RIA of LH and FSH in 437 cases and PRLin 287 cases of secondary amenorrhea were performed. According to the results they can be divided into 5 groups: hypergonadotropic amenorrhea 132 cases (30.2%), hypogonadotropic amenorrhea 44 cases (10.1%), normogonadotropic amenorrhea 40 cases (9.1%), amenorrhra with increased LH/FSH ratio 94 cases (21.5%) and hyperprolactinemic amenorrhea 127 cases of which 117 cases (92.1%) had galactorrhea. The clinical features, laparoscopy findings and results of treatment were presented.

Objective To investigate the effects of long-term,low-dose hormone replacement therapy(HRT) on serum level of creactive protein(CRP) and homocysteine(Hcy) in postmenopausal women.Methods A total of 141 postmenopausal women were selected from medical staff of the Peking Union Medical College Hospital.Of these,63 subjects have been treated with low-dose sex hormone for over 5 years(HRT group),78 subjects have never received hormone replacement therapy as control group.The serum levels of CRP and Hcy in two groups were evaluated.Results The serum level of estradiol(E_2) in HRT group was significant higher than that in control group(median,inter-quartile range;33.8 ng/L,30.9 vs 21.3 ng/L,33.2)(P0.05).There was no correlation between the serum level of CRP,Hcy and the plasma levels of E_2 and FSH respectively.Conclusion Long-term and low-dose HRT does not increase the serum level of CRP and Hcy in postmenopausal women.

Objective． Bone mineral density（BMD） was measured in normal Chinese women with single X-ray absorptiometry （SXA） and dual energy X-ray absorptiometry （DEXA）． These two methods were compared to evaluate the sensitivity in reflecting bone loss．Methods． Measurements were performed in 300 women aged 20～79（5 for each age）． The 8mm distal，1／4 distal， ultra distal site of the nondominant forearm were measured with SXA； the AP spine（L2-4）， right femoral neck（Neck）， Ward's triangle（Ward）and trochantor （Troch） were measured with DEXA． Ten women had 5 repeated measurements to evaluate the reproducibility of the equipments．Results． The BMD peak for Neck and Ward was found between age 20～29， for ultra distal and L2-4 at age 30～39， for 8mm distal， 1／4 distal and Troch at age 40～49． After reaching the peak values， BMD at all sites decreased with increasing age． The highest rate of yearly loss of BMD was at 8mm distal． Results of measurement showed significant correlation between SXA and DEXA． Comparing with premenopausal women， the bone loss rate in postmenopausal women was faster and highest up to 11～15 years and the highest rate was at the Ward．Conclusion． The present study gives the normal values of BMD at seven sites for normal Chinese women． The ages of BMD peak were different at seven sites． The yearly loss of BMD was highest at 8mm distal， it seemed to be the sensitive region for bone loss with age． The postmenopausal women had highly significantly loss bone mass than the premenopausal women． Comparing with premenopause， postmenopause BMD for Ward's triangle with DEXA seemed to be most sensitive to the effect of menopause．

Abortifacient Agents, Steroidal ; administration & dosage ; Abortion, Induced ; methods ; Androgen Antagonists ; administration & dosage ; Contraceptives, Oral ; administration & dosage ; Female ; Fertilization in Vitro ; methods ; Gonadotropin-Releasing Hormone ; administration & dosage ; analogs & derivatives ; Hormone Replacement Therapy ; methods ; Hormones ; administration & dosage ; Humans ; Mifepristone ; administration & dosage ; Norpregnenes ; administration & dosage ; Pregnancy

Objective　To clarify the role of sexual related Y (SRY) gene detection in the diagnosis of gonadal dysgenesis. Methods　Sixteen cases of gonadal dysgenesis were included in this study: 5 with androgen insensitivity syndrome, 1 with 17-α-hydroxylase deficiency, 4 with true hermaphrodite, 2 with 45,X/46,XY gonadal dysgenesis, 1 with 45,X gonadal dysgenesis, 1 with XY pure gonadal dysgenesis, 1 with testicular regression, and 1 XY female who gave birth to a normal baby. SRY gene was detected by using polymerase chain reaction (PCR) in blood and gonad samples and by direct sequencing of the SRY motif. Results　Among the 16 cases, 15 were blood SRY positive, among which 13 (86.7%) showed the presence of testicular tissue, and 2 showed ovaries without testicular tissue. One SRY negative case showed the presence of testicular tissue. In 3 cases, SRY detection in gonadal tissue correlated with pathological findings but not with blood karyotype. The correlation between peripheral blood SRY and the pathology of the gonads was 81.25% and the correlation between the presence of peripheral blood Y chromosome and pathology of the gonads was 68.75%. Sequencing of the SRY motif in an XY female who gave birth to a normal baby showed no mutation. Conclusions　SRY detection is more sensitive and specific than blood karyotype in the prediction of the presence of testicular tissue. Peripheral blood karyotype does not necessarily reflect gonadal type. There may be testicular related factors other than the SRY gene.