OBJECTIVE: To investigate the pathogenic bacteria distribution and drug susceptibility in children with acute otitis media (AOM) in different age and different season in the Pearl River Delta region. METHOD: Four hundred and forty-two children diagnosed as AOM were divided into three groups by age factor and four groups by season factor. Midge ear pus collecting and culturing were used for bacteria and antimicrobial susceptibility test. RESULT: (1) Strains of bacteria were isolated from 356 children with the positive rate of 80.5%. Streptococcus pneumoniae (39.2%), staphylococcus aureus (25.9%) and haemophilus influenzae (7.4%) were the most frequently isolated pathogens. (2) Streptococcus pneumoniae was the main pathogenic bacteria in 0-1 year group and > 1-3 years group (P < 0.05), staphylococcus aureus was the most frequently isolated pathogen in >3 years group (P < 0.05); (3) In the season groups, the number of children with AOM decreased significantly in July-September group. There was no significant difference of streptococcus pneumoniae distribution among the four groups (P > 0.05). Staphylococcus aureus was the main pathogen in January-March group (P < 0.05); (4) Drug sensitivity shown that linezolid and ofloxacin were most sensitive to streptococcus pneumoniae and staphylococcus aureus, and macrolides had a good therapy effect to haemophilus influenzae. CONCLUSION The pathogens distribution and drug susceptibility in children with AOM were varies in different age and different season. As a result, a treatment should be done based on the climate, environment, and pathogens distribution of a region.
Adolescent ; Anti-Bacterial Agents ; pharmacology ; therapeutic use ; Child ; Child, Preschool ; China ; epidemiology ; Female ; Haemophilus influenzae ; drug effects ; isolation & purification ; Humans ; Infant ; Male ; Microbial Sensitivity Tests ; Otitis Media ; drug therapy ; epidemiology ; microbiology ; Seasons ; Staphylococcus aureus ; drug effects ; isolation & purification ; Streptococcus pneumoniae ; drug effects ; isolation & purification

Objective To explore clinical efficacy and safety of Qiangdu-Nianwang decoction on patients with ankylosing spondylitis (AS) and the TCM syndrome of kidney deficiency. Methods A total of 112 patients with AS who met the inclusion criteria weredivided into two groupsby random number table method, 56 cases in each group. The control group was treated with conventional therapy, while the study group was given Qiangdu-Nianwang decoction. The two groups were treated for 1 months continuously. TCM syndromes, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Metrology Index (BASMI) was scored before and after treatment. The ELISA method was used to detect serum CRP level. The wechsler method was used to detect ESR. Aand clinical efficacy was evaluated. Results The total effective rate of the study group was 96.4％ (54/56) and the control group was 76.8％ (43/56). The difference between the two groups was statistically significant (χ2=9.314, P=0.002). After treatment, the scores of rachialgia, hypnalgia and total pain in the study group waswere significantly lower than those in the control group (t=8.980, 4.675, 9.686, P<0.01). The score of BASDAI, BASFI, BASMI and TCM syndromes was were significantly lower than those of the control group (t=14.117, 4.312, 7.665, 9.213, P<0.01). After treatment, the levelof ESR and CRP in the two groups was were significantly lower than those before treatment (P<0.05), and the levels of ESR and CRP in the study group was were significantly lower than those in the control group (t=9.128, 9.588, P<0.01). Conclusions The Qiangdu-Nianwang decoction on patients with AS and kidney deficiency has a good efficacy and low adverse reactions, can reduce the clinicalsymptoms, improve limb functions, and it was worthy clinical application.

Objective:To explore the clinical efficacy and safety analysis of a novel laser localization technology assisted percutaneous puncture of trigeminal nerve microsphere capsule compression surgery for the treatment of primary trigeminal neuralgia.Methods:A retrospective selection was conducted on 63 patients with primary trigeminal neuralgia who underwent percutaneous puncture of the trigeminal nerve microsphere capsule compression surgery at the First Hospital of Hunan University of Chinese Medicine from January 2020 to December 2021. According to different surgical methods, they were divided into a new laser localization assisted puncture group (observation group) of 32 cases and a traditional barehanded localization puncture group (control group) of 31 cases. An analysis was conducted on the surgical time, puncture time, puncture frequency, intraoperative exposure to radiation, number of cases of poor balloon formation, and clinical efficacy within 6 months after surgery for two groups of patients. The prognosis of the patients was followed up at 6 months after surgery.Results:The surgical time, puncture time, puncture frequency, and intraoperative exposure of the observation group were all less than those of the control group, and the differences were statistically significant (all P<0.05). There was no statistically significant difference ( P>0.05) in the number of cases of poor balloon angioplasty between the observation group and the control group, as well as the pain score grading of the Barlow Neurological Institute (BNI) on the first day after surgery. Within 6 months after surgery, there was no statistically significant difference in the incidence of facial numbness, diplopia, masseter weakness, perilabial herpes, and recurrent pain between the two groups of patients (all P>0.05). Conclusions:Laser positioning technology can assist in precise puncture of the foramen ovale and accurate placement of balloons based on surgical experience, which helps to improve surgical safety, reduce postoperative complications and intraoperative radiation dose, and achieve satisfactory short-term follow-up results.