1.Losartan reduces cardiomyocyte apoptosis in rats with heart failure
Basic & Clinical Medicine 2009;29(11):1207-1210
Objective To find the inpact(s) of Losartan on myocardial apoptosis in rats with heart failure. Methods Eight-week-old male SD rats were divided into control group (group C) , heart failure (group HF) and treatment group (group LS). Use of doxorubicin injection model, group LS at the same time in a row to the oral losartan, myocardial ultrastructure was examined by TEM. DNA-situ terminal labeling (TUNEL method) was used to detect myocardial apoptosis and myocardial BAX, BCL-2 protein expression was detected by immunohistochemistry. Results Group HF showed significant myocardial cell injury, and apoptotic bodies were found, serum CPK, CK-MB and LDH were increased. In LS group, myocardial apoptosis index was lower (P <0. 01) , myocardial cells BCL-2 expression, BAX expression reduced as compared with those in HF group. Conclusion Losartan can effectively inhibit the process of heart failure occurred in cardiomyocyte apoptosis, reverse myocardial damage and improve the prognosis of heart failure.
2.Losartan reduces cardiomyocyte apoptosis in rats with heart failure
Basic & Clinical Medicine 2006;0(11):-
Objective To find the inpact(s) of Losartan on myocardial apoptosis in rats with heart failure. Methods Eight-week-old male SD rats were divided into control group(group C),heart failure(group HF) and treatment group(group LS). Use of doxorubicin injection model,group LS at the same time in a row to the oral losartan,myocardial ultrastructure was examined by TEM. DNA-situ terminal labeling (TUNEL method) was used to detect myocardial apoptosis and myocardial BAX,BCL-2 protein expression was detected by immunohistochemistry.ResultsGroup HF showed significant myocardial cell injury,and apoptotic bodies were found,serum CPK,CK-MB and LDH were increased. In LS group,myocardial apoptosis index was lower (P
4.Application of the Serum Protein Changes and it′s Protein Electrophoretic Analysis in Patients with Fever of Unknown Origin.
Jicheng XING ; Yuerong ZHU ; Hong QIU
Journal of Medical Research 2006;0(02):-
Objective To study the diagnostic value of detecting pre-albumin,albumin and protein electrophoresis in the serum of patients with fever of unknown origin.Methods Serum pre-albumin,albumin and protein electrophoresis were detected in 86 patients with fever of unknown origin and 26 controls.Results The level of albumin and pre-albumin in fever of unknown origin group was lower than that of control group(P
5.Effects of smoking on nicotinic acetylcholine receptor subunits expression in peripheral blood mononuclear cells
Bin XIONG ; Yuerong ZHU ; Hong QIU
Medical Journal of Chinese People's Liberation Army 2001;0(12):-
Objective To investigate the expression of nicotinic acetylcholine receptor (nAchR) subunits, and the effects of smoking on its expression in peripheral blood mononuclear cells (PBMCs). Methods Blood was collected from 92 healthy male smokers and 36 healthy male non-smokers. Peripheral blood monocytic cells were obtained, and reverse transcription-polymerase chain reaction (RT-PCR) was employed to study the gene expression of 11 nAchR subunits (?2-?7, ?9, ?10, ?2-?4). Results The results showed that the PBMCs of smokers and non-smokers appeared to express ?2, ?5, ?6 and ?7 only out of 11 nAchR subunits. However, the expression of ?5 and ?7 subunits was lower in smokers′ PBMCs than in non-smokers′ (P
6.INFLUENCE OF EXUDATES OF AMMONIUM-RESISTANT N_2 -FIXING BACTERIA ON THE GROWTH OF RICE SEEDLING
Ming-Qi QIU ; Qiu-Yan LU ; Hong-Hui ZHU ; Xiao-Ying QIU ; Yuan-Sheng QIU ;
Microbiology 1992;0(04):-
By using cup culture, influence of different strains (ammonium-resistant N2-fixing type, wild type, none N2-fixing type) of Klebsiella oxytoca on the growth of rice seedling was compared. It was discovered that ammonium-resistant N2 -fixing bacteria could excrete some plant growth promoting substance, which could be adsorbed by cation resin. It' s activity wouldn't be affected at 80℃. At optimal concentration, the weight of rice root and seedling were increased by
7.STUDY ON HIGH-DENSITY CULTURE OF AMMONIUM-RESISTANT N_2-FIXING BACTERIUM KLEBSIELLA OXYTOCA
Qiu-Yan LU ; Xiao-Bao XIE ; Hong-Hui ZHU ; Xiao-Ying QIU ; Ming-Qi QIU ; Yuan-Sheng QIU ;
Microbiology 1992;0(02):-
Based on the physiological properties of ammonium-resistant N2-fixingbacterium ( Klebsiella oxytoca NG13/pMC73A), the fermentation technology of it was studied. The basic medium of high-density culture was established, with glucose as carbon source coupled with appropriate nitrogen source and inorganic salts. At the middle and late phase of culture, glucose and ammonia were added to supply carbon source and nitrogen source, stabilizing the pHat 6.5 ~ 6.8. Optimal level of dissolved oxygen was kept by controlling aeration and stirring rate. Bacterium number of Klebsiella oxytoca NG13/pMC73A reached 600 ~ 700 x 10s cfu/mL at the end of culture. Compared with previous technology, bacterium number was increased by more than ten-fold with a comparable culture period.
8.Studies of the expression of CD40~+、CD40L~+ and CD8~+/CD28~+ on peripheral blood cells in patients with chronic B hepatitis
Liann QIU ; Yonglie ZHOU ; Hong YU ; Lijun ZHU ; Hongbo LI
Chinese Journal of Immunology 1985;0(02):-
0.05).There was a positive corrlation on CD40~+ and CD40L~+ in chronic B hepatitis patients.There was a positive corrlation on CD8~+/CD28~+ and CD40~+、CD40L~+ in chronic B hepatitis patients.There were no remarkable corrlation on CD8~+/CD28~- and CD40~+、CD40L~+ in chronic B hepatitis patients.Conclusion:The costimulation molecules CD40~+、CD40L~+ and CD8~+/CD28~+ are lower,while CD8~+/CD28~- are higher in chronic B hepatitis patients than in the health.To test the expression of CD40~+、CD40L~+ and CD8~+/CD28~+ on peripheral blood of the chronic B hepatitis could help to evaluate patients's celluar immunity and guide clinical treatment.
9.A case of coloboma of optic nerve in newborn.
Li-hong LI ; Na LI ; Jing-qiu ZHU
Chinese Journal of Pediatrics 2011;49(5):380-380
Coloboma
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Humans
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Infant, Newborn
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Male
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Optic Nerve
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abnormalities
10.Influence of perioperative protection from hypothermia on surgical site infection in patients under-going gastroenteritic operation
Xiaoling XIE ; Xiaohong HUANG ; Yanhua ZHU ; Hua HONG ; Weiting QIU
Chinese Journal of Practical Nursing 2008;24(30):9-11
Objective To explore influence of perioperative protection from hypothermia on surgical site infection (SSI) in patients undergoing gastroenteritic operation. Methods A retrospective study was carried out in 1536 patients undergoing gastroenteritic operation in general surgery department of our hos-pital.Patients (764 cases) admitted before July 2006 were set as the control group,while those after July 2006(772 cases) were set as the observation group. The observation group received a series of measures for protection from hypothermia besides of routine perioperative nursing.The control group only adopted routine perioperative nursing.The SSI rate was compared between the two groups. Results The SSI rate of the observation group was lower than that of the control group(P < 0.01 ). Conclusions Incidence of periop-erative hypothermia in patients undergoing gastroenteritic operation can increase the SSI rate.Appropriate measures for protection from hypothermia can prevent the incidence of hypothermia as well as SSI.