trends, and promote the quality and efficiency of scientific research management.

Objective:By analyzing the biomedical papers retracted due to the reason that " original data not provided" , to discuss the necessity of preventing scientific data misconduct and the feasible solutions for its management.Methods:Data of the international papers that were published from Jan 2011 to Dec 2021 and retracted due to " original data not provided" were retrieved from Retraction Watch Database. The data of time distribution, institution, journal sources, reasons for retraction, and disciplinary distribution were statistically analyzed and visually processed by using software packages of Excel, Python 3.7, Gephi 0.92.Results:A total number of 529 papers published in the biomedical field were retracted due to " original data not provided" , and the time of publication and retraction occurred mainly in 2019 (27.41%) and 2021 (41.97%). In addition to the reason " original data not provided" used as search term, the reasons for withdrawal were mainly data and image problems caused by scientific data misconduct, and reasons related to the discovery and investigation process of the paper, and these reasons had a strong co-linear relationship. Besides, the 4 disciplinary of biology-cellular, biology-cancer, genetics, medicine-oncology also had a strong co-linear relationship.Conclusions:It is necessary to incorporating scientific research data management into the scientific research code of conduct, strengthen the training on the code of conduct for original scientific research records keeping, establish the scientific research data review mechanism, and promote the prevention and governance of scientific research data misconduct in the biomedical field.

Objective To study the effect of high rosuvastatin dose on outcome in patients with large artery atherosclerotic stroke (LAAS).Methods Eighty-two LAAS patients were randomly divided into high rosuvastatin dose group (n=39) and routine rosuvastatin dose group (n=43).Their serum blood lipid level and inflammatory indexes were measured and their clinical outcome was assessed.Results No significant difference was found in mortality,recurrence and hemorrhagic transformation between the two groups (P＞0.05).The rate of improved outcome was significantly higher in high rosuvastatin dose group than in routine rosuvastatin dose group (84.62％ vs 65.12％,P=0.04).The serum hs-CRP level was significantly lower in routine rosuvastatin dose group and high rosuvastatin dose group after treatment than before treatment (0.56±0.60 mg/L vs 0.70±0.68 mg/L,P=0.01;0.22±0.29 mg/L vs 0.69±0.58mg/L,P=0.00) and in high rosuvastatin dose group than in routine rosuvastatin dose group after treatment than before treatment (0.22±0.29 mg/L vs 0.56±0.60 mg/L,P=0.00).The rate of LDL C＜1.8 mmol/L and non HDL-C＜2.6 mmol/L was significantly higher in high rosuvastatin dose group than in rosuvastatin dose group after treatment (69.23％ vs 46.51％,P=0.04;66.67％ vs 41.86％,P=0.03).No significant adverse reactions occurred in both groups.Conclusion High rosuvastatin dose can effectively increase the blood lipid level,reduce the serum hs-CRP level,and improve the clinical outcome in LAAS patients.

Objectives:To develop a machine learning prediction model for poor outcome of acute minor ischemic stroke (AMIS) at 90 days after onset and to explain the importance of various risk factors.Methods:Patients with AMIS admitted to the Second People's Hospital of Hefei from June 2022 to December 2023 were included retrospectively. AMIS was defined as the National Institutes of Health Stroke Scale (NIHSS) score ≤5 at admission. According to the modified Rankin Scale score at 90 days after onset, the patients were divided into a good outcome group (<2) and a poor outcome group (≥2). Recursive feature elimination (RFE) method was used to screen characteristic variables of poor outcome. Based on logistic regression (LR), supported vector machine (SVM), and extreme Gradient Boosting (XGBoost) machine learning algorithms, prediction models for poor outcome of AMIS were developed, and the predictive performance of the models was compared by the area under the curve (AUC) of receiver operating characteristic (ROC) curve and the calibration curve. Shapley Additive exPlanations (SHAP) algorithm was used to explain the role of characteristic variables in the optimal prediction model. Results:A total of 225 patients with AMIS were included, of which 152 (67.56%) had good outcome and 73 (32.44%) had poor outcome. Multivariate analysis showed that baseline NIHSS score, baseline systolic blood pressure, hypertension, diabetes, low-density lipoprotein cholesterol, homocysteine, body mass index, D-dimer, and age were the characteristic variables associated with poor outcome in patients with AMIS. The ROC curve analysis shows that the LR model had the best predictive performance (AUC=0.888, 95% confidence interval [ CI] 0.807-0.970), the next was the XGBoost model (AUC=0.888, 95% CI 0.796-0.980), while the SVM model had the lowest performance (AUC=0.849, 95% CI 0.754-0.944). The calibration curve showed that the LR model performed the best in terms of calibration accuracy. SHAP showed that baseline systolic blood pressure, baseline NIHSS score, diabetes, hypertension and body mass index were the top five risk factors for poor outcome of patients with AMIS. Conclusions:The LR algorithm has stable and superior performance in predicting poor outcome of patients with AMIS. Baseline systolic blood pressure, baseline NIHSS score, diabetes, hypertension and body mass index are the important risk factors for poor outcome of patients with AMIS.

Objective To compare the safety,effectiveness and affordability of robotic-assisted thoracic surgery and video-assisted thoracic surgery in the treatment of malignant pulmonary tumors,and provide ref-erences for the management of selection of different surgical strategies for malignant pulmonary tumors in hospitals and medical insurance departments.Methods The medical records homepages and information sys-tem data of patients with malignant pulmonary tumors who underwent major thoracic surgery in this hospital and discharged from January 1 to December 31,2022 were obtained.The patients were divided into the robotic-assistedthoracic surgery group and video-assisted thoracic surgery group according to the surgical methodolo-gies.After performing propensity score matching (PSM),no statistically significant difference was observed in baseline data between the two groups (117 cases in each group).Then the indicators of safety,effectiveness and affordability were compared between the two groups.Results Concerning the safety,the postoperative in-cision infection rate in the robotic-assisted thoracic surgery group was significantly lower than that in the vide-o-assisted thoracic surgery group (P<0.05),and the amount of intraoperative blood loss and postoperative complication rate were not significantly different between the two groups (P>0.05).Regarding the effective-ness,the average surgical duration in the robotic-assisted thoracic surgery group was appreciably shorter than that in the video-assisted thoracic surgery group (P<0.05),no patient in the two groups was converted to open thoracotomy,and there was no statistically significant difference in the average length of hospital stay and postoperative hospital stay between the two groups (P>0.05).With regard to the affordability,the aver-age inpatient expenditure per case and average daily inpatient expenditure per case in the robotic-assisted tho-racic surgery group were significantly higher than those in the video-assisted thoracic surgery group (P<0.05),and there were disparities in the cost structure between the two procedures.The medical cost,adminis-tration cost and consumables cost in the robotic-assisted thoracic surgery group were significantly higher than those in the video-assisted thoracic surgery group (P<0.05).The cost of medical technology in the robotic-assisted thoracic surgery group was significantly lower than that in the video-assisted thoracic surgery group (P<0.05).Conclusion Physicians should comprehensively consider the clinical efficacy and cost burden of patients when selecting the robotic-assisted thoracic surgery or the video-assisted thoracic surgery,and the monitoring and evaluation of the utilization of clinical robotic-assisted thoracic surgery should be strength-ened.

Recent studies have shown that there is a mutual influence between gut microbiota and stroke. Stroke-associated pneumonia (SAP) is a common complication of stroke, which is closely associated with death and poor prognosis of patients. Gut microbiota translocation may be the source of infection of SAP, but the specific mechanism of gut microbiota and SAP remains unclear. This article reviews the relationship between gut microbiota and SAP in order to provide reference for the prevention and treatment of SAP.