OBJECTIVE To investigate the distribution and drug resistance of clinical Pseudomonas aeruginosa (isolates),and offer reasonable experimental data for clinical therapy.METHODS A statistic analysis for the(specimen) source,departments with infection and drug resistance condition to 218 isolates was conducted in(retrospective) manner.RESULTS Among 218 strains 138(63.3%) come from sputum and throat mucus,and 25(11.5%) from wound swab;the proportion of these strains from ICU was 44.9%,from neurology department was 12.4% and from(respiratory) department was 11.5%.The result of drug susceptibility showed that P.aeruginosa had a high resistance rate to the ?-lactamases, aminoglycosides,fluoroquinolones and sulfanilamides(antibiotics),respectively,accounted for more than 50%,and had a lower resistance rate to carbapenem, ?-(lactamases) antibiotics/inhibitor,the lowest was to piperacillin/tazobactam(8.7%),and to cefoperazone/(sulbactam)(17.5%).CONCLUSIONS Clinical(isolates) of P.aeruginosa come from the sputum,(pharyngeal) swab and ICU mainly,but their resistant rates are rather high and multidrug-resistant.We should pay more attention to the surveillance of antimicrobial resistance of P. aeruginosa in clinics and prevent(transmission) and epidemic of their resistance strains.

Objective To study the distribution and drug resistance of clinical Providencia stuartii isolates and provide the basis data for clinical therapy.Methods A data analysis for the specimen source,the distribution of departments with infection and the antibiotic susceptibility results to 76 isolates was conducted in retrospectively. Results Among 76 strains were mainly from sputum (71.1%),wound secretions (10.5%) and blood (6.6%);the proportion of these strains from ICU was 40.8%,from respiratory department was 9.2%and from general surgery was 7.9%;The bacteria's drug resistance was more serious,multi drug resistant (MDR) strains accounted for 65.8%,pan drug resistant ( PDR) strains accounted for 26.3%,the mortality of patients with PDR strains infection was 45.0%,which was higher than 5.8%of no PDR strains infection.A low resistance rate of antibiotics were imipenem,fluoro-quinolones andamikacin,et al,and the rate of imipenem resistant was lowest(31.5%).Conclusion The multidrug resistance phenomenon of Providencia stuartii is serious, the first choice for the treatment is imipenem, the second choice was fluoroquinolones or amino glycopeptides antibiotics,the hospital infection caused by the bacterium infection in monitoring should be strengthened.