Objective To study the relationship between viral infection and chronic obstructive pulmonary disease (COPD),and the effect of viral infections on the changes of Th1/Th2 in COPD patients. Methods The se-ra from 81 patients with acute exacerbations of COPD,25 patients with stable COPD and 22 healthy subjects were tested for specific IgM of respiratary syncytial virus(RSV) ,herpes simplex virus type 1 (HSV-1), parainfluenza vi-rus (PIV), adenovirus (ADV) and cytomegalovirus (CMV) by indirect enzyme-linked immunosorbent assay (ELISA). Supernatant INF-γ and IL-4 cultured with PHA were determined. Results The positive rates of IgM in patients with acute exacerbations of COPD compared with those in patients with stable COPD and healthy subjects were significantly different(P <0.001 ). The level of INF-γ, and IL-4 in patients with acute exacerbations of COPD and stable COPD compared with normal control group;the level of INF-γ (242±43) and the of IL-4(42±9) in pa-tients with acute exacerbations of COPD was not significantly different as compared with the level of INF-γ( 198±32) and the level of IL-4(56±11 ) in patients with stable COPD (P<0.05), but the level of INF-γ was increased (90±18)and IL-4 was decreased (141±24) in control group (P<0.05). Compared with those in IgM negative group, the levels of INF-γ were significantly higher and the levels of IL-4 were significantly lowerIL-4 in lgM positive group( P<0.01 ). Conclusion Virus infection is a rather important factor in acute exacerbations of COPD, and COPD is characterized by a predominance of Th1-type response,and there is more significant Th1 response predomi-nance in COPD with virus infection.

Objective:To explore the association between long-term low-dose radiation exposure and other influencing factors with the risk of lens opacity on medical radiation workers.Methods:In July 2019, a retrospective cohort study was conducted by collecting the basic demographic information, dose data and health inspection result of 2708 radiologists in 22 hospitals of Guangzhou from the Occupational Health Inspection Information System and the Personal Dose Monitoring System of the Guangdong Prevention and Treatment Center for Occupational Disease between 2010 to 2018. The association between the average annual effective dose and lens opacity risk was calculated by using Time-Dependent Cox Regression Model.Results:From 2010 to 2018, the incidence density of lens opacity was 185.90/10000 person years. Compared with the radiation workers in the age <30 years group (93.74%) , the 5-year normal rate of lens in the age ≥50 years group (72.51%) was lower ( P<0.01) ; Compared with the radiation workers in the exposure age <10 years group (92.69%) , the 5-year normal rate of lens in more than 20 years exposed group (83.05%) was lower ( P<0.01) . Multifactor analysis showed that age was an independent influencing factor for lens opacity in medical radiation workers ( HR=14.485, P<0.01) . The risk of lens opacification increased by 4.9%, 10.1% and 15.5% in 30-, 40- and 50-years group, respectively. Gender, cigarette, alchol, type of work, length of service and annual effective dose had no significant effect on lens opacity ( P>0.05) . Conclusion:Age is the main influencing factor of lens opacification in medical radiation workers, their radiation working time and intensity should be strictly controlled and radiation protection should be done.

Objective:To explore the association between long-term low-dose radiation exposure and other influencing factors with the risk of lens opacity on medical radiation workers.Methods:In July 2019, a retrospective cohort study was conducted by collecting the basic demographic information, dose data and health inspection result of 2708 radiologists in 22 hospitals of Guangzhou from the Occupational Health Inspection Information System and the Personal Dose Monitoring System of the Guangdong Prevention and Treatment Center for Occupational Disease between 2010 to 2018. The association between the average annual effective dose and lens opacity risk was calculated by using Time-Dependent Cox Regression Model.Results:From 2010 to 2018, the incidence density of lens opacity was 185.90/10000 person years. Compared with the radiation workers in the age <30 years group (93.74%) , the 5-year normal rate of lens in the age ≥50 years group (72.51%) was lower ( P<0.01) ; Compared with the radiation workers in the exposure age <10 years group (92.69%) , the 5-year normal rate of lens in more than 20 years exposed group (83.05%) was lower ( P<0.01) . Multifactor analysis showed that age was an independent influencing factor for lens opacity in medical radiation workers ( HR=14.485, P<0.01) . The risk of lens opacification increased by 4.9%, 10.1% and 15.5% in 30-, 40- and 50-years group, respectively. Gender, cigarette, alchol, type of work, length of service and annual effective dose had no significant effect on lens opacity ( P>0.05) . Conclusion:Age is the main influencing factor of lens opacification in medical radiation workers, their radiation working time and intensity should be strictly controlled and radiation protection should be done.