1.Chemical Constituents of Fibraurea recisa Pierre
Haiyin WANG ; Linfen DING ; Xingde WU ; Shuangyan WANG ; Juan HE ; Qinshi ZHAO ; Liudong SONG
Journal of Kunming Medical University 2014;(1):1-4
Objective The purpose of this study was to investigate the chemical constituents of Pierre. Methods The chemical compositions were isolated by silica gel column chromatography, semi-preparative HPLC,Sephadex LH-20, and MPLC packed with MCI gel, and their structures were identified on the basis of chemical and spectroscopic evidence (NMR and MS) . Results Eight compounds were obtained and determined as fibraurin (1),makisterone A (2),cycloartenol (3),feruloylphenethylamine (4),trans- -feruloyltyramine(5),β-sitosterol(6),1-monopalmitin(7),1-sinapoyl-β-D-glucopyranoside(8). Conclusion Compounds 2-8 were isolated from this plant for the first time.
2.Progress in the role of sulforaphane in the treatment of malignant tumors
Qinshi WANG ; Yi YANG ; Tongbao FENG ; Ping ZHANG
Journal of Chinese Physician 2023;25(10):1584-1589
Sulforaphane (SFN) is an isothiocyanate rich in cruciferous vegetables, and is one of the plant active substances with strong anticancer activity. SFN can protect cells from environmental carcinogens and induce growth arrest and apoptosis of various cancer cells. This article reviews the research progress of SFN in tumor prevention, treatment, and its role in tumor stem cells, explores the feasibility of SFN in clinical application for cancer prevention, and provides new strategies to reduce the development and recurrence of malignant tumors and improve patient survival.