Objective:To investigate the risk factors of venous thrombosis associated with peripherally inserted central catheter (PICC) in lymphoma patients undergoing chemotherapy.Methods:Using the convenient sampling method, a total of 135 patients with lymphoma undergoing chemotherapy who were admitted to Department of Oncology in Xinxiang Central Hospital from September 2019 to September 2020 were selected as the research objects. According to the occurrence of PICC-related venous thrombosis, they were divided into the thrombosis group ( n=23) and the non-thrombotic group ( n=112) . The general data, PICC catheter vein, catheter tip position, PICC catheter limb and other data were collected. Binomial Logistic regression analysis was used to analyze the risk factors of PICC-related venous thrombosis. Results:The incidence of PICC-related venous thrombosis in lymphoma patients undergoing chemotherapy was 17.04% (23/135) . Binomial logistic regression analysis showed that the catheterized vein was the cephalic vein, the catheter tip was located within the upper 2/3 of the superior vena cava, and the ratio of catheter diameter divided by vein diameter greater than or equal to 67% were independent risk factors of PICC-related venous thrombosis in lymphoma chemotherapy patients ( P<0.01) . Conclusions:The risk factors of PICC-related venous thrombosis in lymphoma chemotherapy patients mainly include the cephalic vein, the catheter tip within the upper 2/3 of the superior vena cava and the ratio of catheter diameter to vein diameter greater than or equal to 67%.Nursing staff should focus on high-risk population and actively take interventions to reduce the incidence of PICC-related venous thrombosis.