Objective To compare and analyze the occupational exposure limit（OEL）of hexavalent chromium compounds in China and foreign countries. Methods The OEL and background information of hexavalent chromium compounds released by nine official and unofficial organizations in seven countries/regions were collected and sorted. The classification，limit levels， formulation principles and compound characteristics labeling of OEL were compared. Results The OEL values published by nine organizations ranged from 0.000 02 to 0.050 00 mg/m3 . Among them，the limits of seven organizations（including China） did not clearly distinguish the soluble types of hexavalent chromium compounds；the limits of eight organizations（including China）were calculated in terms of chromium；seven organizations（including China）have only developed OEL for long-term exposure. The OEL of hexavalent chromium in China was 0.050 00 mg/m3 which is relatively loose. Its carcinogenicity label was consistent with international standards，its sensitization label was consistent with some countries，and its percutaneous absorption label had not been included in the characteristic labeling of limit values. Conclusion It is suggested that the OEL of hexavalent chromium in China should be revised timely，and the systemic adverse effects caused by percutaneous absorption of hexavalent chromium compounds should be focused on. At the same time，it is recommended to systematically adjust the management concepts and principles of all carcinogens.

Objective To explore the role and their relationship of Ki-67, VEGF and p27 expressed in adult patients with acute leukemia. Methods The expression of Ki-67, VEGF and p27 in bone marrow mononuclear cells (BMMNC) were analyzed by immunocytochemical staining, and their correlations of Ki-67, VEGF and p27 were statistically analyzed. Results The expression of Ki-67(42.48±25.78)% or VEGF (44.89±24.01)% on BMMNC from acute leukemia cells was significantly higher than that in the control (11.40±9.94)% or (16.90±12.54)% (P<0.01). But the expression of p27 (23.65±13.30)% was significantly lower than that in the control (50.23±22.68)% (P<0.01). The expressions of Ki-67 were positively correlated with and VEGF in patients with acute leukemia were positively correlated(r=-0.666, P<0.01), and the expressions of Ki-67 and p27 were negatively correlated with p27 in patients with acute leukemia (r=-0.316, P<0.05).Conclusion The evaluation of expression of Ki-67, VEGF and p27 on acute leukemic cells provides new insights to the pathogenesis is helpful in mechanism and is helpful in the diagnosis of acute leukemia.

ObjectiveTo evaluate the effect of the comprehensive rehabilitation training, including multi-joint isokinetic muscle strength, balance, and weight-support training, on the senile patients after total hip arthroplasty. Methods50 patients after total hip arthroplasty were divided into group A (n=25) and group B (n=25). The group A received the comprehensive rehabilitation training combined with the 3 systems, while the group B received the routine rehabilitation training. They were assessed with the Harris scale and the life satisfaction before and 4, 8 and 12 weeks after rehabilitation. ResultsCompared with that before rehabilitation, the Harris score of all the patients improved 8 weeks after rehabilitation (P<0.05), while it improved more in the group A than in the group B (P<0.05). The incidence of hip joint recovery was more in the group A than in the group B as well (P<0.05). The life satisfaction improved in both groups 4 weeks after rehabilitation (P<0.01), and it was more in the group A than in the group B 12 weeks after training (P<0.05). ConclusionThe rehabilitation combined with isokinetic, balance, weight-support training can promote the functional recovery after total hip arthroplasty

Aim To evaluate the time-course curve of expression of TRPC1 and vascular tone of pulmonary arteries(PAs)mediated by SOCE in chronic hypoxia pulmonary hyperte-nsion rats.Methods Both tension of PA rings and expression of TRPC1 were tested in CH exposure (1 0.0 % ±0.5 %partialpressure ofoxygen ) induced pulmonary hypertensive (PH)rats,and the time-course curve(detected respectively in CH 1 ,3,5, 7,1 4,21 d)was traced.Results ①CH could up-regulate the mean right ventricular pressure(mRVSP) ,which was increased significantly on 1 d,and reached the maximum on 7d;right ventricular weight index (RV-MI)began increase on 3d,and kept rising;②semi-quantitative reverse transcription polyme-rase chain reaction (RT-PCR)was performed to detect the expression of TRPC1 in PAs.The expression of TRPC1 increased significantly on 1 d,and reached the maxi-mum on 3d;③CH could up-regulate the vascular tone of PAs mediated by SOCE,which was increased signif-icantly on 3d,and reached the maximum on 7d.Con-clusions TRPC1 /SOCE increases significantly in the early days of CH,and the time-course curve of the two has correlation,which reflects the important role of the upregulation of TRPC1 /SOCE in the process of chronic hypoxia pulmonary hypertension.

OBJECTIVE: To investigate the risk factor,type and characteristic nystagmus of the otolith abnormal migration during diagnosis and treatment for posterior semicircular canal benign paroxysmal positional vertigo (PSC-BPPV). The therapy and prevention is also discussed. METHOD: Four hundred and seventy-nine patients with PSC-BPPV were treated by Epley's canalith repositioning procedures(CRP) from March 2009 to March 2012. We observed otolith abnormal migration complicating during diagnosis and treatment. According the type of otolith abnormal migration, the additional repositioning maneuver was performed. RESULT: The rate of complication was 8. 1%(39/479), with canal conversion in 5.4%(26/479) and primarily canal reentry in 2.7%(13/479). The rate of incidence of conversion to horizontal canal conversion and anterior canal were 4. 8%(23/479)and 0. 6%(3/479) respectively. All the patient was cured in follow up. The risk factors were unappropriated head movement during or after CRP, including another Dix-Hallpike were performed immediately. CONCLUSION To prevent the complications,the pathognostic positioning sequence and angle of head rotation are commenced during CRP. Appropriate short time postural restrictions post-treatment is necessary. Careful observation of nystagrnus variation is crucial to determine the otolith abnormal migration.
Benign Paroxysmal Positional Vertigo ; therapy ; Head ; Humans ; Incidence ; Nystagmus, Pathologic ; etiology ; Otolithic Membrane ; Patient Positioning ; adverse effects ; Semicircular Canals ; Vertigo

OBJECTIVETo investigate the eligibility and main problems for occupational health inspection agencies in China, and to provide technical references for improvement of occupational health inspection.

METHODSA survey was performed in occupational health inspection agencies that obtained eligibility before June 2011 in eight provinces: Zhejiang, Jiangsu, Shandong, Hubei, Guangxi, Shanghai, Chongqing, and Shenzhen. The survey used the General Information Questionnaire for Occupational Health Inspection Agency made by the project of Occupational Health Surveillance and Diagnosis and Identification of Occupational Diseases in China and Australia.

RESULTSA total of 650 agencies obtained eligibility for occupational health inspection in the eight provinces. These agencies contained 343 centers of disease control and prevention (CDC) or health and epidemic prevention stations (52.8%), 219 hospitals (33.7%), 25 institutes or centers for occupational disease prevention and control (3.8%), 29 community health service centers (4.5%), and 34 other agencies (5.2%) including departments of preventive and health care and preventive medicine outpatient departments. Four hundred and fifty-three agencies completed the questionnaire survey with a response rate of 69.7%. The main types of eligible agencies were different among various regions. A majority of occupational health inspection agencies were hospitals in Shanghai and Zhejiang (67.1%, 62.3%), departments of preventive and health care in Shenzhen (70.0%), and CDCs in Chongqing, Jiangsu, Hubei, and Guangxi. Each agency obtained 3.5 occupational health inspection eligibilities on average. Most of agencies could perform eligible health inspection for dust, harmful physical factors, or harmful chemical factors (84.8%, 87.9%, 87.2%). Moreover, 72.8% of agencies were eligible for all the three types of inspections. A few agencies were able to perform eligible health inspection for harmful biological factors or radiation work (22.5%, 23.0%).

CONCLUSIONAn occupational health inspection network has been established in these surveyed regions. CDCs, institutes for occupational disease prevention and control, and hospitals are the main agencies for occupational health inspection. In order to build up a network of occupational disease prevention and control, various agencies should make full use of their own advantages and enhance abilities and technical cooperation.

China ; Hospitals ; Humans ; Occupational Diseases ; epidemiology ; Occupational Health ; Occupational Health Services ; organization & administration ; Organizations ; Surveys and Questionnaires

Objective: To characterize the features of human brucellosis from national reports of occupational diseases and infectious diseases in China during 2006-2016, and explore the correlations between human brucellosis with the livestock and their products. Methods: From January to October 2018, the data of human brucellosis were extracted from China's annual national reports of occupational diseases and infectious diseases from government circulars during 2006-2016. The data on the number of livestock and the output of livestock products were obtained from China Statistical Yearbook, China Animal Industry Yearbook and China Animal Industry and Veterinary Yearbook. The standards of Diagnosis of occupational infectious disease (GBZ 227-2017) and Diagnostic criteria for brucellosis (WS 269-2007) were compared. The statistics were analyzed using Excel 13.0 and SPSS software 22.0. The linear regression and multiple regression were used to explore the relationships between human brucellosis with the number of livestock and the output of livestock products. Results: The diagnosis of human brucellosis in national reports of occupational diseases was based on GBZ 227-2017, which referred to WS 269-2007. There is an increasing trend from 2006 to 2009, and then declined to 2011, but rebounded from 2012 onwards in human brucellosis in national reports of occupational diseases. The general trend showed an increase during the 2006-2014 period, and then a decrease onwards in human brucellosis in national reports of infectious diseases. The Spearman correlation from SPSS showed the r_s value of 0.936 (P<0.001) between human brucellosis cases in national reports of occupational diseases and infectious diseases in China from 2006 to 2016. Human brucellosis had a seasonal and periodic trend, and the cases revealed an epidemic period from April to August, with a peak in June. Human brucellosis cases were positively correlated with the number of cattle and buffaloes, hogs, sheep and goats (P<0.05) , and the output of pork, beef and mutton (P<0.05) . And human brucellosis cases in national reports of infectious diseases were positively associated with the output of sheep wool (β=0.814) , goat wool (β=0.603) , and cashmere (β=0.562) . Conclusion Human brucellosis both in national reports of occupational diseases and infectious diseases remain severe in China. There are relationships between human brucellosis with the number of livestock and the output of livestock products.

Objective: To analyze the relevant literature on China’s occupational health standard from 2001 to 2016, and to provide a basis for further improving China’s occupational health standard system. Methods: Wanfang Data, CNKI, VIP, PubMed, Embase, and Web of Knowledge were used to retrieve relevant literature on China’s occupational health standard from 2001 to 2016. Information of the literature was collected, and type of literature, time and region, first author’s affiliation, and research funding were analyzed by bibliometrics. Results: The relevant literature on China's occupational health standard was concentrated domestically and in the health system, and the number of documents was highly correlated with socio-economic conditions. The literature was dominated by the research on onsite application of occupational health (53.08%) , while there was less research on occupational health standard (11.78%) . The number of published articles and funding intensity were significantly different between centers for disease control and prevention at different levels. Conclusion It is suggested to accelerate the application of evidence-based medicine and systematic review in the development of occupational health standard, enhance the research ability of county/district-level disease control officers, assist them in summarizing and publishing their daily work experience, and give them appropriate funding, so as to promote the accumulation of knowledge in the field of occupational health.

Objective: To understand the health literacy and healthy city satisfaction of residents in Ningbo,and to provide a basis for further development of healthy city . Methods: The permanent residents aged 15 years old and above in six urban districts of Ningbo were selected by stratified multi-stage sampling and probability-proportionate-to-size sampling method. The health literacy and healthy city satisfaction of residents were surveyed by a self-designed questionnaire. Multivariate linear regression model was used to analyze the correlation between health literacy and healthy city satisfaction . Results: A total of 3 300 people were investigated and 3 035 valid questionnaires were returned,with an effective rate of 91.97%. The scores of health literacy were 22.67±4.83 in males and 23.04±3.13 in females;the scores of healthy city satisfaction were 3.30±0.32 in males and 3.31±0.33 in females;there were no statistically significant differences in the scores above between genders（P>0.05）. The scores of health literacy were 25.65±4.14 in the residents aged 35-44 years and 20.34±3.54 in the residents aged 15-34 years;the scores of healthy city satisfaction were 3.16±0.32 in the former and 3.45±0.31 in the latter;the former scored higher in health literacy but lower in healthy city satisfaction than the latter （both P<0.05）. The scores of health literacy were 23.80±3.90 in the married residents and 18.94±3.22 in the single,divorced or widowed ones;the scores of healthy city satisfaction were 3.35±0.33 in the former and 3.22±0.32 in the latter;the former scored higher both in health literacy and healthy city satisfaction than the latter （both P<0.05）. The results of multivariate linear regression analysis showed that the higher the scores of health literacy,the higher the scores of healthy city satisfaction （β'=0.028,P<0.05） . Conclusion Improving health literacy of residents could improve their satisfaction with healthy city construction.

Summarize the application of SOAP in the medical field and find out its problems in the course of traditional Chinese medicine, to explore the significance and value of SOAP in teaching practice in TCM. Organize relevant literature and discuss the application of SOAP in the course of Chinese medicine. SOAP is widely used in various aspects of medicine, and there are still some problems in the course of TCM. The use of SOAP model for teaching and assessment has important practical significance and value in the course of Chinese medicine internal medicine practice, and SOAP emphasize the practice of the post competence oriented teaching, which is worth promoting.