OBJECTIVETo explore the alone and joint diagnostic value of serum golgi protein 73 (GP73), alpha-fetoprotein (AFP) and the percentage of lectin-reactive aipha-fetoprotein (AFP-L3) of primary hepatic carcinoma (PHC), and provide a novel method for diagnosis for PHC and screening for high-risk population.

METHODSELISA was used to detect the serum level of GP73, AFP and AFP-L3% in 81 cases of PHC,176 cases chronic hepatitis and liver cirrhosis, 30 cases other tumber cancer and 40 cases of health people.

RESULTSThe sensitivity of GP73, AFP and AFP-L3% in PHC is 77.78%, 62.69% and 51.85%, and the specificity is 84.55%, 86.99% and 96.34%, respectively. Joint detection could increase the sensitivity up to 88.89%.

CONCLUSIONGP73 was a high sensitivity mark for dignosis of PHC, while AFP-L3% was a high specificity mark for dignosis of PHC. The joint detection could improve PHC diagnostic performance.

Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor ; blood ; genetics ; Carcinoma, Hepatocellular ; blood ; diagnosis ; genetics ; metabolism ; Diagnostic Tests, Routine ; methods ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms ; blood ; diagnosis ; genetics ; metabolism ; Male ; Membrane Proteins ; blood ; genetics ; Middle Aged ; Protein Isoforms ; blood ; genetics ; metabolism ; Young Adult ; alpha-Fetoproteins ; genetics ; metabolism