Objective:To explore the situation of human parvovirus B_ 19 (HPV-B_ 19), cytomegalovirus (CMV) , Group A hemolytic streptococcal infections and immune function in children with tic disorders (TD).Methods:Sixty children with TD were involved in the study. HPV-B_ 19-IgM and CMV-IgM were examined using ELISA method. The titers of antistreptolysin O (ASO) was examined by agglutination. We also detected immune function, the ferrohemoglobin level, leucocyte count and platelet count of peripheral smear in the study. There were 20 healthy children as control group.Results:The positive rate of HPV-B_ 19-IgM (23.3%) were significantly higher than that of control (all are negative, ?2=5.67,P

Objective To explore the application of event related potentials (ERPs) in the comprehensive intervention for attention deficit hyperactivity disorder (ADHD) in children. Methods P 300 of ERPs and Conners' measuring scale were tested in 31 children with ADHD before and 6 months after comprehensive intervention. At the same time, P 300 was tested in 36 healthy children as control. Results In the children with ADHD, the P 300 latency was longer and amplitude was lower than those in the healthy children before comprehensive intervention (P

Objective: To explore the effects of early intervention on functional outcome and the repair mechanisms in rats with hypoxic-ischemic brain damage (HIBD). Methods: A HIBD rat model was established by ligating either uterine vessel of one pregnant horn. The way of intervention was the neonatal handling and enriched environment. One trial passive avoidance response, brainstem auditory evoked potential (BAEP) and NGF levels in the brain were used as assessment index. Results:(1) In the one trial passive avoidance response test, the medial step-through latency (STL) of intervention group (n=18) was much longer than that of non-intervention group (n=15) (P

Objective:To investigate the application effect of production-oriented approach (POA) for consulting ability teaching in general practice standardized residency training.Methods:Eighteen third-year general practice residents in the Second Affiliated Hospital of Harbin Medical University received a special training course on the consulting ability based on POA with the situational simulation teaching from September 2021 to March 2022. The consulting ability of residents was evaluated with Objective Structured Clinical Examination (OSCE) and Leichester Assessment Package (LAP) before and after the training, and the results were compared. Meanwhile, a questionnaire survey and semi-structured interviews were conducted to assess residents′ satisfaction with the course.Results:All 18 resident trainees (11 females and 7 males) aged 25 to 34 (27.3±2.4) years successfully completed the training. Both OSCE scores and LAP scores after the training were significantly higher than those before training (66.25±5.84 vs. 44.44±12.80, t=8.46, P<0.001; 65.78±7.05 vs. 38.33±14.2, t=1.47, P<0.001, respectively). The ability of medical history collection, physical examination, patient management, problem solving, doctor-patient relationship, preventive care and medical record writing were all significantly improved after the training compared with those before training ( t=2.464, 4.278, 8.997, 2.385, 10.35, 5.212, 7.578, all P<0.05). The questionnaire survey showed that all the 18 residents were satisfied with the reasonableness of the teaching content, the class time arrangement, the teaching progress arrangement and the instructors. In the dimension of training effectiveness, 18 participants all believed that the course was helpful to improve their humanistic quality and confidence in reception. In terms of self-promotion, all respondents believed that this course was able to promote their reflection ability and stimulate their learning interest. By coding and analyzing the contents of the semi-structured interviews with the residents, nine main themes were constructed, namely course deficiencies, course characteristics, course advantages, course suggestions, trainees′ deficiencies, trainees′ gains, trainees′ goals, previous teaching deficiencies, and instructor′s role. The results showed that all residents had a high degree of satisfaction with the course, and they thought the course was vivid and interesting and it is able to mobilize the enthusiasm of learning, promote learner to reflect. The residents also suggested to increase the teaching hours and to enrich teaching cases. Conclusion:The consulting ability training of general practice based on POA can effectively improve consulting ability, stimulate learning interest and improve independent learning ability of residents, which gains recognition from both faculty and trainees.