Objective:To explore the nursing effect of positive psychological intervention based on PERMA model for patients with depression.Methods:From January 2019 to December 2020, 120 depression patients admitted to Wenzhou Seventh People's Hospital were selected as the research object. According to the random number table method, the patients were divided into the control group and the intervention group, 60 cases in each group. The control group was given routine nursing, and the intervention group received positive psychological intervention based on the positive emotions, engagement, relationships, meaning and accomplishment (PERMA) model. Before and after the intervention, the Montreal Cognitive Assessment (MoCA) , Wechsler Memory Scale Revised China (WMS-RC) , and Hamilton Depression Scale-17 (HAMD-17) were used to evaluate the cognitive function, memory ability, and depressive symptoms of the two groups of patients.Results:After the intervention, the 7 dimensions and total scores of MoCA and the WMS-RC dimension scores in the intervention group were higher than those in the control group, and the HAMD-17 scores were lower than those in the control group, and the differences were statistically significant ( P<0.05) . Conclusions:The positive psychological intervention based on the PERMA model applied in depression patients can effectively improve the cognitive ability, memory ability and the drepressive symptoms of patients.

The dorsal lingual epithelium, which is composed of taste buds and keratinocytes differentiated from K14⁺ basal cells, discriminates taste compounds and maintains the epithelial barrier. N6-methyladenosine (m⁶A) is the most abundant mRNA modification in eukaryotic cells. How METTL3-mediated m⁶A modification regulates K14⁺ basal cell fate during dorsal lingual epithelium formation and regeneration remains unclear. Here we show knockout of Mettl3 in K14⁺ cells reduced the taste buds and enhanced keratinocytes. Deletion of Mettl3 led to increased basal cell proliferation and decreased cell division in taste buds. Conditional Mettl3 knock-in mice showed little impact on taste buds or keratinization, but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation recovery. Mechanically, we revealed that the most frequent m⁶A modifications were enriched in Hippo and Wnt signaling, and specific peaks were observed near the stop codons of Lats1 and FZD7. Our study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation.
Animals ; Epithelium/metabolism* ; Homeostasis ; Methylation ; Methyltransferases/metabolism* ; Mice ; RNA ; Taste Buds/metabolism*