Objective To compare the effects of cleaning oral among different nursing methods for patients with dysphagia after brain injury who take food by gastric tube as well as by mouth. Methods A total of 59 patients with dysphagia after brain injury were divided into research group ( 29 cases, mouth nursing by modified method of brushing their teeth and irrigation ) and control group ( 30 cases, mouth nursing by traditional oral care routine) according to the random number table method from October 2012 to May 2014. Results were observed by comparing oral condition, indexes of pharyngeal swab culture and water-swallowing test. Results Incidence rates of halitosis and unclean mouth were all 13. 8% in the research group which were lower than those (73. 3%, 63. 3%) in the control group with statistically significant differences (χ2 =21. 208, 15. 214;P<0. 01). The effective rate of water-swallowing test was 79. 3% in the research group which was higher than that (56. 7%) in the control group (χ2 =12. 202,P<0. 01). There was no statistically significant difference in abnormity rates between two groups before intervention (P >0. 05). The abnormity rate in the research group was lower than that in the control group at 4th week (χ2 =8. 958,P <0. 01). There was statistically significant difference in abnormity rate before interventions and at 4th week in the research group (P<0.01), with no statistically significant difference in the control group (P>0.05). The rate of oral mucosa bleeding was 3. 4% in the research group and 6. 7% in the control with no statistically significant difference (χ2 =0. 316,P >0. 05), but there was no mechanical injury of oral mucosa in two groups. There was no statistically significant difference in index of water-swallowing test between two groups before interventions ( P>0. 05), with significant difference at 4th week (P<0. 01). Conclusions The implementation of mouth nursing by modified method of brushing their teeth and irrigation not only can achieve the purpose to clean oral effectively, but also can reduce oral bacteria and promote the recovery of swallowing function.