Objective To investigate the application value of the carbohydrate antigen 125(CA125)and ovarian cancer risk pre-diction model(ROM A)in risk assessment for endometrial endometriosis patient in Yangchun area.Methods A total of 433 cases of endometrial endometriosis patient in 3 hospitals were selected as the objects of the retrospective research.ELISA method was used to detect the CA125 and human epididymis protein 4(HE4)levels before operation.ROMA formula was used to calculate the RO-MA index cutoff value,correlation between CA125 level and ROMA index cutoff value and staging of endometriosis cysts and post-operative pregnancy rate was analyzed,and the CA125 level and ROMA index cutoff value in endometriosis risk assessment were discussed.Results The endometrial cyst stage Ⅰ,Ⅱ,Ⅲ,the serum CA125 level and the ROMA index truncation value of the preg-nant women were lower than those of the non pregnant women,and there is a statistically significant difference in comparison(P<0.05);the serum CA125 level and ROMA index cutoff value and staging of ovarian endometriosis cyst showed a positive correlation (r=0.986 2,0.988 3;P<0.05);the level of serum CA125 and the truncated value of ROMA index were negatively correlated with the pregnancy rate of patients with endometriosis(r=0.597 5,0.952 8;P<0.05);the accuracy,specificity,sensitivity,positive and negative prediction value and diagnostic coincidence rate of ROMA index in patients with endometriosis after operation were higher than those of CA125(P<0.05).Conclusion CA125 and ROMA index can be used for risk assessment of patients with endometrio-sis and assessment of postoperative pregnancy risk,but the evaluation value of ROM A index is better than that of CA 125.