1.Textual research on the flowers of Buddleja officinalis
Congcong QIN ; Qinyuan DU ; Zhaoshuang ZHAN ; Jiafeng WANG
China Pharmacy 2022;33(19):2423-2427
The flowers of Buddleja officinalis has a long history of being used as a medicine and is widely used in clinical practice,mainly for the treatment of swelling and pain of eye ,afraid of seeing strong light ,easy to shed tears ,pannus. Since its development,there are many aliases and variant names ,and the origins and place of origin are confused and complicated . Based on this,the author researches the name ,origin,place of origin ,processing,taste and meridian tropism ,efficacy,functions and indications of B. officinalis flower by consulting ancient and modern literature . The results show that the name of B. officinalis floweris first recorded in the book KaibaoBencao of the Song Dynasty ,including many variant names such as “mimenghua” “yang’erduo”“dongbudiao”,etc.;the origins of it shall be the dried flowers or buds of B. officinalis Maxim.,which belongs to the family of Loganiaeeae ,stated in the Chinese Pharmacopoeia (2020 edition).In ancient times ,B. officinalis flower is mainly produced in Sichuan ,Chongqing,Yunnan,Guizhou and other places ;the processing methods mainly include cleansing ,stir-frying, wine-frying,honey-frying,honey wine -frying,licorice-frying and so on . Nowadays,B. officinalis flower is mainly produced in Shanxi,Shaanxi,Gansu,Sichuan and other places ;the processing methods mainly include cleansing and honey -frying. About its taste andmeridian tropism ,the ancient herbal understanding is more consistent ,i.e. taste sweet ,flat or slightly cold ,non-toxic, passing through liver meridian channel ;the flower of B. officinalis is good at wind -expelling and blood -cooling therapy ,clearing liver and improving vision ,eliminating eye screens ;it can be used to treat eye diseases caused by heat evil of liver meridian .
2.Herbal textural of Taraxaci Herba
Congcong QIN ; Qinyuan DU ; Yimin ZHANG ; Meiling SUN ; Zhaoshuang ZHAN ; Jiafeng WANG
China Pharmacy 2022;33(20):2556-2560
There are many kinds o f Taraxacum plants,which are widely distributed . The dried whole plants of many kinds of plants can be used as medicinal materials ,and the origin is confused . This study finds that Taraxaci Herba first appears as “Pugoncao”in the Liu Juanzi Guiyifang of Jin Dynasty after consulting ancient herbal books ,medical books ,prescription books and modern literature . According to characteristics ,morphology,color and sound of the plant ,it has “Huanghualang”, “Gounoucao”,“Fugongying”,“Pugongying”,“Huanghuadiding”and other aliases . Taraxaci Herba originates from the dried whole plant of Compositae family Taraxacum mongolicum Hand.-Mazz.,T. borealisinense Kitam. or several plants of the same genus . Similar to it ,Sonchus oleraceus Linn.(also known as “Kujucai”)cannot replace Taraxaci Herba as medicine . Because of its characteristics of rapid reproduction and vigorous growth ,Taraxaci Herba is widely distributed in most areas of China .“Absolutely no in Lingnan ”stated in Bencao Gangmu is inconsistent with the actual situation after consulting the relevant works . Ancient physicians take growth height of Taraxaci Herba as their quality standard . Now,those with many leaves ,gray green color and long roots are preferred . Ancient doctors pointed out that Taraxaci Herba were mostly harvested in April and May of the lunar calendar , and modern research believes that it should be harvested in the near flowering period . In ancient times ,Taraxaci Herba is processed by many methods ,such as purification ,charcoal-frying,honey-frying and wine -frying. In modern times ,purification is the main method. This paper provides theoretical support for the value development and rational utilization of Taraxaci Herba by systematically researching its name ,origin,place of production ,harvesting and processing .
3.TCM Intervention on Pyroptosis Based on Yin-Yang Theory: A Review
Qinyuan DU ; Congcong QIN ; Yimin ZHANG ; Meiling SUN ; Xijun MA ; Cheng LI ; Sichao ZHANG
Chinese Journal of Experimental Traditional Medical Formulae 2022;28(22):276-282
Cell pyroptosis is a programmed death of inflammatory cells. Many members of the gasdermin family (the effector protein family that forms pores) participate in the pathological process of a variety of diseases, such as cancer, myocardial ischemia, renal injury, and osteoarthritis, mainly by activating cysteine aspartate-specific protease (Caspase) for polymerization and shear. Cell pyroptosis has bidirectional regulation. Induction of pyroptosis can promote cell clearance under pathological conditions (such as cancer and tumor cells), but long-term induction of pyroptosis can lead to abnormal lipid and related vitamin metabolism in vivo. Regulating the balance between cell pyroptosis and proliferation is an important target for traditional Chinese medicine (TCM) treatment of diseases. The Yin-Yang theory runs through the whole process of TCM diagnosis and treatment, which is used to explain the physiological and pathological changes of human body and guide the theory, diagnosis and treatment of diseases and health care. The balance between cell proliferation and pyroptosis is essentially the embodiment of Yin-Yang balance at the cellular level, and the theory of Yin-Yang spontaneous harmonization dominates the balance. TCM intervention on cell pyroptosis is mainly reflected in promoting and inhibiting cell pyroptosis, which has the same significance as Yin-Yang regulation. Based on this theory, this paper revealed the relationship between TCM inhibiting and promoting cell pyroptosis through the Yin-Yang theory, to provide theoretical support for the modernization of the Yin-Yang theory and new goals for the diagnosis and treatment of diseases.