Objective:To explore the effect of case-based learning (CBL) based on WeChat platform in orthopedics practice teaching.Methods:A total of 101 orthopedic interns in The First Affiliated Hospital of Navy Medical University Hongkou Campus were randomly divided into two groups, with 50 interns in experimental group and 51 interns in control group. The experimental group conducted CBL based on WeChat platform for teaching, and the control group adopted traditional teaching method for teaching. At the end of the internship, the teaching effect on the interns was assessed by the "department graduation examination" and "questionnaire survey". The examination included basic theoretical knowledge and case analysis. Questionnaire survey included active preparation before class, teaching methods, class participation and discussion, interest in class and teaching effect. SPSS 17.0 was used for statistical analysis.Results:The total scores of the examinations, theoretical test and case analysis of the interns in the experimental group [(83.58±5.68) points, (49.98±3.71) points, (33.60±2.28) points, respectively] were better than those of the interns in the control group [(80.28±6.04) points, (48.20±4.12) points, (32.08±2.06) points, respectively], with statistical significance ( P < 0.05). The results of the questionnaire survey showed that the interns in the experimental group were significantly more satisfied with the teaching than those in the control group in such aspects as active preparation before class, teaching methods, class participation and discussion, class interest, class effect and satisfaction, and the differences in active preparation, participation and interest were statistically different ( P < 0.05). Conclusion:In the process of orthopedics practice teaching, the teaching method of CBL based on WeChat platform can mobilize the enthusiasm and participation of students, and can improve the clinical teaching effect of orthopedics, which is worthy of promotion and application in practice teaching.