Objective To investigate blood gas analysis and lactic acid evaluation in aerobic forearm exercise and the significance of aerobic forearm exercise for the auxiliary diagnosis of mitochondrial myopathy and encephalopathy patients.Methods Forty-two patients with mitochondrial myopathy and encephalopathy patients, 40 healthy control, and 40 patients control were studied.They performed a protocol under aerobic exercise conditions, consisting of intermittent forearm exercise for 4 minutes at 40% of intented maximal voluntary contraction force.Blood samples were collected to monitor blood gas and plasma lactate before, during arid after exercise.Results During exercise venous PO_2(mm Hg, 1 mm Hg=0.133 kPa)decreased in mitochondrial myopathy and encephalopathy patients from 41.2?12.6 to 39.5?16.2, whereas PO_2 fell from 50.5?14.4 to 30.8?13.1 in healthy control and from 50.1?7.9 to 44.3?35.5 in patient control.Venous PO_2 decreased much more in healthy control group than the other 2 groups(F= 6.34,P

Objective To study the PICC daily maintenance behaviors of patients and find out the related factors.Methods Data was collected by questionnaires from 104 patients who had PICC and stayed in hospital between 2009.12～2010.5.Results Patients had much knowledge on basic PICC daily maintenance,while to the complications related knowledge of PICC was low,so was the knowledge of push contrast medium by PICC.PICC daily maintenance activities was positively related with the time with PICC,education level,and the number of children(P<0.05).Conclusions The patients with PICC need better and further health edueation to improve their behaviors of PICC daily maintenance and reduce the incidence of PICC complications.

Objective To study the effects of Yiqi Huayu Jiedu Prescription on the migration ability of MHCC97-H and the expressions of CXCL12, CXCR4 and CXCR7; To discuss its relevant mechanism of action. Methods Setting Sorafenib as a positive control, CCK-8 method was used for determining the effects of Yiqi Huayu Jiedu Prescription on the cell proliferation of MHCC97-H and the optimum concentration. Scratch assay was used to observe the migration ability of MHCC97-H. The protein expressions of CXCL12, CXCR4 and CXCR7 were detected by Western blot after 24 h of medicine intervention. Results Yiqi Huayu Jiedu Prescription and Sorafenib can inhibit the cell proliferation of MHCC97-H , and the inhibitory concentration was 0.095 g/mL and 10 μmol/mL at 24 hours. Yiqi Huayu Jiedu Prescription can inhibit migration ability of MHCC97-H. The protein expressions of CXCL12, CXCR4 and CXCR7 in hepatocellular carcinoma cells decreased after the action of Yiqi Huayu Jiedu Prescription. Conclusion Yiqi Huayu Jiedu Prescription can inhibit MHCC97-H cell proliferation and migration, which may be realized by down-regulating chemokine axis of CXCL12/CXCR4/CXCR7.

Objective To understand the prevalence of urinary incontinence(UI) and its related factors so as to develop a three-tier program for prevention of the disease.Methods A cross-sectional study was carried out in two townships of Jixian county,Tianjin,during July to November 2007.A total of 743 people aged 60 years and over were selected under cluster sampling,and all information were collected with a standardized structured questionnaire by face-to-face interview.All the data were analyzed with multivariate logistic regression method to explore the related factors for UI in the elderly.Results The overall prevalence of UI was 33.38 percent among people aged 60 years and over in two townships.Risk factors flor UI in men would include older age (OR=1.39).occupation(OR=5.00),awareness of UI(OR=1.91),having in chronic respiratory diseases(OR=2.23),prostate(OR=11.47),neurological(OR=11.76),or motor systems (OR=2.48).while protective factors would include high educational level(taking primary school or below as control group),OR for the junior middle school group appeared to be 0.35,for senior middle school group it was 0.77.and ofundergraduate group it was 0.53.Risk factors for UI in women would include older age(OR=1.31),constipation(OR=1.46),awareness of UI(OR=1.94),increased bodv nlass index(when normal weight group served as control group,OR in the overweight group was 1.03 and in the obesity group OR was 1.54),suffering from chronic respiratory diseases(OR=4.84).diabetes mellitus(OR=2.36),or motor system diseases(OR=1.37),more gravidity(OR=1.03),more parity(OR=1.02),suffering from perinea laceration(OR=1.72) and wound infection during delivery(OR=1.65),while protective factors would include physical exercises(OR=0.64).Conclusion Prevalence of UI was higher among the elderly people in rural areas of Jixian county,Tianjin.UI in the elderly might have been influenced by various factors which suggesting the intervention strategy should be targeted at those related factors as well as focusing on primary prevention.

Objective To explore the risk factors on chronic diseases related to falls in the urban-community elderly and to provide evidence for developing a three-tier program for prevention. Methods A cross-sectional study was conducted in one community of Beijing. People aged 60 years and over were selected, using a stratified cluster sampling method, and data on falls within the past 12 months and falls-related chronic diseases were collected through face-to-face interview. Results The incidence of falls was 18.0% within one year among the 1512 interviewees. Seven factors showed statistical significances through univariate analysis including diabetes mellitus (OR =1.62), postural hypotension (OR=1.84), hypertension (OR=1.48), cerebral infarction (OR=1.98), cataract (OR=1.56), osteoarthritis (OR=1.50), dementia (OR=5.34) and depression (OR=4.61). Data from multivariate logistic regression analysis showed that the risk factors for falls would include dementia (OR=4.82), depression (OR=4.27), postural hypotension (OR=1.92) and suffering from several kinds of chronic diseases etc. Conclusion The incidence of falls in an urban elderly community of Beijing was considered to be high. The risk of falls was higher among persons suffering from dementia and depression and having more than two kinds of chronic disease. The chances of falls would parallel the increase of several kinds of chronic diseases among the elderly, suggesting that measures should be actively taken to prevent from falls.

Objective To observe the clinical efficacy and safety of sitagliptin tablets combined with insulin detemir injection in the treatment of senile type 2 diabetes mellitus (T2DM).Methods A total of 120 elderly patients with T2DM were randomly divided into control group and treatment group with 60 cases per group.Two groups received subcutaneous injection of insulin detemir once a night with initial dose of 0.2 U · kg-1.Control group received oral repaglinide 0.5-2.0 mg tid.Treatment group was given oral sitagliptin 100 mg qd.Two groups were treated for 12 weeks.The clinical efficacy,levels of blood glucose and adverse drug reactions were compared between the two groups.Results After treatment,the total effective rates of treatment and control groups were 95.00％ (57/60 cases) and 76.67％ (46/60 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:the 2-hour postprandial blood glucose (2hPG) were (8.20±1.14),(9.87 ±1.64)mmol · L-1;the insulin dosages were (20.81 ±6.32),(39.86 ±5.40) U · d-1;hyperglycemia time ratios were (2.26 ± 1.85)％ and (15.93 ± 10.76)％ for 2 h PG ＞ 11.1 mmol · L-1;hypoglycemia time ratios were (2.64 ± 1.99)％,(3.60 ±2.84)％;blood glucose fluctuation coefficients were 1.50 ± 0.26 and 2.47 ± 0.39,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions were based on hypoglycemia in two groups.The incidence rates of hypoglycemia were 1.67％ and 10.00％ in treatment and control groups with significant difference (P ＜ 0.05).Conclusion Sitagliptin tablets combined with insulin detemir injection can effectively control the blood glucose on the elderly patients with T2DM,decrease the fluctuation of blood glucose,and reduce the incidence of hypoglycemia.

Objective To investigate the PICC daily maintenance behavior and self-efficacy of cancer patients. Methods 104 patients with PICC in hospital were investigated by questionnaire. Results 90% patients had knowledge on basic PICC daily maintenance, and the self-efficacy of these patients was above the moderate level. PICC daily maintenance activities was positive related with the time with PICC, education level,the number of children and self-efficacy (P ＜ 0. 05). Conclusions The patients with PICC need better and further health education to improve their behaviors of PICC daily maintenance and self-efficacy.

OBJECTIVETo evaluate a new technique to treat severe maxillofacial deformity and dysfunction of occlusion after the maxillofacial fractures.

METHODSThirty-four consecutive patients, with delayed maxillofacial deformities and dysfunction of occlusion after the maxillofacial fractures, were treated by the use of x-ray cephalometric analysis, model surgery, open reduction and rigid internal fixation.

RESULTSThirty-three patients were successfully corrected the maxillofacial deformities, facilitated normal occlusal relationship. Only one patient with severe damage of the brain was presented a mild occlusion dysfunction one year after the operation.

CONCLUSIONSThe above-mentioned technique may be a viable and effective option for the management of the deformities of the face and dentition after the maxillofacial fractures.

Adult ; Aged ; Female ; Follow-Up Studies ; Fracture Fixation ; methods ; Fracture Fixation, Internal ; methods ; Humans ; Male ; Maxillofacial Abnormalities ; surgery ; Maxillofacial Injuries ; surgery ; Middle Aged ; Oral Surgical Procedures ; methods ; Orthopedic Procedures ; methods ; Treatment Outcome

OBJECTIVETo understand the prevalence, consequences and risk factors of falls among urban community-dwelling elderly in Beijing.

METHODSA cross-sectional study was conducted in Longtan Community, Beijing. A total of 1512 individuals aged 60 years or over were selected by stratified cluster sampling. Data regarding the frequency of falls in the previous year, as well as circumstances, consequence and related factors of falls were collected from the elderly through face-to-face interviews with questionnaires in their home.

RESULTSThe prevalence of falls was 18.0% on the average among 1512 participants, higher in women (20.1%) than in men (14.9%) (P = 0.006), and increased with age (chi2(for trend) = 10.37, P = 0.001). The total rate of falls-induced injuries among the fallers was 37.7%. Falls usually resulted in soft-tissues bruises (58.7%), fear of repeated episodes of falls (58.8%), loss of independence and confidence in movement (35.7%) and even in hip fracture. In addition to the burden of medical care, falls also generated a big economic burden. Occurrence of falls was significantly associated with both intrinsic and extrinsic factors. The related factors of falls in the elderly included age > or = 60-70 years, femininity, less physical activities, fear of future falls, living alone, severely impaired vision, health problem-impacted activities of daily living, chronic diseases (diabetes, hypertension, postural hypotension, stroke sequela, cataract, arthritis, dementia and depression), medications (psychoactive, anti-diabetic), gait imbalance, high bed and faintly-lighted stairway.

CONCLUSIONThe prevalence of falls among urban community-dwelling elderly in Beijing is closely associated with significant associated with intrinsic and extrinsic factors. Efforts to prevent falls in the elderly should be made at community level.

Accidental Falls ; prevention & control ; Aged ; Aged, 80 and over ; China ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Risk Factors

According to the professional characteristics of the operating room,on the basis of basic principles of hierarchical management and post management of nursing department,taking clinical needs as guiding ideology,combined with the development needs of surgical departments,we developed the operating room nursing staff management model,and set up 23 jobs.We adjusted it accordingly in practice,and constantly optimized nurses' career plan by providing clinical,teaching,research,management and other multi-channel development direction,meanwhile provided better quality care for patients.