Objective To study the diagnostic value of serum long chain non coding RNA(lncRNA)CB-SLR,α trypsin H4 heavy chain(ITIH4)in early gastric cancer in the elderly.Methods From 2020 to 2022,a total of 90 elderly patients with early gastric cancer diagnosed and treated in the hospital were selected as the early gastric cancer group,while 45 patients with chronic atrophic gastritis diagnosed and treated in the same period were selected as atrophic gastritis group and 45 healthy people undergoing physical examination in the same period were selected as the healthy control group.The serum levels of lncRNA CBSLR and ITIH4 in each group were detected by fluorescence quantitative PCR and enzyme linked immunosorbent assay.Pearson correlation analysis was performed to determine the correlation between serum lncRNA CBSLR and ITIH4 levels with tumor markers carcinoembryonic antigen(CEA)and carbohydrate antigen(CA)19-9.The levels of serum lncRNA CBSLR and ITIH4 among patients with different clinicopathological characteristics were com-pared.The diagnostic value of serum lncRNA CBSLR and ITIH4 in elderly patients with early gastric cancer was analyzed by receiver operating characteristic curve.Results The serum levels of lncRNA CBSLR,ITIH4,CEA and CA19-9 in the early gastric cancer group were significantly higher than those in the atrophic gastritis group and health control group(all P＜0.05).There was significant positive correlation between serum ln-cRNA CBSLR,ITIH4 and CEA,CA19-9 levels in patients with early gastric cancer(r=0.601-0.751,all P＜0.05).In patients with early gastric cancer,serum IncRNA CBSLR and ITIH4 were related to tumor diame-ter,depth of invasion,differentiation type,and lymph node metastasis(all P＜0.05),but not related to age,gender,tumor location,and gross type(all P＞0.05).The area under the curve of combined detection of ser-um lncRNA CBSLR,ITIH4,CEA and CA19-9(0.912,95％CI:0.858-0.949)for the diagnosis of early gas-tric cancer was higher than that of serum lncRNA CBSLR(0.833,95％CI:0.784-0.879),ITIH4(0.806,95％CI:0.760-0.847),CEA(0.791,95％CI:0.742-0.830),and CA19-9(0.766,95％CI:0.710-0.815)alone(Z=4.482,5.130,5.231,6.117,all P＜0.05).Conclusion The elevated levels of serum lncRNA CB-SLR and ITIH4 in elderly patients with early gastric cancer are associated with adverse clinicopathological characteristics of gastric cancer.The combination of serum lncRNA CBSLR,ITIH4,CEA and CA19-9 has high diagnostic value for elderly patients with early gastric cancer.

Alzheimer's disease （AD） is a common degenerative disease of the central nervous system in the elderly， with memory impairment and behavioral changes as the main clinical manifestations. Modern research has demonstrated that many herbs with both medicinal and edible values have anti-oxidation and anti-aging activities. In addition， these herbs are naturally safe and play a role in disease prevention and health care. The 110 medicinal and edible herbs announced by the National Health Commission of the People's Republic ofChina in 2021 were studied. The relevant papers published in the last five years were searched against CNKI， VIP， Wanfang Data， PubMed and other databases. The effects， mechanism， and active ingredients of the medicinal and edible herbs against Alzheimer's disease were summarized. The results showed that more than 30 herbs including Ginseng Radix et Rhizoma， Curcumae Longae Rhizoma， Astragali Radix， Corni Fructus， Gastrodiae Rhizoma， Angelicae Sinensis Radix， Cistanches Herba， Croci Stigma， Glycyrrhizae Radix et Rhizoma， Ganoderma and their active ingredients were effective in the prevention and treatment of Alzheimer's disease. Among them， ten herbs that met the requirements were screened out for analysis. The medicinal and edible herbs and their active ingredients can act on multiple targets and treat Alzheimer's disease via multiple signaling pathways such as nuclear factor-κB （NF-κB）， mitogen-activated protein kinase 5 （MEK5）/extracellular signal-regulated kinase 5 （ERK5）， cytochrome C （CytC） and cysteine aspartate-specific protease （Caspase）-3/（Caspase）-9， Wnt/β-catenin， and brain-derived neurotrophic factor （BDNF）/tyrosine kinase receptor B （TrkB）/phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt）， thus improving learning， cognitive ability， and memory ability. Most of the medicinal and edible herbs have the tropism to the heart， spleen， liver， and kidney meridians and tonifying effect.