The effects of butyric acid on cloned human lung cancer cells (PLA-801D) were observed with flow cytometry (FCM) and the conventional methods to identify the biological characteristics of cell lines. Butyric acid ( 2 or 3 mmol/L)treatment could result in an inhibition of the cell division and the growth rate of the cells,the blocking of the cell cycle progression in the Gl phase,a prolongation in doubling time, a shortening in saturation time, a decrease of saturation densities,and a reduction of plating efficiency. At the same time,there were some normal phenotypes of the cells such as flattening, tendency to grow in a monolayer,weakening of surface membrane activities, regularization of nuclei, and increasing of intercellular junctions.These findings suggest that after the treatment of butyric acid, the cancer cells (PLA-801D) appeared to acquire relatively normal growth properties and phenotypes. Thus, butyric acid, to a certain extent, can induce differentiation of PLA-801D cells, and be a potential anticancer agent.

Objective To investigate the way of improving the diagnosis and cure rate of pulmonary synovial sarcoma.Methods One case of pulmonary synovial sarcoma was selected,at the same time accompanied with 80 cases of pulmonary synovial sarcoma with complete data referenced from China Journal Full-text Database on October 2012 were retrospectively studied.The main clinical manifestations,imaging characteristics were analyszed.According to the pathology,immunohisochemistry and molecular biology for diagnosis and discrimination,in order to reduce the misdiagnosis.Results All of 81 patients,40 male cases and 41 female cases,the main clinical manifestations were chest pain,difficult breathing,hemoptysis and cough.In individual cases without any discomfort.All cases had not been accurately diagnosed before surgery.Ultimately diagnosis of patients depend on histopathology and immunohistochemistry.Conclusions Pulmonary synovial sarcoma shows different clinical symptoms but specific imaging characteristic and maybe confused with other pulmonary tumors or inflammation.Histopathological,immunophenotypic and fusion gene detection is the mainly technics for diagnosis.Surgery is the primary therapy,patients undergoing uncompletely resection have a poor prognosis.

Objective To develop and validate a qual it y of life(QOL) scale for the Chinese patients with uterocervical cancer (QOL-UC C). Methods Based on the internationally accepted de finition of QOL and the clinical characteristics of uterocervical cancer as wel l as the existing QOL scales, we designed the QOL-UCC. Then 113 patients were r ecruited and the reliability, validity and feasibility of the scale were tested. Results It was shown that the QOL-UCC had good reli ability, validity and feasibility. Conclusion QOL-U CC is a reliable and valid instrument for evaluation of the QOL in Chinese pa tients with uterocervical cancer.

Objective To investigate the quality of life (QOL) of cervical cancer patients and its influential factors as well as to explore the method for improving the QOL in this population of patients. MethodsA QOL questionnaire for uterus cervical cancer (QOL-UCC) was designed and used in a survey of 81 UCC patients before they got any treatment and 124 UCC patients after they were treated for a period of time. SPSS 9.0 software was used to analyze data. ResultsThe patients got poor score with psychological status items(2.11? 0.34 ) before treatment, while those who had been treated for a period of time got poor score with social characteristics items(2.01? 0.33 ), especially with the work(1.87)and sexuality (1.00) items. Economic status of the patients, unsuccessful control of progress of the disease and recurrence were the main influential factors of the QOL in the UCC patients. ConclusionPsychosocial factors play very important roles in QOL of the UCC patients. As a result, psychosocial interventions should be stressed in the rehabilitation of this population of patients.

[Objective] To analyze the experience and methods of removal the non-metal ic foreign bodies in the superficial tissue under the location of ul-trasonic and the guidance of acupuncture needle. [Method] First find the non-metal ic foreign bodies and observe the trauma around them by ultrasonic scanning, then use needle to puncture and approach the foreign bodies gradual y for location. Remove the foreign bodies according to the guidance of nee-dle in the end. [Result]Total foreign bodies could be removed easily without any remains in these cases, and trauma recovered wel . 33 cases were removed out smoothly the non-metal ic foreign bodies for just one time, and 1 case for two times. [Conclusion] Removal of the superficial non-metal ic foreign bodies under the location of ultrasonic and the guidance of needle is a great method of security,operating simply,being worthy of popularization through comparing with other methods.

B-cell receptors play an important role in the mechanism of chronic lymphocytic leukemia.Distinct CLL B-cell receptors exhibit particular biological features and behaviors to specific modes of microenvironmental interactions leading to clonal evolution and adverse outcome.

Objective To discuss MRI scan in the diagnosis and clinic-pathology of ovarian cystoid-material lesion.Methods We retrospectively analyzed 41 patients with clinic pathologically-proved in 2005~2007,and analyzed US,MR scan and Gd-DTPA in the diagnosis of ovarian cystoid-material lesion.Results The clinical date of the 87 patients were completed.After operation,41 of them were confirmed by pathology to be cystiform or parenchymal process,with age 16~76,average 56,of which,21 cases,were tumour-like lesions occupying 51.2%,18 cases were timorous lesions,occupying 30.2%,13 cases weer ovarian cystadenoma,occupying 30.2%,and 2case ueve other disense,occupying 4.65%.Conclusion The benign often present as ovarian cystoid-material lesion.MRI scan can show the inner structure of ovary lesion.

Surgical resection is the best way to treat liver cancer,but the effect of tumor with post-operational metastasis and relapse post-operational was severely restricted.Metastasis and relapse of hepatocellular carcinoma(HCC) is not only a serious threat to people' s health,but also a heavy burden to the family and society.The recognized marker of HCC now is AFP,but the lack of specificity and the bionomics limit it to be the marker of metastasis and relapse of HCC.With the developing of gene technology,AFP mRNA,the prosoma of AFP,is used as a marker of monitoring the metastasis and relapse of HCC.We review AFP mRNA monitoring in HCC with metastasis and relapse.

The validity of moral education is the emphases and difficulty that current research and academic studies focus on.Taken the concept of validity as the basic point,this article analyzes the deep-seated reason why the medical ethics education loses its validity and discusses the rules to realize the validity of the medical ethics education from the aspects that the medical ethics education should return to real life,adapt to psychology laws and penetrate through the clinical stage.

Objective To assess the courses of evidence-based medicine among graduate students. Methods A sample of 118 graduate students who took the course were surveyed twice by using the same self-designed questionnaire at the beginning and the end of the course.Pre-post comparison was conducted to measure the impact. Results The students were able to grasp the most of the contents of the course,and reshaped their opinions on evidence-based medicine,with which,a positive impact on their medical practice was expected. Conclusion The course of evidence-based medicine for graduate students has resulted in a positive consequence.