Objective To explore the effect of psychological nursing intervention on postoperativemental status and quality of life. Methods The 74 cases of patients with breast cancer after radical operation from January 2012 to January 2015 in our hospital,all married patients,all patients were randomly divided into intervention group(37 cases)and con-trol group(37 cases),were collected. All clinical data of patients with complete and signed the informed consent,vol-untary acceptance of various scale survey. Exclude the presence of severe somatic diseases associated with distant metastasis of the tumor. Results The psychological intervention group SAS score and SDS score were significantly lower than those before intervention, and psychological intervention group SAS score and SDS score were significantly lower than those of the control group,with significant difference(P<0.05),psychological intervention group do prognostic score function field the score and overall health status were compared with that before the intervention significantly elevated scores and psychological intervention group of the function field of the score and overall health status were significantly higher than those in control group,with statistically significant difference(P<0.05),psychological interven-tion group the symptoms score and domain specific symptoms scores were significantly decreased than before interven-tion,and psychological intervention group symptoms score and specificity of the field symptom scores were significantly lower than those in control group,with significant difference(P<0.05). Conclusion The psychological nursing interven-tion in breast cancer patients is conducive to improve the psychological status of the patients after operation,improve the quality of life of patients.