NM23A protein is a kind of multifunctional protein distributed widely in the nature and it exists in almost all the or-ganism and cells. Apart from owning the nucleoside diphosphate kinase activity, NM23A also participates in the physiological process of signal transduction, gene regulation, cell growth and development and so on. NM23A plays important roles in the pa-thology process of the tumor development and metastasis and cen-tral nerve system disease.

Proteins of the phosphatidylethanolamine binding protein(PEBP) family are highly conserved throughout nature and have multiple biological functions.These small,cytosolic proteins have a typical large central sheet and a putative ligand-binding site which shares an affinity for a variety of ligands such as phospholipids,opioids,nucleotides,hydrophobic odorant molecules.PEBP plays a pivotal modulatory role in Raf-1/MEK/ERK、I?B/NF-?B、GPCR signaling cascades.As the precursor of the hippocampal cholinergic neurostimulating peptide(HCNP),PEBP may play an important role in the septal cholinergic development of the hippocampal.In addition,PEBP has the potential to contribute to neural protection,biogenesis and refinement of the membrane,Alzheimers disease(AD),opioid dependence,diabetic nephropathy,cancer and other physiological or pathophysiological processes.

This study aimed at exploring the economic operation and developing trend of county-level public TCM hospitals in Guangxi Province,promoting the comprehensive reform of county-level public hospitals with feasible countermeasures and suggestions.In this study,forty-seven county-level public TCM hospitals were involved in the analysis of their economic operations and benefits by constituent ratio analysis,ratio analysis and trend analysis.As a result,the average gross income of the hospitals exceeded the total expenditure with a slight surplus.Drug income contributed the biggest share of the medical income,while the ratio of Chinese drug income to the medical income was increasing year by year.The debt ratio increased from 38.7％ in 2009 up to 44.6％ in 2013,being over 30％ in this period.In conclusion,it was demonstrated that problems were found in the lack of financial assistance,the low efficiency of economic management and the increasing average medical charges,which should be addressed by increasing investments to TCM hospitals,strengthening the performance appraisal and adjusting the charges of TCM medical services.

Objective To study the demand of general doctors'professional skill in Guangxi Zhuang autonomaus region,and to enhance the professional skills and overall quality of general practitioners in Guangxi,thus to improve grassroots'health service capacity.Methods Through self -designed questionnaires and personal interviews,the author investigated the professional skills of general practitioners in rural township hospitals and urban community health service centers in Guangxi.Results The characteristics of the general practitioners in Guangxi were junior college degree,junior titles,youth and middle -aged.Part of the general practitioners thought that working with the guide of community health informationteaching abilityand the corresponding scientific research capabilitiesdid not belong to the scope of the general practitioners'professional skills demand,the percentage of these were 2%, 22%,26%.The teaching ability and the corresponding scientific ability of the general practitioner who were greater than 30 years,junior college degree and middle grade title and above,were better than the practitioners who were 20 -30 years,technical secondary degree,primary title(χ2 =12.886,1.945,57.473,53.276,30.458,29.141,all P <0.05).The general practitioners in Guangxi had a light awareness of teaching,scientific researching and other aspects.Conclusion We must emphasis on continuous medical education;establish and improve the system of general practitioners;establish and improve the two -way referral system.General practitioners must pay more attention on teaching and scientific researching.

Objective To determine the test-retest reliability of functional squat system (FSS) isometric muscle strength tests for patients with knee osteoarthritis. Methods The isometric muscle strength of thirty patientswith knee osteoarthritis (21 males and 9 females; age 45 to 89 years, mean age 68.73 ± 12.19 years) was tested twice within 1 week by the same tester. Three test results were obtained: maximum isometric extension strength, the time to initiate isometric extension and the average isometric extension strength. Intra-class correlation coefficients (ICCs) for the three tests were computed to evaluate their retest reliability. Results The ICCs of the maximum isometric extension strength and average isometric extension strength of the uninvolved and involved extremities were respectively 0.87, 0.88, 0.92 and 0.89. The ICCs of the initiation time for the uninvolved and involved legs were respectively 0.25 and 0.41. Conclusion In these tests of patients with knee osteoarthritis using the functional squat system, both the maximum isometric extension strength and the average isometric extension strength had very good test-retest reliability. These two test results could be used as reliable guidance for treatment and rehabilitation of osteoarthritic knees.

ObjectiveTo examine the the inter-rater reliability of the Chinese version of Lequesne index as the effective treatment evaluation of patients with knee osteoarthritis.Methods30 patients with radiological findings and clinical symptoms of knee osteoarthritis were evaluated the Chinese version of Lequesne index twice by two staff who passed the Lequesne index formal training within 24 hours. Inter-rater reliability was assessed by the intra-class correlation coefficient (ICC) and the Bland & Altman method.ResultsInter-rater reliability was excellent with ICC=0.94. The Bland & Altman analysis revealed no systematic errors between inter-raters.ConclusionThe Chinese version of Lequesne index has high inter-rater reliability in subjects with knee osteoarthritis.

ObjectiveTo investigate the test-retest reliability about the lower extremities static joint position sense which was tested with the Tetrax balance-test-training system, and the dynamic joint position sense which was tested with the Functional Squat System; and to investigate the relationship between the static and the dynamic joint position sense of lower extremities of the patients with knee osteoarthritis. Methods30 patients with knee osteoarthritis were tested with the lower extremities static and dynamic joint position sense twice within 7 d with the Tetrax balance-test-training system and the Functional Squat System. ResultsThe intraclass correlation coefficient (ICC) of the sum of the coefficient of medium-to-high-frequency in postural sway was 0.95 (P<0.001). The ICC of the reposition accuracy error mean of the unaffected/mild or affected/severe extremity were respectively 0.59 and 0.60 (P<0.001). The Pearson correlation coefficients of the sum of the coefficient of medium-to-high-frequency in postural sway and the reposition accuracy error mean of the unaffected/mild or affected/severe extremity were respectively 0.40 and 0.54 (P<0.05). ConclusionThe lower extremities static joint position sense test of the Tetrax balance-test-training system is well reliable, as well as the dynamic joint position sense of the Functional Squat System. They can be used together to evaluate the lower extremities proprioception in the patients with knee osteoarthritis.

BACKGROUND:More recently, studies have demonstrated that bone marrow mesenchymal stem cel s can be induced in vitro to differentiate into neuron-like cel s that are used for in vivo transplantation to repair nerve damage.
OBJECTIVE:To study the effect of bone marrow mesenchymal stem cel transplantation on learning and memory ability of senile dementia rats.
METHODS:Thirty male Sprague-Dawley rats were randomly divided into three groups:normal control group, stem cel therapy group and model control group. Rats in the latter two groups were used to establish animal models of senile dementia by intracranial injection ofβ-amyloid 1-40. Three weeks after modeling, rats were given bilateral hippocampal injection of induced bone marrow mesenchymal stem cel suspension in the stem cel therapy group, whereas no treatment was given in the normal control and model control groups. Morris water maze test was used to detect learning and memory ability of rats, and rat’s brain tissues were detected pathological y using hematoxylin-eosin staining.
RESULTS AND CONCLUSION:After modeling, the escape latency was higher and the cross-platform frequency was lower in the model control group compared with the normal control group. After cel transplantation, the escape latency and cross-platform frequency were gradual y shortened and increased with time, respectively. Compared with the model control group, the learning and memory abilities of rats were improved in the stem cel therapy group. The brain tissues were relatively intact in structure and exhibited less cel degeneration and necrosis in the stem cel therapy group compared with the model control group. To conclude, bone marrow mesenchymal stem cel transplantation exerts certain therapeutic effects on senile dementia by effectively improving the learning and memory ability.

Objective To evaluate the effect of high-voltage electrostatic therapy on sleep disorder in the elderly. Methods 31 elderlycases (66~92 years ) with sleep disorder were treated with high-voltage electrostatic therapy for 10~15 d. They were assessed with PittsburghSleep Quality Index (PSQI) before and after the intervention. Results The global score and all the subscale scores of PSQI decreased(P<0.01) after intervention. Conclusion The high-voltage electrostatic therapy is effective on sleep quality.

ObjectiveTo assess the effect of the vestibular, visual, and somato-sensation on the fall risk in elderly individuals. Methods56 subjects aged 60 or over were measured with the static postural stability and fall risk, including stability index （ST）, the body weight distribution index (WDI) and the fall index (FI) under 4 conditions: standing on solid surface with eyes open （NO），standing on solid surface with eyes closed （NC）， standing on pillows with eyes open （PO），and standing on pillows with eyes closed （PC）. ResultsThe mean of fall index of all subjects was (48.21±26.47). The ST was different among groups, which was PC>PO>NC>NO （P=0.000），but no significant differences were noted between PO and NC groups （P=0.705）. The WDI was not significantly different among the 4 groups (P>0.05）. The FI was correlated with ST （P<0.05）, but not correlated with the WDI（P>0.05）. ConclusionAll of the vestibular, visual, and somato-sensory systems play an important role in the balance, postural stability and falls. The ST is sensitive to evaluate the static balance function and associated with the fall risk in an elderly population. The WDI is not sensitive enough to evaluate the static balance function and fall risk.