BACKGROUNDTo compare the therapeutic effect, adverse reaction and effect on immunity of chemotherapy combined Aidi injection (AI) with those of chemotherapy alone in the treatment of advanced non small cell lung cancer (NSCLC).

METHODSNinety eight cases of advanced NSCLC were randomly divided into two groups, trial group and control group. In the trial group, NP plus AI (60 80 ml) were given intravenously by dissolving in 400 ml of normal saline per day for 8-10 days, while in the control group, only NP chemotherapy was given. Navelbine (25 mg/m², d1, 8) and cisplastin (40 mg/m², d1-3) were chosen in the chemotherapy. Each patient received at least two cycles of treatment.

RESULTSThe effective rate in the trial group and the control group was 53.1% and 44.9% respectively, without significant difference between the two groups ( P > 0.05). But the rate of progression, adverse reactions in bone marrow and digestive tract, and change of immunity in the trial group were all lower than those in the control group ( P < 0.05), and the improvement in Karnofsky score in the trial group was higher than that in the control group ( P < 0.05).

CONCLUSIONSChemotherapy of NP combined with AI shows benefit in the treatment of advanced NSCLC. AI could decrease the influence on immunity and adverse reaction of chemotherapy, and improve the quality of life in patients with NSCLC.

The flowers of Buddleja officinalis has a long history of being used as a medicine and is widely used in clinical practice，mainly for the treatment of swelling and pain of eye ，afraid of seeing strong light ，easy to shed tears ，pannus. Since its development，there are many aliases and variant names ，and the origins and place of origin are confused and complicated . Based on this，the author researches the name ，origin，place of origin ，processing，taste and meridian tropism ，efficacy，functions and indications of B. officinalis flower by consulting ancient and modern literature . The results show that the name of B. officinalis floweris first recorded in the book KaibaoBencao of the Song Dynasty ，including many variant names such as “mimenghua” “yang’erduo”“dongbudiao”，etc.；the origins of it shall be the dried flowers or buds of B. officinalis Maxim.，which belongs to the family of Loganiaeeae ，stated in the Chinese Pharmacopoeia （2020 edition）.In ancient times ，B. officinalis flower is mainly produced in Sichuan ，Chongqing，Yunnan，Guizhou and other places ；the processing methods mainly include cleansing ，stir-frying， wine-frying，honey-frying，honey wine -frying，licorice-frying and so on . Nowadays，B. officinalis flower is mainly produced in Shanxi，Shaanxi，Gansu，Sichuan and other places ；the processing methods mainly include cleansing and honey -frying. About its taste andmeridian tropism ，the ancient herbal understanding is more consistent ，i.e. taste sweet ，flat or slightly cold ，non-toxic， passing through liver meridian channel ；the flower of B. officinalis is good at wind -expelling and blood -cooling therapy ，clearing liver and improving vision ，eliminating eye screens ；it can be used to treat eye diseases caused by heat evil of liver meridian .

There are many kinds o f Taraxacum plants，which are widely distributed . The dried whole plants of many kinds of plants can be used as medicinal materials ，and the origin is confused . This study finds that Taraxaci Herba first appears as “Pugoncao”in the Liu Juanzi Guiyifang of Jin Dynasty after consulting ancient herbal books ，medical books ，prescription books and modern literature . According to characteristics ，morphology，color and sound of the plant ，it has “Huanghualang”， “Gounoucao”，“Fugongying”，“Pugongying”，“Huanghuadiding”and other aliases . Taraxaci Herba originates from the dried whole plant of Compositae family Taraxacum mongolicum Hand.-Mazz.，T. borealisinense Kitam. or several plants of the same genus . Similar to it ，Sonchus oleraceus Linn.（also known as “Kujucai”）cannot replace Taraxaci Herba as medicine . Because of its characteristics of rapid reproduction and vigorous growth ，Taraxaci Herba is widely distributed in most areas of China .“Absolutely no in Lingnan ”stated in Bencao Gangmu is inconsistent with the actual situation after consulting the relevant works . Ancient physicians take growth height of Taraxaci Herba as their quality standard . Now，those with many leaves ，gray green color and long roots are preferred . Ancient doctors pointed out that Taraxaci Herba were mostly harvested in April and May of the lunar calendar ， and modern research believes that it should be harvested in the near flowering period . In ancient times ，Taraxaci Herba is processed by many methods ，such as purification ，charcoal-frying，honey-frying and wine -frying. In modern times ，purification is the main method. This paper provides theoretical support for the value development and rational utilization of Taraxaci Herba by systematically researching its name ，origin，place of production ，harvesting and processing .